DANIELE, SIMONA
 Distribuzione geografica
Continente #
NA - Nord America 12.468
EU - Europa 6.017
AS - Asia 5.795
SA - Sud America 810
AF - Africa 375
OC - Oceania 27
Continente sconosciuto - Info sul continente non disponibili 3
Totale 25.495
Nazione #
US - Stati Uniti d'America 12.081
IT - Italia 2.743
SG - Singapore 1.882
CN - Cina 1.830
HK - Hong Kong 1.032
DE - Germania 711
BR - Brasile 692
SE - Svezia 692
BG - Bulgaria 400
VN - Vietnam 314
CA - Canada 295
GB - Regno Unito 295
AT - Austria 220
RU - Federazione Russa 205
FI - Finlandia 194
TR - Turchia 190
FR - Francia 162
KR - Corea 117
SN - Senegal 111
IN - India 102
NG - Nigeria 101
UA - Ucraina 88
CI - Costa d'Avorio 71
JP - Giappone 61
MX - Messico 58
NL - Olanda 51
PL - Polonia 49
BE - Belgio 42
AR - Argentina 37
ES - Italia 33
BD - Bangladesh 32
IQ - Iraq 30
ID - Indonesia 29
ZA - Sudafrica 28
CH - Svizzera 27
PK - Pakistan 26
AU - Australia 24
GR - Grecia 24
UZ - Uzbekistan 19
CO - Colombia 18
EG - Egitto 18
EC - Ecuador 17
AE - Emirati Arabi Uniti 16
IR - Iran 16
MA - Marocco 16
SA - Arabia Saudita 15
LT - Lituania 14
MY - Malesia 14
VE - Venezuela 13
CZ - Repubblica Ceca 11
UY - Uruguay 11
IE - Irlanda 10
RO - Romania 10
AZ - Azerbaigian 9
IL - Israele 8
JO - Giordania 8
KE - Kenya 7
PE - Perù 7
AL - Albania 6
CL - Cile 6
PY - Paraguay 6
TW - Taiwan 6
CR - Costa Rica 5
HN - Honduras 5
JM - Giamaica 5
NP - Nepal 5
PH - Filippine 5
PT - Portogallo 5
BF - Burkina Faso 4
DK - Danimarca 4
DZ - Algeria 4
GT - Guatemala 4
KZ - Kazakistan 4
NI - Nicaragua 4
BB - Barbados 3
BH - Bahrain 3
DO - Repubblica Dominicana 3
LA - Repubblica Popolare Democratica del Laos 3
MD - Moldavia 3
NZ - Nuova Zelanda 3
TN - Tunisia 3
TT - Trinidad e Tobago 3
A1 - Anonimo 2
BA - Bosnia-Erzegovina 2
BJ - Benin 2
BN - Brunei Darussalam 2
BO - Bolivia 2
BY - Bielorussia 2
EE - Estonia 2
GA - Gabon 2
GE - Georgia 2
HR - Croazia 2
HU - Ungheria 2
KG - Kirghizistan 2
LB - Libano 2
LV - Lettonia 2
MK - Macedonia 2
ML - Mali 2
NO - Norvegia 2
PS - Palestinian Territory 2
Totale 25.474
Città #
Ashburn 1.237
Serra 1.176
Dallas 1.060
Houston 1.036
Hong Kong 1.020
Woodbridge 1.016
Singapore 964
Ann Arbor 857
Fairfield 832
Chandler 725
Santa Clara 594
Shanghai 400
Sofia 399
Seattle 385
Beijing 379
New York 299
Wilmington 298
Cambridge 293
Milan 285
Boardman 267
Ottawa 229
Princeton 207
Vienna 195
Hefei 188
Los Angeles 187
Lawrence 149
Medford 138
Chicago 137
Pisa 122
Frankfurt am Main 116
Des Moines 113
Dakar 111
Nanjing 108
Seoul 102
Florence 98
Lagos 98
London 98
Munich 93
Dearborn 92
Jacksonville 87
Istanbul 85
Izmir 77
Redondo Beach 76
Abidjan 71
Buffalo 71
Lucca 66
Ho Chi Minh City 64
Rome 62
Dong Ket 57
Livorno 57
Council Bluffs 53
Lancaster 47
São Paulo 47
Tokyo 47
Bremen 43
Nanchang 42
Brussels 41
Turku 41
Guangzhou 40
Rho 40
The Dalles 40
Redwood City 39
Warsaw 39
Ogden 38
Alessandria 37
Boulder 36
Columbus 34
San Diego 34
Helsinki 33
Kunming 31
Nuremberg 31
Phoenix 30
Fuzhou 29
Kent 29
Falls Church 28
Hanoi 26
Shenyang 25
Toronto 25
Washington 25
Changsha 23
Bologna 22
Paris 22
San Francisco 22
Montreal 21
Naples 21
Tianjin 21
Hebei 20
Jiaxing 20
Marseille 20
Düsseldorf 19
Rio de Janeiro 19
San Jose 19
Mexico City 18
Auburn Hills 17
Bern 17
Nürnberg 17
Stockholm 17
Atlanta 16
Curitiba 16
Belo Horizonte 15
Totale 18.328
Nome #
Platelet uptake of GABA and glutamate in patients with bipolar disorder. 377
METODO PER LA DIAGNOSI DI MALATTIE NEURODEGENERATIVE 310
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS INHIBITORS OF PDK1 (US Patent App. 15/735,468, 2018) 284
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme 279
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS DUAL INHIBITORS OF PDK1/AURA 275
α-Synuclein Aggregates with β-Amyloid or Tau in Human Red Blood Cells: Correlation with Antioxidant Capability and Physical Exercise in Human Healthy Subjects 274
Antioxidant Capability and Physical Exercise in Neurobiology: A Focus in Neurodegeneration 273
Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma 260
