Some 7-aminocephalosporanic acid (7-ACA) derivatives substituted on the C(7) nitrogen with 2-(arylmethyloxyimino)propionyl (3a-f), 2-(arylmethyloxyamino)propionyl (4a-d) and (arylmethyloxyamino)acetyl (2a-d) moieties were synthesized by reaction of the appropriate acylating agents with 7-ACA protected as a t-butyl ester, followed by removal of the t-butyl protecting group. The new compounds; tested in vitro for their antimicrobial activity against Gram-positive and Gram-negative bacteria, proved to possess a modest activity directed only against Gram-positive microorganisms. (C) 1999 Elsevier Science S.A. All rights reserved.
Synthesis And Antimicrobial Property Of Cephalosporin Derivatives Substituted On The C(7) Nitrogen With Arylmethyloxyimino Or Arylmethyloxyamino Alkanoyl Groups
MACCHIA, MARCO;NENCETTI, SUSANNA;ORLANDINI, ELISABETTA;ROSSELLO, ARMANDO;
1999-01-01
Abstract
Some 7-aminocephalosporanic acid (7-ACA) derivatives substituted on the C(7) nitrogen with 2-(arylmethyloxyimino)propionyl (3a-f), 2-(arylmethyloxyamino)propionyl (4a-d) and (arylmethyloxyamino)acetyl (2a-d) moieties were synthesized by reaction of the appropriate acylating agents with 7-ACA protected as a t-butyl ester, followed by removal of the t-butyl protecting group. The new compounds; tested in vitro for their antimicrobial activity against Gram-positive and Gram-negative bacteria, proved to possess a modest activity directed only against Gram-positive microorganisms. (C) 1999 Elsevier Science S.A. All rights reserved.File in questo prodotto:
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