Acute Kidney Injury (AKI) is a severe disease associated with a sudden onset of renal parenchymal injury most typically characterized by generalized failure. AKI may to be severe and culminated with the requirement for renal replacement therapy (RRT) or death. The aim of this study was to evaluate potential prognostic factors (clinical and laboratory parameters), intra/inter dialysis complications and mortality rate in a cohort of dogs with AKI and AKI/CKD managed by hemodialysis (HD) at Department of Veterinary Science of University of Pisa between 2012 and 2015. We included 64 dogs with anamnestic, clinical, imaging and laboratory findings of AKI or acute on chronic kidney disease (AKI/CKD) managed by hemodialysis. All Dogs were also divided into two groups: survivors and non-survivors. Survivors were defined as patients remaining not dependent by dialysis for at least 30 days after discharge from the hospital. Data were statistically analyzed with GraphPad Prism® for Mac. In our cohort 43/64 were males and 21/64 were females. Mean age and body weight were 5.5 ± SD 3.3 years and 26.7 kg±1SD 1.6 kg respectively. At presentation 26/64 dogs were anuric (<0.5 ml/kg/h), 15/64 were oliguric (<1ml/kg/h) and 23/64 were non oliguric (>1ml/kg/h). 29/64 dogs were in AKI stage 5 (SrCr>10mg/dl), 29/64 were in AKI 4 (SrCr 5-10 mg/dL), 2/64 were in AKI 3 (SrCr 2.6-5mg/dL), 1/64 were in AKI 2 (SrCr 1.6-2.5) and 3/64 were in AKI 1 (SrCr<1.6mg/dL). Most of etiology of AKI in this dogs were: Leptospira infection (14/64), Leishmania infection (5/64), toxicity (8/64), ethylene glycol (3/64), pancreatitis (4/64), heart stroke (2/64), snake bite (2/64), uretheral obstruction (2/64), pyometra (3/64), unknown (17/64) and other causes (4/64). Non-survivors dogs were 37/6, while survivors were 27/64. T-Test unpaired showed significant difference at presentation in serum creatinine (p=0.047), phosphorus (p=0.0468), and ionic calcium (p=0.042) between survivors and non-survivors. No significant difference was found in serum urea, albumin, C-reactive protein (CRP) and potassium between survivors and non-survivors. In our cohort the overall survival rate was 42.2% and it showed similar to previously data reported. Serum creatinine, phosphorous and ionized calcium seemed to have a significant prognostic relevance, while serum urea, CRP and potassium did not seem to affect prognosis significantly.

RETROSPECTIVE OBSERVATION OF 64 DOGS WITH RENAL FAILURE MANAGED BY HEMODIALYSIS

PERONDI, FRANCESCA;LIPPI, ILARIA;CECCHERINI, GIANILA;MARCHETTI, VERONICA;GUIDI, GRAZIA
2016-01-01

Abstract

Acute Kidney Injury (AKI) is a severe disease associated with a sudden onset of renal parenchymal injury most typically characterized by generalized failure. AKI may to be severe and culminated with the requirement for renal replacement therapy (RRT) or death. The aim of this study was to evaluate potential prognostic factors (clinical and laboratory parameters), intra/inter dialysis complications and mortality rate in a cohort of dogs with AKI and AKI/CKD managed by hemodialysis (HD) at Department of Veterinary Science of University of Pisa between 2012 and 2015. We included 64 dogs with anamnestic, clinical, imaging and laboratory findings of AKI or acute on chronic kidney disease (AKI/CKD) managed by hemodialysis. All Dogs were also divided into two groups: survivors and non-survivors. Survivors were defined as patients remaining not dependent by dialysis for at least 30 days after discharge from the hospital. Data were statistically analyzed with GraphPad Prism® for Mac. In our cohort 43/64 were males and 21/64 were females. Mean age and body weight were 5.5 ± SD 3.3 years and 26.7 kg±1SD 1.6 kg respectively. At presentation 26/64 dogs were anuric (<0.5 ml/kg/h), 15/64 were oliguric (<1ml/kg/h) and 23/64 were non oliguric (>1ml/kg/h). 29/64 dogs were in AKI stage 5 (SrCr>10mg/dl), 29/64 were in AKI 4 (SrCr 5-10 mg/dL), 2/64 were in AKI 3 (SrCr 2.6-5mg/dL), 1/64 were in AKI 2 (SrCr 1.6-2.5) and 3/64 were in AKI 1 (SrCr<1.6mg/dL). Most of etiology of AKI in this dogs were: Leptospira infection (14/64), Leishmania infection (5/64), toxicity (8/64), ethylene glycol (3/64), pancreatitis (4/64), heart stroke (2/64), snake bite (2/64), uretheral obstruction (2/64), pyometra (3/64), unknown (17/64) and other causes (4/64). Non-survivors dogs were 37/6, while survivors were 27/64. T-Test unpaired showed significant difference at presentation in serum creatinine (p=0.047), phosphorus (p=0.0468), and ionic calcium (p=0.042) between survivors and non-survivors. No significant difference was found in serum urea, albumin, C-reactive protein (CRP) and potassium between survivors and non-survivors. In our cohort the overall survival rate was 42.2% and it showed similar to previously data reported. Serum creatinine, phosphorous and ionized calcium seemed to have a significant prognostic relevance, while serum urea, CRP and potassium did not seem to affect prognosis significantly.
2016
978-88-909092-8-3
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/804799
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