Stable analogues of farnesyl diphosphate, possessing an aniline-type portion in the prenyl-mimic moiety and phosphonoacetamido(oxy) groups in the place of the metabolically unstable diphosphate unit, were synthesised and submitted to biological assays. The enzyme inhibition tests performed on FTase and GGTase I show that the newly synthesised compounds based on a combination of the aniline-containing portions with (phosphonoacetamido)oxy groups do not afford potent inhibitors.
|Autori:||F. MINUTOLO; S. BERTINI; L. BETTI; V. DI BUSSOLO; G. GIANNACCINI; G. PLACANICA; S. RAPPOSELLI; H. P. SPIELMANN; M. MACCHIA|
|Titolo:||Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity|
|Anno del prodotto:||2003|
|Digital Object Identifier (DOI):||10.1016/j.farmac.2003.08.002|
|Appare nelle tipologie:||1.1 Articolo in rivista|