Herein, we report a general and practical electrochemical method for the synthesis of alpha-keto esters from malonic acid derivatives via alpha-carbonyl carbocations. Although these cations are typically unstable, they can be efficiently generated under Hofer-Moest-type conditions when stabilized by an alpha-acetoxy substituent. This metal- and supporting-electrolyte-free approach grants straightforward access to alpha-keto esters that are otherwise challenging to obtain using conventional methods.
e-Carbonyl: Electrochemical Synthesis of α-Keto Esters via α-Carbonyl Carbocations
Campinoti C.;Lessi M.;Del Vecchio A.;Lam K.
2026-01-01
Abstract
Herein, we report a general and practical electrochemical method for the synthesis of alpha-keto esters from malonic acid derivatives via alpha-carbonyl carbocations. Although these cations are typically unstable, they can be efficiently generated under Hofer-Moest-type conditions when stabilized by an alpha-acetoxy substituent. This metal- and supporting-electrolyte-free approach grants straightforward access to alpha-keto esters that are otherwise challenging to obtain using conventional methods.File in questo prodotto:
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