Point-of-care applications and patients’ real-time monitoring outside a clinical setting would require disposable and durable sensors to provide better therapies and quality of life for patients. This paper describes the fabrication and performances of a temperature and a pH sensor on a biocompatible and wearable board for healthcare applications. The temperature sensor was based on a reduced graphene oxide (rGO) layer that changed its electrical resistivity with the temperature. When tested in a human serum sample between 25 and 43 °C, the sensor had a sensitivity of 110±10 Ω/°C and an error of 0.4±0.1 °C compared with the reference value set in a thermostatic bath. The pH sensor, based on a graphene oxide (GO) sensitive layer, had a sensitivity of 40±4 mV/pH in the pH range between 4 and 10. Five sensor prototypes were tested in a human serum sample over one week and the maximum deviation of the average response from reference values obtained by a glass electrode was 0.2 pH units. For biological applications, the temperature and pH sensors were successfully tested for in vitro cytotoxicity with human fibroblast cells (MRC-5) over 24 h.

Temperature and pH sensors based on graphenic materials

SALVO, PIETRO;CALISI, NICOLA;MELAI, BERNARDO;PAOLETTI, CLARA;LOMONACO, TOMMASO;PAOLICCHI, ALDO;SCATAGLINI, ILENIA;DINI, VALENTINA;ROMANELLI, MARCO;FUOCO, ROGER;DI FRANCESCO, FABIO
2017-01-01

Abstract

Point-of-care applications and patients’ real-time monitoring outside a clinical setting would require disposable and durable sensors to provide better therapies and quality of life for patients. This paper describes the fabrication and performances of a temperature and a pH sensor on a biocompatible and wearable board for healthcare applications. The temperature sensor was based on a reduced graphene oxide (rGO) layer that changed its electrical resistivity with the temperature. When tested in a human serum sample between 25 and 43 °C, the sensor had a sensitivity of 110±10 Ω/°C and an error of 0.4±0.1 °C compared with the reference value set in a thermostatic bath. The pH sensor, based on a graphene oxide (GO) sensitive layer, had a sensitivity of 40±4 mV/pH in the pH range between 4 and 10. Five sensor prototypes were tested in a human serum sample over one week and the maximum deviation of the average response from reference values obtained by a glass electrode was 0.2 pH units. For biological applications, the temperature and pH sensors were successfully tested for in vitro cytotoxicity with human fibroblast cells (MRC-5) over 24 h.
Salvo, Pietro; Calisi, Nicola; Melai, Bernardo; Cortigiani, B.; Mannini, M.; Caneschi, A.; Lorenzetti, G.; Paoletti, Clara; Lomonaco, Tommaso; Paolicchi, Aldo; Scataglini, Ilenia; Dini, Valentina; Romanelli, Marco; Fuoco, Roger; DI FRANCESCO, Fabio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/846469
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