Leptin and its receptor (ObR) expression were investigated by immunohistochemistry in normal, hyperplastic and neoplastic canine mammary tissues and related to clinical-pathological features. Leptin expression was detected in healthy mammary tissues, adenosis and in benign mammary tumours and was lower in ductal hyperplasias and malignant tumours. A high percentage of ObR-positive cells were present in adenosis, benign tumours and in complex carcinomas, while ObR expression was lower in healthy mammary tissues, in ductal hyperplasias and in a large part of invasive mammary carcinomas. Our data demonstrated that cancer cells expressed at low level leptin and ObR in canine mammary tumours with a more aggressive behaviour, as well as in lymph node metastases. Consequently, leptin and ObR expressions in this species resulted to be not associated with a reduced overall survival.
|Autori:||Ressel L; Finotello R; Innocenti V M; Vannozzi I; Poli A|
|Titolo:||Preliminary report on the expression of leptin and leptin receptor (Obr) in normal, hyperplastic and neoplastic canine mammary tissues|
|Anno del prodotto:||2012|
|Digital Object Identifier (DOI):||10.1016/j.rvsc.2011.07.020|
|Appare nelle tipologie:||1.1 Articolo in rivista|