A series of new 1,8-naphthyridine and quinoline derivatives were synthesized and evaluated for their cannabinoid receptor affinity. In particular, compounds 2, 5, 11, and 13 showed a high CB2 affinity and CB2 versus CB1 selectivity, in agreement with molecular modeling studies. Furthermore, compound 2 also exhibited in vivo antinociceptive effects. (c) 2007 Elsevier Ltd. All rights reserved.

New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists

MANERA, CLEMENTINA;TUCCINARDI, TIZIANO;MARTINELLI, ADRIANO;SACCOMANNI, GIUSEPPE;
2007

Abstract

A series of new 1,8-naphthyridine and quinoline derivatives were synthesized and evaluated for their cannabinoid receptor affinity. In particular, compounds 2, 5, 11, and 13 showed a high CB2 affinity and CB2 versus CB1 selectivity, in agreement with molecular modeling studies. Furthermore, compound 2 also exhibited in vivo antinociceptive effects. (c) 2007 Elsevier Ltd. All rights reserved.
Manera, Clementina; CASCIO M., G; Benetti, V; Allarà, M; Tuccinardi, Tiziano; Martinelli, Adriano; Saccomanni, Giuseppe; Vivoli, E; Ghelardini, C; DI MARZO, V; Ferrarini, P. L.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/199124
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