Some N-(aroyl)-N-(phenylethyloxy)glycines (C) and N-(aroyl)-N-(arylmethyloxy)beta-alanines (D) were synthesised and tested as aldose reductase inhibitors (ARIs). Compounds C and D differ from the previously reported ARIs of type A in the presence of a further CH2 spacer between the aryl moiety and the oxyamidic oxygen and between the oxyamidic nitrogen and the carboxyl group. Compounds C revealed a certain loss of inhibitory activity with respect to the corresponding type A derivatives. Compounds D were found to be devoid of any appreciable inhibitory activity.

Synthesis and aldose reductase inhibitory activity of some N-(aroyl)-N-(arylalkyloxy)-glycines and -beta-alanines

MACCHIA, MARCO;NENCETTI, SUSANNA;ORLANDINI, ELISABETTA;ROSSELLO, ARMANDO
1996

Abstract

Some N-(aroyl)-N-(phenylethyloxy)glycines (C) and N-(aroyl)-N-(arylmethyloxy)beta-alanines (D) were synthesised and tested as aldose reductase inhibitors (ARIs). Compounds C and D differ from the previously reported ARIs of type A in the presence of a further CH2 spacer between the aryl moiety and the oxyamidic oxygen and between the oxyamidic nitrogen and the carboxyl group. Compounds C revealed a certain loss of inhibitory activity with respect to the corresponding type A derivatives. Compounds D were found to be devoid of any appreciable inhibitory activity.
Macchia, Marco; Menchini, E; Nencetti, Susanna; Orlandini, Elisabetta; Rossello, Armando
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/201686
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 8
social impact