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EnglishTaking as model compound the amido-derivative 1 described in the literature from Duncia's group as a good AngII antagonist, we have synthesized a new series of compounds (2-7) in which the principal structural variations reside in the inversion of the amidic sequence between the two phenyl ring and/or in the type of heteroaromatic substituent linked to this portion. The new compounds synthesized were evaluated for their AT1 affinity through binding assays carried out on rat liver membranes using [125I]Sar1,Ile8-angiotensin II as radioligand
| Autori interni: | |
| Autori: | RAPPOSELLI S; CUBONI S; DIGIACOMO M; LAPUCCI A; TRINCAVELLI M. L; TUCCINARDI T; BALSAMO A |
| Titolo: | Synthesis and AT1 affinity evaluation of benzamidophenyl analogs of known AT1 receptor ligands with similar aromatic skeleton |
| Anno del prodotto: | 2008 |
| Digital Object Identifier (DOI): | 10.3998/ark.5550190.0009.229 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11568/194235
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