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EnglishTwo flavonoids, jaceosidin 7-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside (1) and hispidulin 7-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside (2), and one phenylpropanoid, 3,3'-dimethyl-lunariifolioside (3), along with 11 known compounds (4-14), were isolated from the aerial parts of Phlomis kurdica growing in Jordan. Structures of 1-3 were elucidated on the basis of spectroscopic data. These isolated compounds were assayed for their inhibitory activity against isoform 5 of human lactate dehydrogenase. Compound 4, luteolin 7-O-β-d-glucopyranoside, showed an IC50 value comparable to that of galloflavin, used as reference compound. Docking studies were carried out to hypothesize the interaction mode of compound 4 in the enzyme active site.
| Autori interni: | |
| Autori: | Bader, A; Tuccinardi, T; Granchi, C; Martinelli, A; Macchia, M; Minutolo, F; De Tommasi, N; Braca, A |
| Titolo: | Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase. |
| Anno del prodotto: | 2015 |
| Digital Object Identifier (DOI): | 10.1016/j.phytochem.2015.03.007 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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