hLDH5 plays a key role in the glycolytic metabolic switch found in invasive tumours and is now considered as a promising therapeutic target in cancer. Here we report a series of new hLDH5-inhibitors based on triazole-containing N-hydroxyindol-2-carboxylates, whose synthesis includes the highly reliable and simple "click chemistry" reaction.

Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

GRANCHI, CARLOTTA;TUCCINARDI, TIZIANO;BETTI, LAURA;GIANNACCINI, GINO;LUCACCHINI, ANTONIO;MARTINELLI, ADRIANO;MACCHIA, MARCO;MINUTOLO, FILIPPO
2011

Abstract

hLDH5 plays a key role in the glycolytic metabolic switch found in invasive tumours and is now considered as a promising therapeutic target in cancer. Here we report a series of new hLDH5-inhibitors based on triazole-containing N-hydroxyindol-2-carboxylates, whose synthesis includes the highly reliable and simple "click chemistry" reaction.
Granchi, Carlotta; Roy, S; Del Fiandra, C; Tuccinardi, Tiziano; Lanza, M; Betti, Laura; Giannaccini, Gino; Lucacchini, Antonio; Martinelli, Adriano; Macchia, Marco; Minutolo, Filippo
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/189247
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