Tumors have long been known to rewire their metabolism to endorse their proliferation, growth, survival, and invasiveness. One of the common characteristics of these alterations is the enhanced glucose uptake and its subsequent transformation into lactic acid by means of glycolysis, regardless the availability of oxygen or the mitochondria effectiveness. This phenomenon is called the “Warburg effect”, which has turned into a century of age now, since its first disclosure by German physiologist Otto Heinrich Warburg. Since then, this peculiar metabolic switch in tumors has been addressed by extensive studies covering several areas of research. In this historical perspective, we aim at illustrating the evolution of these studies over time and their implication in various fields of science.
Historical perspective of tumor glycolysis: a century with Otto Warburg
Bononi, GiuliaPrimo
;Masoni, Samuele;Di Bussolo, Valeria;Tuccinardi, Tiziano;Granchi, Carlotta;Minutolo, Filippo
Ultimo
2022-01-01
Abstract
Tumors have long been known to rewire their metabolism to endorse their proliferation, growth, survival, and invasiveness. One of the common characteristics of these alterations is the enhanced glucose uptake and its subsequent transformation into lactic acid by means of glycolysis, regardless the availability of oxygen or the mitochondria effectiveness. This phenomenon is called the “Warburg effect”, which has turned into a century of age now, since its first disclosure by German physiologist Otto Heinrich Warburg. Since then, this peculiar metabolic switch in tumors has been addressed by extensive studies covering several areas of research. In this historical perspective, we aim at illustrating the evolution of these studies over time and their implication in various fields of science.File | Dimensione | Formato | |
---|---|---|---|
Tumor Glycolysis_historical perspective_pre-print.pdf
accesso aperto
Descrizione: bozza autori
Tipologia:
Documento in Pre-print
Licenza:
Creative commons
Dimensione
669.06 kB
Formato
Adobe PDF
|
669.06 kB | Adobe PDF | Visualizza/Apri |
YSCBI-D-22-00065_post-print.pdf
Open Access dal 02/10/2023
Descrizione: versione post-referaggio
Tipologia:
Documento in Post-print
Licenza:
Creative commons
Dimensione
1.32 MB
Formato
Adobe PDF
|
1.32 MB | Adobe PDF | Visualizza/Apri |
Historical_perspective_SemCancBio_2022.pdf
solo utenti autorizzati
Tipologia:
Versione finale editoriale
Licenza:
NON PUBBLICO - accesso privato/ristretto
Dimensione
2.46 MB
Formato
Adobe PDF
|
2.46 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.