The tetrahydronaphthalene analogs 4 and 5 of DCI (3b) and of its N-unsubstituted derivative (3a) were synthesized and tested for their beta-adrenergic properties by means of both binding tests and functional tests. Compounds 4 and 5 proved to possess a good affinity for beta-adrenergic receptors accompanied by an appreciable beta-blocking activity, thus indicating that the formal insertion of a beta-blocking drug such as DCI into a tetrahydronaphthalene structure is able to provide compounds which still possess a beta-blocking activity.
Autori interni: | |
Autori: | BALSAMO A; BRESCHI M. C; GIANNACCINI G; LAPUCCI A; LUCACCHINI A; MACCHIA B; MANERA C; MARTINI C; MARTINOTTI E; NENCETTI S; ROSSELLO A; SCATIZZI R. |
Titolo: | Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol |
Anno del prodotto: | 1993 |
Digital Object Identifier (DOI): | 10.1016/0223-5234(93)90034-C |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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