Tumors have long been known to rewire their metabolism to endorse their proliferation, growth, survival, and invasiveness. One of the common characteristics of these alterations is the enhanced glucose uptake and its subsequent transformation into lactic acid by means of glycolysis, regardless the availability of oxygen or the mitochondria effectiveness. This phenomenon is called the “Warburg effect”, which has turned into a century of age now, since its first disclosure by German physiologist Otto Heinrich Warburg. Since then, this peculiar metabolic switch in tumors has been addressed by extensive studies covering several areas of research. In this historical perspective, we aim at illustrating the evolution of these studies over time and their implication in various fields of science.

Historical perspective of tumor glycolysis: a century with Otto Warburg

Bononi, Giulia
Primo
;
Masoni, Samuele;Di Bussolo, Valeria;Tuccinardi, Tiziano;Granchi, Carlotta;Minutolo, Filippo
Ultimo
2022-01-01

Abstract

Tumors have long been known to rewire their metabolism to endorse their proliferation, growth, survival, and invasiveness. One of the common characteristics of these alterations is the enhanced glucose uptake and its subsequent transformation into lactic acid by means of glycolysis, regardless the availability of oxygen or the mitochondria effectiveness. This phenomenon is called the “Warburg effect”, which has turned into a century of age now, since its first disclosure by German physiologist Otto Heinrich Warburg. Since then, this peculiar metabolic switch in tumors has been addressed by extensive studies covering several areas of research. In this historical perspective, we aim at illustrating the evolution of these studies over time and their implication in various fields of science.
2022
Bononi, Giulia; Masoni, Samuele; Di Bussolo, Valeria; Tuccinardi, Tiziano; Granchi, Carlotta; Minutolo, Filippo
File in questo prodotto:
File Dimensione Formato  
Tumor Glycolysis_historical perspective_pre-print.pdf

accesso aperto

Descrizione: bozza autori
Tipologia: Documento in Pre-print
Licenza: Creative commons
Dimensione 669.06 kB
Formato Adobe PDF
669.06 kB Adobe PDF Visualizza/Apri
YSCBI-D-22-00065_post-print.pdf

Open Access dal 02/10/2023

Descrizione: versione post-referaggio
Tipologia: Documento in Post-print
Licenza: Creative commons
Dimensione 1.32 MB
Formato Adobe PDF
1.32 MB Adobe PDF Visualizza/Apri
Historical_perspective_SemCancBio_2022.pdf

solo utenti autorizzati

Tipologia: Versione finale editoriale
Licenza: NON PUBBLICO - accesso privato/ristretto
Dimensione 2.46 MB
Formato Adobe PDF
2.46 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1148139
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 32
  • ???jsp.display-item.citation.isi??? 28
social impact