A series of 1,8-naphthyridine derivatives bearing various substituents in position 3, 4, and 7 of the heterocyclic nucleus have been synthesized and evaluated for their affinity at the bovine and human adenosine receptors. The new compounds were found to lack the affinity toward A1AR, whereas many of them are able to acquire an interesting affinity and selectivity for the A2AAR.
1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors.
MANERA, CLEMENTINA;BETTI, LAURA;GIANNACCINI, GINO;MARTINELLI, ADRIANO;G. ORTORE;SACCOMANNI, GIUSEPPE;TRINCAVELLI, MARIA LETIZIA;TUCCINARDI, TIZIANO;
2005-01-01
Abstract
A series of 1,8-naphthyridine derivatives bearing various substituents in position 3, 4, and 7 of the heterocyclic nucleus have been synthesized and evaluated for their affinity at the bovine and human adenosine receptors. The new compounds were found to lack the affinity toward A1AR, whereas many of them are able to acquire an interesting affinity and selectivity for the A2AAR.File in questo prodotto:
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