Resveratrol, a natural product with a stilbene structure, exerts profound proapoptotic activity in human cancer cells, by triggering the accumulation of ceramide, a bioactive sphingolipid. We studied the biological effects of seven methoxylated and/or naphthalene-based resveratrol analogues and compared these compounds with resveratrol with the objective to identify an analogue with higher ceramide-mediated proapoptotic activity relative to resveratrol. Here we show that the compound with three hydroxyls and a naphthalene ring is the most effective in triggering apoptosis coupled to the induction of endogenous ceramide in human cancer cells.

Synthesis of a Resveratrol Analogue with High Ceramide-Mediated Proapoptotic Activity on Human Breast Cancer Cells

MINUTOLO, FILIPPO;BERTINI, SIMONE;PLACANICA, GIORGIO;RAPPOSELLI, SIMONA;MACCHIA, MARCO;
2005-01-01

Abstract

Resveratrol, a natural product with a stilbene structure, exerts profound proapoptotic activity in human cancer cells, by triggering the accumulation of ceramide, a bioactive sphingolipid. We studied the biological effects of seven methoxylated and/or naphthalene-based resveratrol analogues and compared these compounds with resveratrol with the objective to identify an analogue with higher ceramide-mediated proapoptotic activity relative to resveratrol. Here we show that the compound with three hydroxyls and a naphthalene ring is the most effective in triggering apoptosis coupled to the induction of endogenous ceramide in human cancer cells.
2005
Minutolo, Filippo; G., Sala; A., Bagnacani; Bertini, Simone; I., Carboni; Placanica, Giorgio; G., Prota; Rapposelli, Simona; N., Sacchi; Macchia, Marco; R., Ghidoni
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/181981
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