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EnglishIn order to identify potential bioisosteric replacements for the diphosphate moiety, which is present in activated forms generated from antiherpes virus agents during their inhibitory action against herpes viruses, 5'-phosphonoacetamido (4) and 5'-O-sulfamoylcarbamoyl (5) derivatives of idoxuridine were synthesised as analogues of idoxuridine 5'-diphosphate (6). In this paper we report on the antiherpetic activity of 4 and 5. Moreover, a theoretical study is presented in which both the conformational and the electronic characteristics of 4 and 5 are compared with those of the diphosphate metabolite of idoxuridine (6), in order to verify the possibility of bioisosterism relationship between the phosphonoacetamido, the sulfamoylcarbamoyl and the diphosphate group.
| Autori interni: | |
| Autori: | MACCHIA M; MARTINELLI A; PARKIN A; ROSSELLO A |
| Titolo: | BIOISOSTERS OF THE DIPHOSPHATE GROUP IN ACTIVATED FORMS OF ANTIHERPES VIRUS AGENTS - A THEORETICAL-STUDY |
| Anno del prodotto: | 1994 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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