MARZO, TIZIANO
 Distribuzione geografica
Continente #
NA - Nord America 6.713
AS - Asia 4.199
EU - Europa 2.389
SA - Sud America 810
AF - Africa 153
OC - Oceania 10
AN - Antartide 1
Continente sconosciuto - Info sul continente non disponibili 1
Totale 14.276
Nazione #
US - Stati Uniti d'America 6.552
SG - Singapore 1.311
CN - Cina 1.073
IT - Italia 888
BR - Brasile 665
HK - Hong Kong 658
VN - Vietnam 468
SE - Svezia 273
FI - Finlandia 192
DE - Germania 191
BG - Bulgaria 173
FR - Francia 167
RU - Federazione Russa 122
KR - Corea 118
JP - Giappone 116
IN - India 111
GB - Regno Unito 98
CA - Canada 92
CI - Costa d'Avorio 62
AT - Austria 57
TR - Turchia 56
AR - Argentina 49
BD - Bangladesh 46
MX - Messico 35
IQ - Iraq 34
PK - Pakistan 34
EE - Estonia 33
NL - Olanda 31
ES - Italia 27
ID - Indonesia 26
SN - Senegal 26
CH - Svizzera 24
UZ - Uzbekistan 24
SA - Arabia Saudita 23
EC - Ecuador 20
PL - Polonia 18
VE - Venezuela 18
BE - Belgio 14
CZ - Repubblica Ceca 14
PY - Paraguay 14
ZA - Sudafrica 14
MA - Marocco 13
CL - Cile 12
GR - Grecia 12
AE - Emirati Arabi Uniti 11
OM - Oman 11
UA - Ucraina 11
CO - Colombia 10
MY - Malesia 10
AL - Albania 9
IE - Irlanda 9
IL - Israele 9
KE - Kenya 9
DZ - Algeria 8
KZ - Kazakistan 8
PE - Perù 8
PH - Filippine 8
UY - Uruguay 8
EG - Egitto 7
LT - Lituania 7
TT - Trinidad e Tobago 7
BO - Bolivia 6
IR - Iran 6
NG - Nigeria 6
NZ - Nuova Zelanda 6
JM - Giamaica 5
RO - Romania 5
AU - Australia 4
CR - Costa Rica 4
DO - Repubblica Dominicana 4
HN - Honduras 4
KW - Kuwait 4
SY - Repubblica araba siriana 4
GE - Georgia 3
HU - Ungheria 3
JO - Giordania 3
KG - Kirghizistan 3
MO - Macao, regione amministrativa speciale della Cina 3
PA - Panama 3
PS - Palestinian Territory 3
SK - Slovacchia (Repubblica Slovacca) 3
AM - Armenia 2
BB - Barbados 2
BS - Bahamas 2
BY - Bielorussia 2
MU - Mauritius 2
NP - Nepal 2
PT - Portogallo 2
QA - Qatar 2
RS - Serbia 2
TH - Thailandia 2
TN - Tunisia 2
TW - Taiwan 2
AO - Angola 1
AZ - Azerbaigian 1
BH - Bahrain 1
CD - Congo 1
DK - Danimarca 1
ET - Etiopia 1
GH - Ghana 1
Totale 14.267
Città #
Ashburn 738
Singapore 726
Hong Kong 651
Fairfield 539
Woodbridge 495
Santa Clara 444
San Jose 437
Houston 353
Chandler 343
Dallas 334
Seattle 255
Ann Arbor 239
Shanghai 226
Cambridge 213
Beijing 184
Wilmington 181
Council Bluffs 173
Sofia 173
Hefei 164
Ho Chi Minh City 135
Serra 135
Helsinki 134
New York 124
Pisa 119
Los Angeles 117
Seoul 114
Boardman 110
Tokyo 105
Princeton 88
Lawrence 76
Hanoi 75
Lauterbourg 74
Milan 71
Florence 66
Abidjan 62
Medford 58
Munich 57
Chicago 49
São Paulo 49
Ottawa 48
Des Moines 45
Redondo Beach 44
London 43
Vienna 40
Buffalo 39
Frankfurt am Main 39
Livorno 39
Istanbul 35
Bremen 34
Tallinn 33
Nanjing 27
Columbus 26
Dakar 26
San Diego 26
Dearborn 25
Boulder 24
Nuremberg 24
Tashkent 24
Turku 24
Rio de Janeiro 22
Dong Ket 21
Zurich 21
Lucca 20
Rome 20
Fuzhou 19
Giussano 19
Ogden 19
Quanzhou 19
Da Nang 18
Fort Wayne 16
Kent 16
Phoenix 16
Redwood City 15
Paris 14
Bologna 13
Brasília 13
Chennai 13
Mexico City 13
Amsterdam 12
Brussels 12
Montreal 12
Vicopisano 12
Baghdad 11
Baltimore 11
Belo Horizonte 11
Lappeenranta 11
Salvador 11
San Giuliano Terme 11
Turin 11
Warsaw 11
Washington 11
Guangzhou 10
Hebei 10
Lahore 10
Orem 10
Brno 9
Campinas 9
Falls Church 9
Haiphong 9
Hyderabad 9
Totale 9.910
Nome #
Two mixed valence diruthenium(ii,iii) isomeric complexes show different anticancer properties 254
Photocytotoxic Pt(iv) complexes as prospective anticancer agents 249
A complex bearing TSPO PIGA ligand coordinated to the [Au(PEt3)]+ pharmacophore is highly cytotoxic against ovarian cancer cells 223
