In order to identify potential bioisosteric replacements for the diphosphate moiety, which is present in activated forms generated from antiherpes virus agents during their inhibitory action against herpes viruses, 5'-phosphonoacetamido (4) and 5'-O-sulfamoylcarbamoyl (5) derivatives of idoxuridine were synthesised as analogues of idoxuridine 5'-diphosphate (6). In this paper we report on the antiherpetic activity of 4 and 5. Moreover, a theoretical study is presented in which both the conformational and the electronic characteristics of 4 and 5 are compared with those of the diphosphate metabolite of idoxuridine (6), in order to verify the possibility of bioisosterism relationship between the phosphonoacetamido, the sulfamoylcarbamoyl and the diphosphate group.
|Autori:||MACCHIA M; MARTINELLI A; PARKIN A; ROSSELLO A|
|Titolo:||BIOISOSTERS OF THE DIPHOSPHATE GROUP IN ACTIVATED FORMS OF ANTIHERPES VIRUS AGENTS - A THEORETICAL-STUDY|
|Anno del prodotto:||1994|
|Appare nelle tipologie:||1.1 Articolo in rivista|