hLDH5 plays a key role in the glycolytic metabolic switch found in invasive tumours and is now considered as a promising therapeutic target in cancer. Here we report a series of new hLDH5-inhibitors based on triazole-containing N-hydroxyindol-2-carboxylates, whose synthesis includes the highly reliable and simple "click chemistry" reaction.
|Autori:||Granchi C; Roy S; Del Fiandra C; Tuccinardi T; Lanza M; Betti L; Giannaccini G; Lucacchini A; Martinelli A; Macchia M; Minutolo F|
|Titolo:||Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)|
|Anno del prodotto:||2011|
|Digital Object Identifier (DOI):||10.1039/c1md00071c|
|Appare nelle tipologie:||1.1 Articolo in rivista|