N-Phosphorylimines undergo Lewis acid-catalyzed Diels-Alder reactions with Danishefsky's diene. Application of the chiral catalyst zinc (II)- (S)-BINOL results in good-to-low asymmetric induction but poor chemical conversion. However, the absolute stereochemistry of novel aza-Diels-Alder cycloadducts, such as diethyl 4-oxo-2-phenyl-3,4-dihydropyridin-1(2H)-ylphosphonate, can be determined using circular dichroism (CD). Comparison between experimental and TDDFT-calculated CD spectrum shows that use of the (S)-catalyst results in predominant formation of the (6R) cycloadducts.
|Autori:||REGINATO G.; DI BARI L; SALVADORI P.; GUILARD R.|
|Titolo:||Chiral atropisomeric metalloporphyrins in the enantioselective styrene epoxidation|
|Anno del prodotto:||2000|
|Appare nelle tipologie:||1.1 Articolo in rivista|