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EnglishThis work aimed to determine the enantioselectivity in cardioprotection induced by the racemic mixture of the "archetype" 1a of a new class of spirocyclic-benzopyran derivatives. The racemate was resolved by HPLC and the absolute configuration was accomplished by a combined strategy based on single-crystal X-ray diffraction and circular dichroism methods. The (S)-(-)-1a enantiomer, evaluated for its anti-ischemic activity, showed significant cardioprotective effects, whereas the (R)-(+)-1a enantiomer was completely lacking in anti-ischemic effects
| Autori interni: | ||
| Autori: | RAPPOSELLI S; CALDERONE V; CIRILLI R; DIGIACOMO M; FAGGI C; TORRE F.L.; MANGANARO M; MARTELLI A; TESTAI L | |
| Titolo: | Enantioselectivity in Cardioprotection induced by (S)- (-)-2,2-Dimethyl-N-(4'-acetamido-benzyl)-4-spiromorpholone-chromane | |
| Anno del prodotto: | 2009 | |
| Digital Object Identifier (DOI): | 10.1021/jm801459f | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11568/196411
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