CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishOn the basis of results previously obtained from structural and theoretical studies on @-adrenergicd rugs, a series of aliphatic oxime ether derivatives (AOEDs) was synthesized. As expected, pharmacological in vitro tests showed that compounds examined exhibit a marked and competitive antagonism at P-adrenoceptors; the P2/PI selectivity ratio indicated that they are more active on the tracheal than on the cardiac @-receptor. The chemical reactivity of the AOEDs was studied through the calculation of the electrostatic molecular potential (EMP) on a model compound in its preferred conformation. The results showed that the EMP trend agrees with that previously calculated for other @-blockingd rugs.
| Autori interni: | |
| Autori: | MACCHIA B; BALSAMO A; LAPUCCI A; MARTINELLI A; MACCHIA F; BRESCHI M. C; FANTONI B; MARTINOTTI E |
| Titolo: | An interdisciplinary approach to the design of new structures active at the beta-adrenergic receptor. Aliphatic oxime ether derivatives |
| Anno del prodotto: | 1985 |
| Digital Object Identifier (DOI): | 10.1021/jm00380a001 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
Copyright © 2021