MARZO, TIZIANO
 Distribuzione geografica
Continente #
NA - Nord America 7.211
AS - Asia 4.214
EU - Europa 2.528
SA - Sud America 816
Continente sconosciuto - Info sul continente non disponibili 525
AF - Africa 153
OC - Oceania 10
AN - Antartide 1
Totale 15.458
Nazione #
US - Stati Uniti d'America 7.017
SG - Singapore 1.313
CN - Cina 1.076
IT - Italia 977
BR - Brasile 670
HK - Hong Kong 658
VN - Vietnam 468
SE - Svezia 291
DE - Germania 195
FI - Finlandia 192
BG - Bulgaria 174
FR - Francia 169
RU - Federazione Russa 122
JP - Giappone 118
KR - Corea 118
CA - Canada 116
IN - India 114
GB - Regno Unito 110
CI - Costa d'Avorio 62
AT - Austria 57
TR - Turchia 56
BD - Bangladesh 51
AR - Argentina 49
MX - Messico 36
NL - Olanda 35
IQ - Iraq 34
PK - Pakistan 34
EE - Estonia 33
ES - Italia 30
ID - Indonesia 26
SN - Senegal 26
CH - Svizzera 24
UZ - Uzbekistan 24
SA - Arabia Saudita 23
PL - Polonia 22
EC - Ecuador 20
VE - Venezuela 18
BE - Belgio 14
CZ - Repubblica Ceca 14
PY - Paraguay 14
ZA - Sudafrica 14
MA - Marocco 13
CL - Cile 12
GR - Grecia 12
AE - Emirati Arabi Uniti 11
OM - Oman 11
UA - Ucraina 11
CO - Colombia 10
MY - Malesia 10
AL - Albania 9
IE - Irlanda 9
IL - Israele 9
KE - Kenya 9
DZ - Algeria 8
KZ - Kazakistan 8
PE - Perù 8
PH - Filippine 8
TT - Trinidad e Tobago 8
UY - Uruguay 8
CR - Costa Rica 7
EG - Egitto 7
LT - Lituania 7
BO - Bolivia 6
IR - Iran 6
JM - Giamaica 6
NG - Nigeria 6
NZ - Nuova Zelanda 6
RO - Romania 5
AU - Australia 4
DO - Repubblica Dominicana 4
HN - Honduras 4
KW - Kuwait 4
SY - Repubblica araba siriana 4
BB - Barbados 3
BS - Bahamas 3
GE - Georgia 3
HU - Ungheria 3
JO - Giordania 3
KG - Kirghizistan 3
MO - Macao, regione amministrativa speciale della Cina 3
PA - Panama 3
PS - Palestinian Territory 3
PT - Portogallo 3
SK - Slovacchia (Repubblica Slovacca) 3
AM - Armenia 2
BY - Bielorussia 2
DK - Danimarca 2
MU - Mauritius 2
NP - Nepal 2
QA - Qatar 2
RS - Serbia 2
TH - Thailandia 2
TN - Tunisia 2
TW - Taiwan 2
AO - Angola 1
AZ - Azerbaigian 1
BH - Bahrain 1
CD - Congo 1
ET - Etiopia 1
GH - Ghana 1
Totale 14.923
Città #
Ashburn 846
Singapore 728
Hong Kong 651
Fairfield 539
Woodbridge 495
Santa Clara 461
San Jose 441
Dallas 362
Houston 359
Chandler 343
Seattle 257
Ann Arbor 239
Shanghai 226
Cambridge 213
Council Bluffs 202
Beijing 184
Wilmington 181
Sofia 174
Hefei 164
New York 146
Los Angeles 138
Serra 136
Ho Chi Minh City 135
Helsinki 134
Pisa 121
Seoul 114
Boardman 110
Tokyo 107
Milan 94
Princeton 88
Lawrence 76
Hanoi 75
Lauterbourg 74
Florence 70
Abidjan 62
Medford 58
Munich 57
Chicago 53
São Paulo 51
London 48
Ottawa 48
Des Moines 45
Redondo Beach 44
Frankfurt am Main 43
Vienna 40
Buffalo 39
Livorno 39
Istanbul 35
Bremen 34
Tallinn 33
Rome 30
Nanjing 27
Columbus 26
Dakar 26
San Diego 26
Dearborn 25
Boulder 24
Nuremberg 24
Tashkent 24
Turku 24
Phoenix 22
Rio de Janeiro 22
Dong Ket 21
Zurich 21
Lucca 20
Montreal 20
Denver 19
Fuzhou 19
Giussano 19
Ogden 19
Quanzhou 19
Da Nang 18
Fort Wayne 17
Kent 16
Chennai 15
Redwood City 15
Warsaw 15
Bologna 14
Mexico City 14
Orem 14
Paris 14
Amsterdam 13
Atlanta 13
Brasília 13
Brooklyn 13
San Francisco 13
Brussels 12
Turin 12
Vicopisano 12
Baghdad 11
Baltimore 11
Belo Horizonte 11
Lappeenranta 11
Salvador 11
San Giuliano Terme 11
Washington 11
Boston 10
Guangzhou 10
Hebei 10
Lahore 10
Totale 10.259
Nome #
Neurotrophic Activity and Its Modulation by Zinc Ion of a Dimeric Peptide Mimicking the Brain-Derived Neurotrophic Factor N-Terminal Region 552
Two mixed valence diruthenium(ii,iii) isomeric complexes show different anticancer properties 259
Photocytotoxic Pt(iv) complexes as prospective anticancer agents 253
