hLDH5 plays a key role in the glycolytic metabolic switch found in invasive tumours and is now considered as a promising therapeutic target in cancer. Here we report a series of new hLDH5-inhibitors based on triazole-containing N-hydroxyindol-2-carboxylates, whose synthesis includes the highly reliable and simple "click chemistry" reaction.
Autori interni: | |
Autori: | Granchi C; Roy S; Del Fiandra C; Tuccinardi T; Lanza M; Betti L; Giannaccini G; Lucacchini A; Martinelli A; Macchia M; Minutolo F |
Titolo: | Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5) |
Anno del prodotto: | 2011 |
Digital Object Identifier (DOI): | 10.1039/c1md00071c |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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