α-Synuclein Aggregated with Tau and β-Amyloid in Human Platelets from Healthy Subjects: Correlation with Physical Exercise 245
Studio sui trasportatori di GABA e glutammato nelle piastrine di soggetti con disturbo bipolare 240
An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds 239
G PROTEIN-COUPLED RECEPTOR DESENSITISATION REGULATES STEM CELL DIFFERENTIATION 233
Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells 233
New insights into the anticancer activity of carnosol: P53 reactivation in the U87MG human glioblastoma cell line 229
An antibody-free strategy for screening putative HDM2 inhibitors using crude bacterial lysates expressing GST-HDM2 recombinant protein 228
Allosteric modulators of human A2B adenosine receptor. 222
Osteogenesis Is Improved by Low Tumor Necrosis Factor Alpha Concentration through the Modulation of Gs-Coupled Receptor Signals 222
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 219
Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma 215
Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells 214
A2A adenosine receptor binding parameters in platelets from patients affected by pathological gambling 211
Protective effect of high-dose montelukast on salbutamol-induced homologous desensitisation in airway smooth muscle. 209
α-Synuclein Heterocomplexes with β-Amyloid Are Increased in Red Blood Cells of Parkinson's Disease Patients and Correlate with Disease Severity 209
Dual inhibition of PDK1 and Aurora Kinase A: an effective strategy to induce differentiation and apoptosis of human glioblastoma multiforme stem cells 207
Memantine prodrug as a new agent for alzheimer’s disease 206
Effect of Ribes nigrum bud extract on human gingival mesenchymal stem cell cytokine release: a role on regenerative processes 201
Carnosol controls the human glioblastoma stemness features through the epithelial-mesenchymal transition modulation and the induction of cancer stem cell apoptosis 201
Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts 197
New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the γ-aminobutyric acid type A (GABAA) receptor 195
Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death 195
Physical Exercise Improves Total Antioxidant Capacity and Gene Expression in Rat Hippocampal Tissue 188
α-Synuclein Heteromers in Red Blood Cells of Alzheimer's Disease and Lewy Body Dementia Patients 184
Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. 183
Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK 183
Epigenetic Modifications of the α-Synuclein Gene and Relative Protein Content Are Affected by Ageing and Physical Exercise in Blood from Healthy Subjects 183
The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization 181
3-(Fur-2-yl)-10-(2-Phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one, a Novel Adenosine Receptor Antagonist with (2A)-Mediated Neuroprotective EffeCTS 178
Prodromal Intestinal Events in Alzheimer's Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition 178
Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells 177
Negative effects of a high tumour necrosis factor-α concentration on human gingival mesenchymal stem cell trophism: The use of natural compounds as modulatory agents 177
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease 176
Adenosine receptors: what we know and what we are learning 175
Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists. 175
The A2B adenosine receptor modulates the epithelial- mesenchymal transition through the balance of cAMP/PKA and MAPK/ERK pathway activation in human epithelial lung cells 175
What Does the Brain Have to Keep Working at Its Best? Resilience Mechanisms Such as Antioxidants and Brain/Cognitive Reserve for Counteracting Alzheimer's Disease Degeneration 174
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A(2B) adenosine receptor antagonists 174
Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor 174
Human Neural Stem Cell Aging Is Counteracted by α-Glycerylphosphorylethanolamine 173
