A series of new 1,8-naphthyridine and quinoline derivatives were synthesized and evaluated for their cannabinoid receptor affinity. In particular, compounds 2, 5, 11, and 13 showed a high CB2 affinity and CB2 versus CB1 selectivity, in agreement with molecular modeling studies. Furthermore, compound 2 also exhibited in vivo antinociceptive effects. (c) 2007 Elsevier Ltd. All rights reserved.
|Autori:||MANERA C; CASCIO M G; BENETTI V; ALLARÀ M; TUCCINARDI T; MARTINELLI A; SACCOMANNI G; VIVOLI E; GHELARDINI C; DI MARZO V; FERRARINI P L|
|Titolo:||New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists|
|Anno del prodotto:||2007|
|Digital Object Identifier (DOI):||10.1016/j.bmcl.2007.09.089|
|Appare nelle tipologie:||1.1 Articolo in rivista|