The right keys for tumour locks: Nitroaromatic and heteroaromatic portions are suitably sensitive to hypoxic conditions when used as BAPN masking groups, and the resulting prodrugs (pro-BAPNs) showed good levels of in vitro hypoxia-selective inhibition of lysyl oxidase (LOX) activity and cancer cell invasion.
Bioreductively Activated Lysyl Oxidase Inhibitors against Hypoxic Tumours
GRANCHI, CARLOTTA;FUNAIOLI, TIZIANA;MACCHIA, MARCO;MINUTOLO, FILIPPO
2009-01-01
Abstract
The right keys for tumour locks: Nitroaromatic and heteroaromatic portions are suitably sensitive to hypoxic conditions when used as BAPN masking groups, and the resulting prodrugs (pro-BAPNs) showed good levels of in vitro hypoxia-selective inhibition of lysyl oxidase (LOX) activity and cancer cell invasion.File in questo prodotto:
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