The tetrahydronaphthalene analogs 4 and 5 of DCI (3b) and of its N-unsubstituted derivative (3a) were synthesized and tested for their beta-adrenergic properties by means of both binding tests and functional tests. Compounds 4 and 5 proved to possess a good affinity for beta-adrenergic receptors accompanied by an appreciable beta-blocking activity, thus indicating that the formal insertion of a beta-blocking drug such as DCI into a tetrahydronaphthalene structure is able to provide compounds which still possess a beta-blocking activity.

Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol

BRESCHI, MARIA CRISTINA;GIANNACCINI, GINO;LAPUCCI, ANNALINA;LUCACCHINI, ANTONIO;MANERA, CLEMENTINA;MARTINI, CLAUDIA;NENCETTI, SUSANNA;ROSSELLO, ARMANDO;
1993

Abstract

The tetrahydronaphthalene analogs 4 and 5 of DCI (3b) and of its N-unsubstituted derivative (3a) were synthesized and tested for their beta-adrenergic properties by means of both binding tests and functional tests. Compounds 4 and 5 proved to possess a good affinity for beta-adrenergic receptors accompanied by an appreciable beta-blocking activity, thus indicating that the formal insertion of a beta-blocking drug such as DCI into a tetrahydronaphthalene structure is able to provide compounds which still possess a beta-blocking activity.
Balsamo, A; Breschi, MARIA CRISTINA; Giannaccini, Gino; Lapucci, Annalina; Lucacchini, Antonio; Macchia, B; Manera, Clementina; Martini, Claudia; Martinotti, E; Nencetti, Susanna; Rossello, Armando; Scatizzi, R.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/206409
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