Iridium(I) Compounds as Prospective Anticancer Agents: Solution Chemistry, Antiproliferative Profiles and Protein Interactions for a Series of Iridium(I) N-Heterocyclic Carbene Complexes 222
Interaction of gold N-heterocyclic carbenes with nucleic acids 220
A mixed-valence diruthenium(ii,iii) complex endowed with high stability: from experimental evidence to theoretical interpretation 215
Auranofin and its Analogues Show Potent Antimicrobial Activity against Multidrug-Resistant Pathogens: Structure–Activity Relationships 209
Chlorido and bromido oxaliplatin analogues as potential agents for CRC treatment: Solution behavior, protein binding and cytotoxicity evaluation 208
Neurotrophic Activity and Its Modulation by Zinc Ion of a Dimeric Peptide Mimicking the Brain-Derived Neurotrophic Factor N-Terminal Region 204
Interaction of a Gold(I) Dicarbene Anticancer Drug with Human Telomeric DNA G-Quadruplex: Solution and Computationally Aided X-ray Diffraction Analysis 201
Auranofin, Et3PAuCl, and Et3PAuI Are Highly Cytotoxic on Colorectal Cancer Cells: A Chemical and Biological Study 199
PtI2(DACH), the Iodido Analogue of Oxaliplatin as a Candidate for Colorectal Cancer Treatment: Chemical and Biological Features 192
cis-Pt I2(NH3)2: a reappraisal 190
Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts 188
Cisplatin and its dibromido analogue: a comparison of chemical and biological profiles 187
The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells 186
Protein Metalation by Anticancer Metallodrugs: A Joint ESI MS and XRD Investigative Strategy 182
Replacement of the Thiosugar of Auranofin with Iodide Enhances the Anticancer Potency in a Mouse Model of Ovarian Cancer 182
A Fluorescent Silver(I) Carbene Complex with Anticancer Properties: Synthesis, Characterization, and Biological Studies 180
The leading established metal-based drugs: a revisitation of their relevant physico-chemical data 172
Gold(III) complexes with hydroxyquinoline, aminoquinoline and quinoline ligands: Synthesis, cytotoxicity, DNA and protein binding studies 170
Antiproliferative effects of two gold(I)-N-heterocyclic carbene complexes in A2780 human ovarian cancer cells: A comparative proteomic study 164
Oxaliplatin vs. cisplatin: Competition experiments on their binding to lysozyme 161
Cytotoxic Ag(I) and Au(I) NHC-carbenes bind DNA and show TrxR inhibition 161
Medicinal Hypervalent Tellurium Prodrugs Bearing Different Ligands: A Comparative Study of the Chemical Profiles of AS101 and Its Halido Replaced Analogues 159
The cisplatin/serum albumin system: A reappraisal 159
A first-in-class and a fished out anticancer platinum compound:: Cis -[PtCl2(NH3)2] and cis -[PtI2(NH3)2] compared for their reactivity towards DNA model systems 159
Biological applications of thiocarbohydrazones and their metal complexes: A perspective review 158
AS101: An overview on a leading tellurium-based prodrug 156
Interaction of anticancer Ru(III) complexes with single stranded and duplex DNA model systems 154
The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach 154
Cytotoxic activity and protein binding through an unusual oxidative mechanism by an iridium(I)–NHC complex 153
Triethylphosphine gold iodide (I), the iodido analogue of Auranofin: comparative studies of a potential antineoplastic agent 153
Peculiar features in the crystal structure of the adduct formed between cis-PtI2(NH3)2 and hen egg white lysozyme. 153
Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent 153
Interactions of the organogold(III) compound Aubipyc with the copper chaperone Atox1: A joint mass spectrometry and circular dichroism investigation 150
Synthesis, characterization and DNA interactions of [Pt3(TPymT)Cl3], the trinuclear platinum(II) complex of the TPymT ligand 150
