The tetrahydronaphthalene analogs 4 and 5 of DCI (3b) and of its N-unsubstituted derivative (3a) were synthesized and tested for their beta-adrenergic properties by means of both binding tests and functional tests. Compounds 4 and 5 proved to possess a good affinity for beta-adrenergic receptors accompanied by an appreciable beta-blocking activity, thus indicating that the formal insertion of a beta-blocking drug such as DCI into a tetrahydronaphthalene structure is able to provide compounds which still possess a beta-blocking activity.
|Autori:||BALSAMO A; BRESCHI M. C; GIANNACCINI G; LAPUCCI A; LUCACCHINI A; MACCHIA B; MANERA C; MARTINI C; MARTINOTTI E; NENCETTI S; ROSSELLO A; SCATIZZI R.|
|Titolo:||Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol|
|Anno del prodotto:||1993|
|Digital Object Identifier (DOI):||10.1016/0223-5234(93)90034-C|
|Appare nelle tipologie:||1.1 Articolo in rivista|