Some 7-aminocephalosporanic acid (7-ACA) derivatives substituted on the C(7) nitrogen with 2-(arylmethyloxyimino)propionyl (3a-f), 2-(arylmethyloxyamino)propionyl (4a-d) and (arylmethyloxyamino)acetyl (2a-d) moieties were synthesized by reaction of the appropriate acylating agents with 7-ACA protected as a t-butyl ester, followed by removal of the t-butyl protecting group. The new compounds; tested in vitro for their antimicrobial activity against Gram-positive and Gram-negative bacteria, proved to possess a modest activity directed only against Gram-positive microorganisms. (C) 1999 Elsevier Science S.A. All rights reserved.
|Autori:||Gentili D.; M. MACCHIA; E. MENCHINI; S. NENCETTI; E. ORLANDINI; ROSSELLO A; G. BROCCALI; D. LIMONTA|
|Titolo:||Synthesis And Antimicrobial Property Of Cephalosporin Derivatives Substituted On The C(7) Nitrogen With Arylmethyloxyimino Or Arylmethyloxyamino Alkanoyl Groups|
|Anno del prodotto:||1999|
|Digital Object Identifier (DOI):||10.1016/S0014-827X(99)00017-8|
|Appare nelle tipologie:||1.1 Articolo in rivista|