MARZO, TIZIANO
 Distribuzione geografica
Continente #
NA - Nord America 5.771
AS - Asia 3.454
EU - Europa 2.041
SA - Sud America 752
AF - Africa 141
OC - Oceania 9
AN - Antartide 1
Continente sconosciuto - Info sul continente non disponibili 1
Totale 12.170
Nazione #
US - Stati Uniti d'America 5.639
SG - Singapore 1.113
CN - Cina 964
IT - Italia 821
BR - Brasile 627
HK - Hong Kong 602
VN - Vietnam 276
SE - Svezia 272
BG - Bulgaria 173
DE - Germania 173
RU - Federazione Russa 119
KR - Corea 118
GB - Regno Unito 87
IN - India 85
FR - Francia 79
CA - Canada 78
FI - Finlandia 73
CI - Costa d'Avorio 61
AT - Austria 54
AR - Argentina 48
TR - Turchia 48
JP - Giappone 37
EE - Estonia 33
BD - Bangladesh 30
ES - Italia 27
PK - Pakistan 27
MX - Messico 26
SN - Senegal 26
NL - Olanda 24
IQ - Iraq 22
ID - Indonesia 21
EC - Ecuador 18
PL - Polonia 17
UZ - Uzbekistan 16
SA - Arabia Saudita 15
BE - Belgio 14
CZ - Repubblica Ceca 14
PY - Paraguay 14
GR - Grecia 12
MA - Marocco 12
VE - Venezuela 12
OM - Oman 11
UA - Ucraina 11
ZA - Sudafrica 11
CL - Cile 8
IL - Israele 8
UY - Uruguay 8
AE - Emirati Arabi Uniti 7
AL - Albania 7
EG - Egitto 7
KE - Kenya 7
KZ - Kazakistan 7
LT - Lituania 7
MY - Malesia 7
TT - Trinidad e Tobago 7
CO - Colombia 6
DZ - Algeria 6
IE - Irlanda 6
IR - Iran 6
PE - Perù 6
BO - Bolivia 5
NG - Nigeria 5
NZ - Nuova Zelanda 5
RO - Romania 5
AU - Australia 4
JM - Giamaica 4
KW - Kuwait 4
CH - Svizzera 3
DO - Repubblica Dominicana 3
HN - Honduras 3
MO - Macao, regione amministrativa speciale della Cina 3
PA - Panama 3
PH - Filippine 3
PS - Palestinian Territory 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
AM - Armenia 2
BB - Barbados 2
BS - Bahamas 2
CR - Costa Rica 2
GE - Georgia 2
JO - Giordania 2
KG - Kirghizistan 2
PT - Portogallo 2
QA - Qatar 2
RS - Serbia 2
TN - Tunisia 2
AO - Angola 1
AZ - Azerbaigian 1
BH - Bahrain 1
BY - Bielorussia 1
CD - Congo 1
DK - Danimarca 1
GH - Ghana 1
GS - Georgia del Sud e Isole Sandwich Australi 1
GT - Guatemala 1
KH - Cambogia 1
LB - Libano 1
LI - Liechtenstein 1
MN - Mongolia 1
Totale 12.164
Città #
Ashburn 661
Hong Kong 599
Singapore 577
Fairfield 539
Woodbridge 495
Santa Clara 437
Houston 352
Chandler 343
Dallas 332
Seattle 253
Ann Arbor 239
Shanghai 223
Cambridge 213
Wilmington 181
Beijing 177
Sofia 173
Hefei 164
Serra 135
New York 118
Pisa 115
Seoul 114
Boardman 110
Los Angeles 93
Princeton 88
Lawrence 76
Ho Chi Minh City 73
Florence 65
Milan 64
Abidjan 61
Medford 58
Munich 57
Ottawa 48
Chicago 47
São Paulo 46
Des Moines 44
Redondo Beach 44
Council Bluffs 41
London 41
Vienna 38
Buffalo 37
Livorno 37
Bremen 34
Istanbul 33
Tallinn 33
Hanoi 32
Frankfurt am Main 27
Nanjing 27
Dakar 26
Tokyo 26
Dearborn 25
Boulder 24
Turku 24
San Diego 23
Rio de Janeiro 22
Dong Ket 21
Nuremberg 21
Lucca 20
Fuzhou 19
Giussano 19
Ogden 19
Quanzhou 19
San Jose 18
Kent 16
Tashkent 16
Fort Wayne 15
Helsinki 15
Redwood City 15
Paris 14
Phoenix 14
Brasília 13
Columbus 13
Brussels 12
Rome 12
Vicopisano 12
Lappeenranta 11
Salvador 11
Belo Horizonte 10
Chennai 10
Hebei 10
Montreal 10
San Giuliano Terme 10
Warsaw 10
Bologna 9
Brno 9
Falls Church 9
Guangzhou 9
Mexico City 9
Porto Alegre 9
Turin 9
Washington 9
Boston 8
Buenos Aires 8
Campinas 8
Hyderabad 8
Madrid 8
Manaus 8
Napoli 8
Norwalk 8
Pelotas 8
Shenyang 8
Totale 8.521
Nome #
Two mixed valence diruthenium(ii,iii) isomeric complexes show different anticancer properties 212
Iridium(I) Compounds as Prospective Anticancer Agents: Solution Chemistry, Antiproliferative Profiles and Protein Interactions for a Series of Iridium(I) N-Heterocyclic Carbene Complexes 211
Photocytotoxic Pt(iv) complexes as prospective anticancer agents 211