A complex bearing TSPO PIGA ligand coordinated to the [Au(PEt3)]+ pharmacophore is highly cytotoxic against ovarian cancer cells 225
Iridium(I) Compounds as Prospective Anticancer Agents: Solution Chemistry, Antiproliferative Profiles and Protein Interactions for a Series of Iridium(I) N-Heterocyclic Carbene Complexes 225
Interaction of gold N-heterocyclic carbenes with nucleic acids 223
A mixed-valence diruthenium(ii,iii) complex endowed with high stability: from experimental evidence to theoretical interpretation 221
Auranofin and its Analogues Show Potent Antimicrobial Activity against Multidrug-Resistant Pathogens: Structure–Activity Relationships 210
Chlorido and bromido oxaliplatin analogues as potential agents for CRC treatment: Solution behavior, protein binding and cytotoxicity evaluation 209
Auranofin, Et3PAuCl, and Et3PAuI Are Highly Cytotoxic on Colorectal Cancer Cells: A Chemical and Biological Study 205
Interaction of a Gold(I) Dicarbene Anticancer Drug with Human Telomeric DNA G-Quadruplex: Solution and Computationally Aided X-ray Diffraction Analysis 203
PtI2(DACH), the Iodido Analogue of Oxaliplatin as a Candidate for Colorectal Cancer Treatment: Chemical and Biological Features 194
cis-Pt I2(NH3)2: a reappraisal 191
Cisplatin and its dibromido analogue: a comparison of chemical and biological profiles 190
Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts 190
Replacement of the Thiosugar of Auranofin with Iodide Enhances the Anticancer Potency in a Mouse Model of Ovarian Cancer 188
The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells 187
Protein Metalation by Anticancer Metallodrugs: A Joint ESI MS and XRD Investigative Strategy 183
A Fluorescent Silver(I) Carbene Complex with Anticancer Properties: Synthesis, Characterization, and Biological Studies 183
The leading established metal-based drugs: a revisitation of their relevant physico-chemical data 176
Medicinal Hypervalent Tellurium Prodrugs Bearing Different Ligands: A Comparative Study of the Chemical Profiles of AS101 and Its Halido Replaced Analogues 170
Gold(III) complexes with hydroxyquinoline, aminoquinoline and quinoline ligands: Synthesis, cytotoxicity, DNA and protein binding studies 170
Antiproliferative effects of two gold(I)-N-heterocyclic carbene complexes in A2780 human ovarian cancer cells: A comparative proteomic study 167
AS101: An overview on a leading tellurium-based prodrug 161
Oxaliplatin vs. cisplatin: Competition experiments on their binding to lysozyme 161
Biological applications of thiocarbohydrazones and their metal complexes: A perspective review 161
Cytotoxic Ag(I) and Au(I) NHC-carbenes bind DNA and show TrxR inhibition 161
The cisplatin/serum albumin system: A reappraisal 160
A first-in-class and a fished out anticancer platinum compound:: Cis -[PtCl2(NH3)2] and cis -[PtI2(NH3)2] compared for their reactivity towards DNA model systems 160
Cytotoxic activity and protein binding through an unusual oxidative mechanism by an iridium(I)–NHC complex 154
Interaction of anticancer Ru(III) complexes with single stranded and duplex DNA model systems 154
The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach 154
Peculiar features in the crystal structure of the adduct formed between cis-PtI2(NH3)2 and hen egg white lysozyme. 154
Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent 154
Triethylphosphine gold iodide (I), the iodido analogue of Auranofin: comparative studies of a potential antineoplastic agent 153
Synthesis, characterization and DNA interactions of [Pt3(TPymT)Cl3], the trinuclear platinum(II) complex of the TPymT ligand 152
Interactions of the organogold(III) compound Aubipyc with the copper chaperone Atox1: A joint mass spectrometry and circular dichroism investigation 150
