Protein kinases are key regulators of cell function that constitute one of the largest and most functionally diverse gene families, and knowledge of their three-dimensional structure could be of great help in the rational design of specific ligands. However, only about one quarter of human protein kinase structures has been experimentally defined; thus, kinase homology modeling techniques have been widely diffused. In this review, the most recent kinase homology models are reported, together with the most recent approaches and the main validation methods.
|Autori interni:||TUCCINARDI, TIZIANO|
|Autori:||TUCCINARDI T; MARTINELLI A|
|Titolo:||Protein Kinase Homology Models: Recent Developments and Results|
|Anno del prodotto:||2011|
|Digital Object Identifier (DOI):||10.2174/092986711796150441|
|Appare nelle tipologie:||1.1 Articolo in rivista|