Resveratrol, a natural product with a stilbene structure, exerts profound proapoptotic activity in human cancer cells, by triggering the accumulation of ceramide, a bioactive sphingolipid. We studied the biological effects of seven methoxylated and/or naphthalene-based resveratrol analogues and compared these compounds with resveratrol with the objective to identify an analogue with higher ceramide-mediated proapoptotic activity relative to resveratrol. Here we show that the compound with three hydroxyls and a naphthalene ring is the most effective in triggering apoptosis coupled to the induction of endogenous ceramide in human cancer cells.
|Autori interni:||MINUTOLO, FILIPPO|
|Autori:||F. MINUTOLO; G. SALA; A. BAGNACANI; S. BERTINI; I. CARBONI; G. PLACANICA; G. PROTA; S. RAPPOSELLI; N. SACCHI; M. MACCHIA; R. GHIDONI|
|Titolo:||Synthesis of a Resveratrol Analogue with High Ceramide-Mediated Proapoptotic Activity on Human Breast Cancer Cells|
|Anno del prodotto:||2005|
|Digital Object Identifier (DOI):||10.1021/jm050528k|
|Appare nelle tipologie:||1.1 Articolo in rivista|