Obesity is linked to increased thrombotic risk. Circulating leptin concentration correlates with body mass index. Microparticles are small (.05-1μm) vesicles shed by activated and apoptotic cells, involved in numerous pathophysiologically relevant phenomena including blood coagulation and thrombosis. We tested the hypothesis that leptin induces the shedding of procoagulant, tissue factor bearing microparticles by human peripheral blood mononuclear cells, and investigated the intracellular mechanisms leading to microparticle release upon incubation with leptin.

Leptin induces the generation of procoagulant, tissue factor bearing microparticles by human peripheral blood mononuclear cells

PETRINI, SILVIA;NERI, TOMMASO;CORDAZZO, CINZIA;BALIA, CRISTINA;SCALISE, VALENTINA;PAGGIARO, PIER LUIGI;PEDRINELLI, ROBERTO;CELI, ALESSANDRO
2016

Abstract

Obesity is linked to increased thrombotic risk. Circulating leptin concentration correlates with body mass index. Microparticles are small (.05-1μm) vesicles shed by activated and apoptotic cells, involved in numerous pathophysiologically relevant phenomena including blood coagulation and thrombosis. We tested the hypothesis that leptin induces the shedding of procoagulant, tissue factor bearing microparticles by human peripheral blood mononuclear cells, and investigated the intracellular mechanisms leading to microparticle release upon incubation with leptin.
Petrini, Silvia; Neri, Tommaso; Lombardi, Stefania; Cordazzo, Cinzia; Balia, Cristina; Scalise, Valentina; Paggiaro, PIER LUIGI; Pedrinelli, Roberto; Celi, Alessandro
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/789318
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