Aging is characterized by dynamic changes at metabolic level that lead to modifications in the composition of the metabolome. Since the identification of biomarkers that can discriminate people of different age and health status has recently attracted a great inter- est, we wondered whether age-specific changes in the metabolome could be identified and serve as new and informative biomarkers of aging and longevity. In the last few years, a specific branch of metabonomics de- voted to the study of volatile organic compounds (VOCs) has been developed. To date, little is known about the profile of specific VOCs in healthy aging and longevity in humans; therefore, we investigated the profile of VOCs in both urine and feces samples from 73 volunteers of different age including centenarians that represent useful “super-controls” to identify poten- tial biomarkers of successful aging and footprints of longevity. To this purpose, we performed a discriminant analysis by which we were able to identify specific profiles of urinary and fecal VOCs. Such profiles can discriminate different age groups, from young to cente- narians, and, even more interesting, centenarians’ off- spring from age-matched controls. Moreover, we were able to identify VOCs that are specific for the couples “centenarians – offspring” or the trios “centenarians – offspring – spouse,” suggesting the possible existence of a familiar component also for VOCs profile.

The smell of longevity: a combination of Volatile Organic Compounds (VOCs) can discriminate centenarians and their offspring from age-matched subjects and young controls

Conte, Giuseppe;Casarosa, Laura;Serra, Andrea;Mele, Marcello;
2020-01-01

Abstract

Aging is characterized by dynamic changes at metabolic level that lead to modifications in the composition of the metabolome. Since the identification of biomarkers that can discriminate people of different age and health status has recently attracted a great inter- est, we wondered whether age-specific changes in the metabolome could be identified and serve as new and informative biomarkers of aging and longevity. In the last few years, a specific branch of metabonomics de- voted to the study of volatile organic compounds (VOCs) has been developed. To date, little is known about the profile of specific VOCs in healthy aging and longevity in humans; therefore, we investigated the profile of VOCs in both urine and feces samples from 73 volunteers of different age including centenarians that represent useful “super-controls” to identify poten- tial biomarkers of successful aging and footprints of longevity. To this purpose, we performed a discriminant analysis by which we were able to identify specific profiles of urinary and fecal VOCs. Such profiles can discriminate different age groups, from young to cente- narians, and, even more interesting, centenarians’ off- spring from age-matched controls. Moreover, we were able to identify VOCs that are specific for the couples “centenarians – offspring” or the trios “centenarians – offspring – spouse,” suggesting the possible existence of a familiar component also for VOCs profile.
2020
Conte, Maria; Conte, Giuseppe; Martucci, Morena; Monti, Daniela; Casarosa, Laura; Serra, Andrea; Mele, Marcello; Franceschi, Claudio; Salvioli, Stefan...espandi
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1015945
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 7
social impact