Zinc alkylcyanocuprates (Knochel reagents) are found to be active in the cross-coupling reaction with allenic bromides affording acetylenic products with a high regio and stereoselective 1,3-anti substitution. The coupling process, which has been successfully extended to functionalized cuprates, can also be performed with alkylzinc chlorides in the presence of catalytic amounts of cuprous salts.

Coupling of chiral 1-bromo-1,2-dienes with zinc-based cuprates: A new procedure for the regio and stereoselective synthesis of functionalized acetylenic compounds

CAPORUSSO, ANNA MARIA;FILIPPI, SARA;BARONTINI, FEDERICA;SALVADORI, PIERO
2000-01-01

Abstract

Zinc alkylcyanocuprates (Knochel reagents) are found to be active in the cross-coupling reaction with allenic bromides affording acetylenic products with a high regio and stereoselective 1,3-anti substitution. The coupling process, which has been successfully extended to functionalized cuprates, can also be performed with alkylzinc chlorides in the presence of catalytic amounts of cuprous salts.
Caporusso, ANNA MARIA; Filippi, Sara; Barontini, Federica; Salvadori, Piero
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/822104
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