Inorganic Drugs as a Tool for Protein Structure Solving and Studies on Conformational Changes 149
Description of a Non-Canonical AsPt Blue Species Originating from the Aerobic Oxidation of AP-1 in Aqueous Solution 148
Interactions between Anticancertrans-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of trans-(Dimethylamino)(methylamino)dichloridoplatinum(II) 148
Synthesis, DNA binding studies, and antiproliferative activity of novel Pt(II)-complexes with a L-alanyl-based ligand 147
Exploiting the Chemical Diversity of Metal Compounds as a Source of Novel Anti-COVID-19 Drugs 146
Mechanistic Insights Into the Anticancer Properties of the Auranofin Analog Au(PEt3)I: A Theoretical and Experimental Study 145
Anti-Staphylococcal Activity of the Auranofin Analogue Bearing Acetylcysteine in Place of the Thiosugar: An Experimental and Theoretical Investigation 144
Diruthenium(ii,iii) paddlewheel complexes: effects of bridging and axial ligands on anticancer properties 143
Mechanistic studies on cytotoxic gold compounds 142
Antimicrobial and Antibiofilm Activity of Auranofin and Its Two Derivatives Bearing Naproxen and Acetylcysteine as Ligands Against Staphylococci 142
A case of extensive protein platination: The reaction of lysozyme with a Pt(ii)-terpyridine complex 141
On the Different Mode of Action of Au(I)/Ag(I)-NHC Bis-Anthracenyl Complexes Towards Selected Target Biomolecules 141
Reactions of model proteins with aurothiomalate, a clinically established gold(I) drug: The comparison with auranofin 140
Oxaliplatin(IV) Prodrugs Functionalized with Gemcitabine and Capecitabine Induce Blockage of Colorectal Cancer Cell Growth - An Investigation of the Activation Mechanism and Their Nanoformulation 138
From conventional therapy to novel nano-based approaches. A focus on prostate cancer 138
Cancer Immunotherapy: An Overview on Small Molecules as Inhibitors of the Immune Checkpoint PD-1/PD-L1 (2015-2021) 138
Elucidating the reactivity of Pt(II) complexes with (O,S) bidentate ligands towards DNA model systems 137
Structural and solution chemistry, antiproliferative effects, and serum albumin binding of three pseudohalide derivatives of auranofin 136
Protein targets for anticancer metal based drugs 134
Interplay of crystallography, Raman microspectroscopy and electrospray mass spectrometry for studying the reaction between ruthenium complexes and proteins 134
Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding 134
An unprecedented palladium-arsenic catalytic cycle for nitriles hydration 131
Cisplatin binding to angiogenin protein: new molecular pathways and targets for the drug's anticancer activity 129
Non‐medical applications of inorganic medicines. A switch based on mechanistic knowledge 128
ESI–MS studies of the reactions of novel platinum(II) complexes containing O,O′-chelated acetylacetonate and sulfur ligands with selected model proteins 127
Synthesis and Mode of Action Studies on Iridium(I)–NHC Anticancer Drug Candidates 127
Reactions of cisplatin and cis-[PtI2(NH3)2] with molecular models of relevant protein sidechains: A comparative analysis 125
Ruthenium(II) 1,4,7-trithiacyclononane complexes of curcumin and bisdemethoxycurcumin: Synthesis, characterization, and biological activity 123
Mechanistic Evaluations of the Effects of Auranofin Triethylphosphine Replacement with a Trimethylphosphite Moiety 123
A Graphene Oxide-Angiogenin Theranostic Nanoplatform for the Therapeutic Targeting of Angiogenic Processes: The Effect of Copper-Supplemented Medium 121
Reactions of a tetranuclear Pt-thiosemicarbazone complex with model proteins 121