Inorganic Drugs as a Tool for Protein Structure Solving and Studies on Conformational Changes 148
Interactions between Anticancertrans-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of trans-(Dimethylamino)(methylamino)dichloridoplatinum(II) 148
Synthesis, DNA binding studies, and antiproliferative activity of novel Pt(II)-complexes with a L-alanyl-based ligand 146
Mechanistic Insights Into the Anticancer Properties of the Auranofin Analog Au(PEt3)I: A Theoretical and Experimental Study 145
Anti-Staphylococcal Activity of the Auranofin Analogue Bearing Acetylcysteine in Place of the Thiosugar: An Experimental and Theoretical Investigation 144
Diruthenium(ii,iii) paddlewheel complexes: effects of bridging and axial ligands on anticancer properties 141
A case of extensive protein platination: The reaction of lysozyme with a Pt(ii)-terpyridine complex 140
Mechanistic studies on cytotoxic gold compounds 140
Reactions of model proteins with aurothiomalate, a clinically established gold(I) drug: The comparison with auranofin 140
On the Different Mode of Action of Au(I)/Ag(I)-NHC Bis-Anthracenyl Complexes Towards Selected Target Biomolecules 140
Antimicrobial and Antibiofilm Activity of Auranofin and Its Two Derivatives Bearing Naproxen and Acetylcysteine as Ligands Against Staphylococci 140
Description of a Non-Canonical AsPt Blue Species Originating from the Aerobic Oxidation of AP-1 in Aqueous Solution 137
Exploiting the Chemical Diversity of Metal Compounds as a Source of Novel Anti-COVID-19 Drugs 136
Elucidating the reactivity of Pt(II) complexes with (O,S) bidentate ligands towards DNA model systems 136
Cancer Immunotherapy: An Overview on Small Molecules as Inhibitors of the Immune Checkpoint PD-1/PD-L1 (2015-2021) 136
Interplay of crystallography, Raman microspectroscopy and electrospray mass spectrometry for studying the reaction between ruthenium complexes and proteins 134
Structural and solution chemistry, antiproliferative effects, and serum albumin binding of three pseudohalide derivatives of auranofin 134
Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding 133
Protein targets for anticancer metal based drugs 131
Cisplatin binding to angiogenin protein: new molecular pathways and targets for the drug's anticancer activity 129
Oxaliplatin(IV) Prodrugs Functionalized with Gemcitabine and Capecitabine Induce Blockage of Colorectal Cancer Cell Growth - An Investigation of the Activation Mechanism and Their Nanoformulation 127
ESI–MS studies of the reactions of novel platinum(II) complexes containing O,O′-chelated acetylacetonate and sulfur ligands with selected model proteins 127
An unprecedented palladium-arsenic catalytic cycle for nitriles hydration 126
Synthesis and Mode of Action Studies on Iridium(I)–NHC Anticancer Drug Candidates 126
Reactions of cisplatin and cis-[PtI2(NH3)2] with molecular models of relevant protein sidechains: A comparative analysis 125
Non‐medical applications of inorganic medicines. A switch based on mechanistic knowledge 123
Ruthenium(II) 1,4,7-trithiacyclononane complexes of curcumin and bisdemethoxycurcumin: Synthesis, characterization, and biological activity 123
Mechanistic Evaluations of the Effects of Auranofin Triethylphosphine Replacement with a Trimethylphosphite Moiety 123
From conventional therapy to novel nano-based approaches. A focus on prostate cancer 122
A Graphene Oxide-Angiogenin Theranostic Nanoplatform for the Therapeutic Targeting of Angiogenic Processes: The Effect of Copper-Supplemented Medium 121
Reactions of a tetranuclear Pt-thiosemicarbazone complex with model proteins 120
