endo-3-Amino-exo-2-(3,4-dihydroxyphenyl)-2-hydroxybicyclo[2.2.l]hep(~4ea ) and its N-isopropyl derivative (4b) were synthesized and assayed for their adrenergic activity on various isolated preparations. Compounds 4a and 4b, tested up to a dose of la-4 M, did not reveal any activity, either stimulant or blocking, on the a- and 8-adrenoceptors. Possible rationalizations of the results obtained, however, are suggested.
SYNTHESIS AND EVALUATION OF THE PHARMACOLOGICAL ACTIVITY OF RIGID ANALOGS OF SYMPATHOMIMETIC CATECHOLAMINES DERIVED FROM BICYCLO[2.2.1]HEPTANE
BALSAMO, ALDO;BRESCHI, MARIA CRISTINA;LAPUCCI, ANNALINA;MACCHIA, BRUNO;NENCETTI, SUSANNA;NIERI, PAOLA;ORLANDINI, ELISABETTA
1989-01-01
Abstract
endo-3-Amino-exo-2-(3,4-dihydroxyphenyl)-2-hydroxybicyclo[2.2.l]hep(~4ea ) and its N-isopropyl derivative (4b) were synthesized and assayed for their adrenergic activity on various isolated preparations. Compounds 4a and 4b, tested up to a dose of la-4 M, did not reveal any activity, either stimulant or blocking, on the a- and 8-adrenoceptors. Possible rationalizations of the results obtained, however, are suggested.File in questo prodotto:
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