Reactions of Cytotoxic Metallodrugs with Lysozyme in pure DMSO explored through UV-Vis Absorption Spectroscopy and ESI MS 119
Protein Metalation by Inorganic Anticancer Drugs 119
Metallo therapeutics for COVID-19. Exploiting metal-based compounds for the discovery of new antiviral drugs 118
Angiogenin and copper crossing in wound healing 118
Pd-Based Hybrid Nanoparticles As Multimodal Theranostic Nanomedicine 116
Strategies for the improvement of metal-based chemotherapeutic treatments 115
Reactivity of antitumor coinage metal-based N-heterocyclic carbene complexes with cysteine and selenocysteine protein sites 111
Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA–PEG nanoparticles 111
New platinum(II) and palladium(II) complexes with substituted terpyridine ligands: synthesis and characterization, cytotoxicity and reactivity towards biomolecules 109
Peptides Derived from Angiogenin Regulate Cellular Copper Uptake 108
null 107
Reaction with Proteins of a Five-Coordinate Platinum(II) Compound 107
Drug repurposing meets DNA independent pathways: targeting alternative substrates for anticancer therapy 105
Auranofin and its analogs as prospective agents for the treatment of colorectal cancer 105
A Role for Metal-Based Drugs in Fighting COVID-19 Infection? The Case of Auranofin 104
The first step of arsenoplatin-1 aggregation in solution unveiled by solving the crystal structure of its protein adduct 104
Diruthenium Diacetate Catalysed Aerobic Oxidation of Hydroxylamines and Improved Chemoselectivity by Immobilisation to Lysozyme 102
Dimolybdenum (II,II) paddlewheel complexes bearing non-steroidal anti-inflammatory drug ligands: Insights into the chemico-physical profile and first biological assessment 101
Development of Effective Antibacterial Treatment: Lessons from the Past and Novel Approaches 98
Induction of a Four-Way Junction Structure in the DNA Palindromic Hexanucleotide 5′-d(CGTACG)-3′ by a Mononuclear Platinum Complex 97
In vitro anti-sars-cov-2 activity of selected metal compounds and potential molecular basis for their actions based on computational study 96
Tyrosine kinase inhibitors (TKIs) for ovarian cancer treatment: from organic to inorganic chemotherapeutics towards selectivity-a perspective overview 95
Unveiling the mechanism of activation of the Te(IV) prodrug AS101. New chemical insights towards a better understanding of its medicinal properties 94
Looking beyond dna as the target of inorganic chemotherapy agents: The key role of protein metalation and metal homeostasis 94
Reactions of Arsenoplatin-1 with Protein Targets: A Combined Experimental and Theoretical Study 94
The Effects on Angiogenesis of Relevant Inorganic Chemotherapeutics 91
Strike a balance: between metals and non-metals, metalloids as a source of anti-infective agents 90
The binding of auranofin at DNA/RNA nucleobases: A DFT assessment 87
Detailed mechanism of a DNA/RNA nucleobase substituting bridging ligand in diruthenium(ii,iii) and dirhodium(ii,ii) tetraacetato paddlewheel complexes: protonation of the leaving acetate is crucial 85
null 75
The metal(loid)s’ dilemma. What's the next step for a new era of inorganic molecules in medicine? 74
null 69
Totale 14.601
Categoria #
all - tutte 45.054
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 45.054


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022840 0 22 30 34 158 148 36 32 79 38 48 215
2022/20231.212 148 128 76 118 98 148 15 93 264 14 44 66
2023/2024909 42 60 69 33 119 125 140 57 22 24 74 144
2024/20253.501 21 117 15 236 308 355 352 171 373 440 408 705
2025/20264.964 301 636 526 563 372 364 747 306 380 448 144 177
2026/2027518 479 39 0 0 0 0 0 0 0 0 0 0
Totale 15.458