Reactions of Cytotoxic Metallodrugs with Lysozyme in pure DMSO explored through UV-Vis Absorption Spectroscopy and ESI MS 118
Protein Metalation by Inorganic Anticancer Drugs 118
Metallo therapeutics for COVID-19. Exploiting metal-based compounds for the discovery of new antiviral drugs 117
Angiogenin and copper crossing in wound healing 117
Strategies for the improvement of metal-based chemotherapeutic treatments 114
Pd-Based Hybrid Nanoparticles As Multimodal Theranostic Nanomedicine 113
Reactivity of antitumor coinage metal-based N-heterocyclic carbene complexes with cysteine and selenocysteine protein sites 110
New platinum(II) and palladium(II) complexes with substituted terpyridine ligands: synthesis and characterization, cytotoxicity and reactivity towards biomolecules 108
null 107
Reaction with Proteins of a Five-Coordinate Platinum(II) Compound 107
Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA–PEG nanoparticles 106
Auranofin and its analogs as prospective agents for the treatment of colorectal cancer 105
A Role for Metal-Based Drugs in Fighting COVID-19 Infection? The Case of Auranofin 104
Peptides Derived from Angiogenin Regulate Cellular Copper Uptake 104
The first step of arsenoplatin-1 aggregation in solution unveiled by solving the crystal structure of its protein adduct 103
Drug repurposing meets DNA independent pathways: targeting alternative substrates for anticancer therapy 103
Diruthenium Diacetate Catalysed Aerobic Oxidation of Hydroxylamines and Improved Chemoselectivity by Immobilisation to Lysozyme 97
Induction of a Four-Way Junction Structure in the DNA Palindromic Hexanucleotide 5′-d(CGTACG)-3′ by a Mononuclear Platinum Complex 97
In vitro anti-sars-cov-2 activity of selected metal compounds and potential molecular basis for their actions based on computational study 96
Development of Effective Antibacterial Treatment: Lessons from the Past and Novel Approaches 96
Reactions of Arsenoplatin-1 with Protein Targets: A Combined Experimental and Theoretical Study 94
Looking beyond dna as the target of inorganic chemotherapy agents: The key role of protein metalation and metal homeostasis 93
Unveiling the mechanism of activation of the Te(IV) prodrug AS101. New chemical insights towards a better understanding of its medicinal properties 91
The Effects on Angiogenesis of Relevant Inorganic Chemotherapeutics 91
Tyrosine kinase inhibitors (TKIs) for ovarian cancer treatment: from organic to inorganic chemotherapeutics towards selectivity-a perspective overview 90
Strike a balance: between metals and non-metals, metalloids as a source of anti-infective agents 90
Dimolybdenum (II,II) paddlewheel complexes bearing non-steroidal anti-inflammatory drug ligands: Insights into the chemico-physical profile and first biological assessment 89
The binding of auranofin at DNA/RNA nucleobases: A DFT assessment 84
Detailed mechanism of a DNA/RNA nucleobase substituting bridging ligand in diruthenium(ii,iii) and dirhodium(ii,ii) tetraacetato paddlewheel complexes: protonation of the leaving acetate is crucial 83
null 75
null 69
The metal(loid)s’ dilemma. What's the next step for a new era of inorganic molecules in medicine? 67
Totale 14.027
Categoria #
all - tutte 42.777
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 42.777


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021129 0 0 0 0 0 0 0 0 0 0 0 129
2021/2022874 34 22 30 34 158 148 36 32 79 38 48 215
2022/20231.212 148 128 76 118 98 148 15 93 264 14 44 66
2023/2024909 42 60 69 33 119 125 140 57 22 24 74 144
2024/20253.501 21 117 15 236 308 355 352 171 373 440 408 705
2025/20264.818 301 636 526 563 372 364 747 306 380 448 144 31
Totale 14.794