Objective: The effects of a collagen dressing on hard-to-heal venous leg ulcers (VLUs) were evaluated in this prospective, randomised, controlled study. Method: Patients with hard-to-heal VLU were included and divided into two groups using the block randomisation method. The first group was treated with a collagen and an alginate dressing (group A), and the second group with an alginate dressing alone (group B). Both groups also had a short-stretch compression system applied at every dressing change. The dressings were changed twice a week for 12 weeks or until the ulcer was healed. Granulation tissue improvement, wound size, overall dressing performance and dressing comfort were evaluated and recorded. Results: A total of 40 patients completed the study evaluation period. Group A had a 65% increase in granulation tissue compared to 38% in group B. The mean ulcer area was reduced to 45% in group A compared to 20% in group B at 12 weeks. No significant side effects were detected in either group. Patients of both groups were satisfied with their treatment and healing progress. Conclusion: The results of this study showed the effectiveness and safety of a collagen dressing in hard-to-heal VLUs as an adjunctive therapy with compression bandaging. These encouraging results may positively affect the quality of life of patients with chronic wounds. Declaration of interest: The research was funded with an unrestricted grant from MedSkin Solutions.

The use of a collagen matrix in hard-to-heal venous leg ulcers

ROMANELLI, MARCO;DINI, VALENTINA
2015

Abstract

Objective: The effects of a collagen dressing on hard-to-heal venous leg ulcers (VLUs) were evaluated in this prospective, randomised, controlled study. Method: Patients with hard-to-heal VLU were included and divided into two groups using the block randomisation method. The first group was treated with a collagen and an alginate dressing (group A), and the second group with an alginate dressing alone (group B). Both groups also had a short-stretch compression system applied at every dressing change. The dressings were changed twice a week for 12 weeks or until the ulcer was healed. Granulation tissue improvement, wound size, overall dressing performance and dressing comfort were evaluated and recorded. Results: A total of 40 patients completed the study evaluation period. Group A had a 65% increase in granulation tissue compared to 38% in group B. The mean ulcer area was reduced to 45% in group A compared to 20% in group B at 12 weeks. No significant side effects were detected in either group. Patients of both groups were satisfied with their treatment and healing progress. Conclusion: The results of this study showed the effectiveness and safety of a collagen dressing in hard-to-heal VLUs as an adjunctive therapy with compression bandaging. These encouraging results may positively affect the quality of life of patients with chronic wounds. Declaration of interest: The research was funded with an unrestricted grant from MedSkin Solutions.
Romanelli, Marco; Mulder, G.; Paggi, B.; Macchia, M.; Panduri, Salvatore; Dini, Valentina
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/818876
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