Taking as model compound the amido-derivative 1 described in the literature from Duncia's group as a good AngII antagonist, we have synthesized a new series of compounds (2-7) in which the principal structural variations reside in the inversion of the amidic sequence between the two phenyl ring and/or in the type of heteroaromatic substituent linked to this portion. The new compounds synthesized were evaluated for their AT1 affinity through binding assays carried out on rat liver membranes using [125I]Sar1,Ile8-angiotensin II as radioligand
Synthesis and AT1 affinity evaluation of benzamidophenyl analogs of known AT1 receptor ligands with similar aromatic skeleton
RAPPOSELLI, SIMONA;DIGIACOMO, MARIA;LAPUCCI, ANNALINA;TRINCAVELLI, MARIA LETIZIA;TUCCINARDI, TIZIANO;
2008-01-01
Abstract
Taking as model compound the amido-derivative 1 described in the literature from Duncia's group as a good AngII antagonist, we have synthesized a new series of compounds (2-7) in which the principal structural variations reside in the inversion of the amidic sequence between the two phenyl ring and/or in the type of heteroaromatic substituent linked to this portion. The new compounds synthesized were evaluated for their AT1 affinity through binding assays carried out on rat liver membranes using [125I]Sar1,Ile8-angiotensin II as radioligandFile in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
