Effective glucose diet: We report the development and activity of glucose-conjugated LDH-A inhibitors designed for dual targeting of the Warburg effect (elevated glucose uptake and glycolysis) in cancer cells. Glycoconjugation could be applied to inhibitors of many enzymes involved in glycolysis or tumor metabolism.

Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor

GRANCHI, CARLOTTA;TUCCINARDI, TIZIANO;DI BUSSOLO, VALERIA;MACCHIA, MARCO;MARTINELLI, ADRIANO;MINUTOLO, FILIPPO;
2013

Abstract

Effective glucose diet: We report the development and activity of glucose-conjugated LDH-A inhibitors designed for dual targeting of the Warburg effect (elevated glucose uptake and glycolysis) in cancer cells. Glycoconjugation could be applied to inhibitors of many enzymes involved in glycolysis or tumor metabolism.
Emilia C., Calvaresi; Granchi, Carlotta; Tuccinardi, Tiziano; DI BUSSOLO, Valeria; Robert W., Huigens III; Hyang Yeon, Lee; Rahul, Palchaudhuri; Macchia, Marco; Martinelli, Adriano; Minutolo, Filippo; Paul J., Hergenrother
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/271137
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