Chlorido and bromido oxaliplatin analogues as potential agents for CRC treatment: Solution behavior, protein binding and cytotoxicity evaluation 193
Interaction of gold N-heterocyclic carbenes with nucleic acids 191
Neurotrophic Activity and Its Modulation by Zinc Ion of a Dimeric Peptide Mimicking the Brain-Derived Neurotrophic Factor N-Terminal Region 183
PtI2(DACH), the Iodido Analogue of Oxaliplatin as a Candidate for Colorectal Cancer Treatment: Chemical and Biological Features 180
Auranofin and its Analogues Show Potent Antimicrobial Activity against Multidrug-Resistant Pathogens: Structure–Activity Relationships 180
Cisplatin and its dibromido analogue: a comparison of chemical and biological profiles 178
Interaction of a Gold(I) Dicarbene Anticancer Drug with Human Telomeric DNA G-Quadruplex: Solution and Computationally Aided X-ray Diffraction Analysis 177
cis-Pt I2(NH3)2: a reappraisal 175
Protein Metalation by Anticancer Metallodrugs: A Joint ESI MS and XRD Investigative Strategy 175
Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts 172
Auranofin, Et3PAuCl, and Et3PAuI Are Highly Cytotoxic on Colorectal Cancer Cells: A Chemical and Biological Study 169
The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells 168
Gold(III) complexes with hydroxyquinoline, aminoquinoline and quinoline ligands: Synthesis, cytotoxicity, DNA and protein binding studies 162
A mixed-valence diruthenium(ii,iii) complex endowed with high stability: from experimental evidence to theoretical interpretation 161
Replacement of the Thiosugar of Auranofin with Iodide Enhances the Anticancer Potency in a Mouse Model of Ovarian Cancer 156
A Fluorescent Silver(I) Carbene Complex with Anticancer Properties: Synthesis, Characterization, and Biological Studies 154
A complex bearing TSPO PIGA ligand coordinated to the [Au(PEt3)]+ pharmacophore is highly cytotoxic against ovarian cancer cells 153
The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach 150
Oxaliplatin vs. cisplatin: Competition experiments on their binding to lysozyme 148
The leading established metal-based drugs: a revisitation of their relevant physico-chemical data 146
Cytotoxic Ag(I) and Au(I) NHC-carbenes bind DNA and show TrxR inhibition 146
Interactions of the organogold(III) compound Aubipyc with the copper chaperone Atox1: A joint mass spectrometry and circular dichroism investigation 145
Peculiar features in the crystal structure of the adduct formed between cis-PtI2(NH3)2 and hen egg white lysozyme. 145
Interaction of anticancer Ru(III) complexes with single stranded and duplex DNA model systems 143
The cisplatin/serum albumin system: A reappraisal 143
A first-in-class and a fished out anticancer platinum compound:: Cis -[PtCl2(NH3)2] and cis -[PtI2(NH3)2] compared for their reactivity towards DNA model systems 143
Cytotoxic activity and protein binding through an unusual oxidative mechanism by an iridium(I)–NHC complex 142
Triethylphosphine gold iodide (I), the iodido analogue of Auranofin: comparative studies of a potential antineoplastic agent 140
Synthesis, DNA binding studies, and antiproliferative activity of novel Pt(II)-complexes with a L-alanyl-based ligand 140
Antiproliferative effects of two gold(I)-N-heterocyclic carbene complexes in A2780 human ovarian cancer cells: A comparative proteomic study 139
Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent 138
Biological applications of thiocarbohydrazones and their metal complexes: A perspective review 137
Medicinal Hypervalent Tellurium Prodrugs Bearing Different Ligands: A Comparative Study of the Chemical Profiles of AS101 and Its Halido Replaced Analogues 134
Synthesis, characterization and DNA interactions of [Pt3(TPymT)Cl3], the trinuclear platinum(II) complex of the TPymT ligand 134
Interactions between Anticancertrans-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of trans-(Dimethylamino)(methylamino)dichloridoplatinum(II) 131
Reactions of model proteins with aurothiomalate, a clinically established gold(I) drug: The comparison with auranofin 131
AS101: An overview on a leading tellurium-based prodrug 130
Elucidating the reactivity of Pt(II) complexes with (O,S) bidentate ligands towards DNA model systems 128
Structural and solution chemistry, antiproliferative effects, and serum albumin binding of three pseudohalide derivatives of auranofin 128
On the Different Mode of Action of Au(I)/Ag(I)-NHC Bis-Anthracenyl Complexes Towards Selected Target Biomolecules 128
Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding 127
Mechanistic studies on cytotoxic gold compounds 125
Mechanistic Insights Into the Anticancer Properties of the Auranofin Analog Au(PEt3)I: A Theoretical and Experimental Study 124
Interplay of crystallography, Raman microspectroscopy and electrospray mass spectrometry for studying the reaction between ruthenium complexes and proteins 123
Inorganic Drugs as a Tool for Protein Structure Solving and Studies on Conformational Changes 121
A case of extensive protein platination: The reaction of lysozyme with a Pt(ii)-terpyridine complex 120
Anti-Staphylococcal Activity of the Auranofin Analogue Bearing Acetylcysteine in Place of the Thiosugar: An Experimental and Theoretical Investigation 120
ESI–MS studies of the reactions of novel platinum(II) complexes containing O,O′-chelated acetylacetonate and sulfur ligands with selected model proteins 118
Exploiting the Chemical Diversity of Metal Compounds as a Source of Novel Anti-COVID-19 Drugs 115
Diruthenium(ii,iii) paddlewheel complexes: effects of bridging and axial ligands on anticancer properties 115
Synthesis and Mode of Action Studies on Iridium(I)–NHC Anticancer Drug Candidates 111
Reactions of a tetranuclear Pt-thiosemicarbazone complex with model proteins 110
Metallo therapeutics for COVID-19. Exploiting metal-based compounds for the discovery of new antiviral drugs 110
Description of a Non-Canonical AsPt Blue Species Originating from the Aerobic Oxidation of AP-1 in Aqueous Solution 109
Reactions of Cytotoxic Metallodrugs with Lysozyme in pure DMSO explored through UV-Vis Absorption Spectroscopy and ESI MS 109
null 107
Protein Metalation by Inorganic Anticancer Drugs 107
Protein targets for anticancer metal based drugs 106
A Graphene Oxide-Angiogenin Theranostic Nanoplatform for the Therapeutic Targeting of Angiogenic Processes: The Effect of Copper-Supplemented Medium 105
Reactions of cisplatin and cis-[PtI2(NH3)2] with molecular models of relevant protein sidechains: A comparative analysis 105
Strategies for the improvement of metal-based chemotherapeutic treatments 105
Mechanistic Evaluations of the Effects of Auranofin Triethylphosphine Replacement with a Trimethylphosphite Moiety 105
Cisplatin binding to angiogenin protein: new molecular pathways and targets for the drug's anticancer activity 104
New platinum(II) and palladium(II) complexes with substituted terpyridine ligands: synthesis and characterization, cytotoxicity and reactivity towards biomolecules 103
An unprecedented palladium-arsenic catalytic cycle for nitriles hydration 102
Ruthenium(II) 1,4,7-trithiacyclononane complexes of curcumin and bisdemethoxycurcumin: Synthesis, characterization, and biological activity 101
Pd-Based Hybrid Nanoparticles As Multimodal Theranostic Nanomedicine 100
Reaction with Proteins of a Five-Coordinate Platinum(II) Compound 98
The first step of arsenoplatin-1 aggregation in solution unveiled by solving the crystal structure of its protein adduct 98
Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA–PEG nanoparticles 95
Oxaliplatin(IV) Prodrugs Functionalized with Gemcitabine and Capecitabine Induce Blockage of Colorectal Cancer Cell Growth - An Investigation of the Activation Mechanism and Their Nanoformulation 94
From conventional therapy to novel nano-based approaches. A focus on prostate cancer 92
A Role for Metal-Based Drugs in Fighting COVID-19 Infection? The Case of Auranofin 92
Cancer Immunotherapy: An Overview on Small Molecules as Inhibitors of the Immune Checkpoint PD-1/PD-L1 (2015-2021) 92
Drug repurposing meets DNA independent pathways: targeting alternative substrates for anticancer therapy 89
Auranofin and its analogs as prospective agents for the treatment of colorectal cancer 89
Diruthenium Diacetate Catalysed Aerobic Oxidation of Hydroxylamines and Improved Chemoselectivity by Immobilisation to Lysozyme 88
Development of Effective Antibacterial Treatment: Lessons from the Past and Novel Approaches 88
Angiogenin and copper crossing in wound healing 87
Reactivity of antitumor coinage metal-based N-heterocyclic carbene complexes with cysteine and selenocysteine protein sites 87
Induction of a Four-Way Junction Structure in the DNA Palindromic Hexanucleotide 5′-d(CGTACG)-3′ by a Mononuclear Platinum Complex 84
The Effects on Angiogenesis of Relevant Inorganic Chemotherapeutics 84
Looking beyond dna as the target of inorganic chemotherapy agents: The key role of protein metalation and metal homeostasis 84
Antimicrobial and Antibiofilm Activity of Auranofin and Its Two Derivatives Bearing Naproxen and Acetylcysteine as Ligands Against Staphylococci 83
Non‐medical applications of inorganic medicines. A switch based on mechanistic knowledge 82
In vitro anti-sars-cov-2 activity of selected metal compounds and potential molecular basis for their actions based on computational study 80
Strike a balance: between metals and non-metals, metalloids as a source of anti-infective agents 80
Reactions of Arsenoplatin-1 with Protein Targets: A Combined Experimental and Theoretical Study 78
Peptides Derived from Angiogenin Regulate Cellular Copper Uptake 77
null 75
Dimolybdenum (II,II) paddlewheel complexes bearing non-steroidal anti-inflammatory drug ligands: Insights into the chemico-physical profile and first biological assessment 74
Unveiling the mechanism of activation of the Te(IV) prodrug AS101. New chemical insights towards a better understanding of its medicinal properties 73
Tyrosine kinase inhibitors (TKIs) for ovarian cancer treatment: from organic to inorganic chemotherapeutics towards selectivity-a perspective overview 70
null 69
The binding of auranofin at DNA/RNA nucleobases: A DFT assessment 61
Detailed mechanism of a DNA/RNA nucleobase substituting bridging ligand in diruthenium(ii,iii) and dirhodium(ii,ii) tetraacetato paddlewheel complexes: protonation of the leaving acetate is crucial 56
null 55
Totale 12.211
Categoria #
all - tutte 38.063
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 38.063


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021568 0 0 0 0 0 44 30 58 179 65 63 129
2021/2022874 34 22 30 34 158 148 36 32 79 38 48 215
2022/20231.212 148 128 76 118 98 148 15 93 264 14 44 66
2023/2024909 42 60 69 33 119 125 140 57 22 24 74 144
2024/20253.501 21 117 15 236 308 355 352 171 373 440 408 705
2025/20262.702 301 636 526 563 372 304 0 0 0 0 0 0
Totale 12.678