Modulation of A2B Adenosine Receptor by 1-Benzyl-3-ketoindole Derivatives 173
Novel N(2)-Substituted Pyrazolo[3,4-d]pyrimidine Adenosine A(3) Receptor Antagonists: Inhibition of A(3)-Mediated Human Glioblastoma Cell Proliferation (dagger) 172
A new D2 dopamine receptor agonist allosterically modulates A2A adenosine receptor signalling by interacting with the A2A/D2 receptor heteromer 170
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: A Novel Template for the Design of Highly Selective A(2B) Adenosine Receptor Antagonists. 169
Modulation of A2B adenosine receptor by 1-benzyl-3-ketoindole derivatives 169
New Insight into the Central Benzodiazepine Receptor-Ligand Interactions: Design, Synthesis, Biological Evaluation, and Molecular Modeling of 3-Substituted 6-Phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and Related Compounds 169
A mixed-valence diruthenium(ii,iii) complex endowed with high stability: from experimental evidence to theoretical interpretation 168
Apolipoprotein E Polymorphism and Oxidative Stress in Human Peripheral Blood Cells: Can Physical Activity Reactivate the Proteasome System through Epigenetic Mechanisms? 167
Does GRK-β arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways? 166
The oral reversibly-binding antiplatelet agent, Ticagrelor, acts as an antagonist at the P2Y-like receptor GPR17 164
Impact of ApoE Polymorphism and Physical Activity on Plasma Antioxidant Capability and Erythrocyte Membranes 162
Effects of long-term vegan diet on breath composition 161
A1 AND A2B ADENOSINE RECEPTORS REGULATE GLIOBLASTOMA STEM CELL DIFFERENTIATION/SURVIVAL AND SENSITIZE CELLS TO CHEMOTHERAPY 160
Agonist-Induced Desensitization/Resensitization of Human G Protein-Coupled Receptor 17: A Functional Cross-Talk between Purinergic and Cysteinyl-Leukotriene Ligands 159
A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights 155
Endometrial dysbiosis is related to inflammatory factors in women with repeated implantation failure: a pilot study 154
Novel fluorescent triazinobenzimidazole derivatives as probes for labelling human A1 and A2B adenosine receptor subtypes 153
A rapid and efficient immunoenzymatic assay to detect receptor protein interactions: g protein-coupled receptors. 150
Potential biomarkers and novel pharmacological targets in protein aggregation-related neurodegenerative diseases 149
Translocator protein (TSPO) and identification of new molecular diagnosis tools 148
Frontal Affinity Chromatography-Mass Spectrometry Useful for Characterization of New Ligands for GPR17 Receptor 148
The GABAA-BZR Complex as Target for the Development of Anxiolytic Drugs. 148
Modulation of PAR(1) signaling by benzimidazole compounds 148
Long lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells 148
Development of ligands at gamma-aminobutyrric acid type A (GABA(A)) receptor subtype as new agents for pain relief 147
High Levels of β-Amyloid, Tau, and Phospho-Tau in Red Blood Cells as Biomarkers of Neuropathology in Senescence-Accelerated Mouse 145
Modulation of A1 and A2B adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy. 142
Agonist-induced desensitisation/resensitisation of human GPR17: a functional cross talk between purinergic and cysteinyl-leukotriene ligands 141
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas 141
Human gingival mesenchymal stem cell trophism is modulated by inflammatory microenvironment: effects of ribes nigrum bud extract 141
Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation 138
The mesenchymal stem cell differentiation to osteoblasts is potentiate by the allosteric modulation of A2B adenosine receptors. 138
Trazodone regulates neurotrophic/growth factors, mitogen-activated protein kinases and lactate release in human primary astrocytes 137
Exploring Epithelial-Mesenchymal Transition Signals in Endometriosis Diagnosis and In Vitro Fertilization Outcomes 137
A new small molecule, D2 dopamine receptor agonist, as an allosteric modulator of A2A adenosine receptor signalling 135
The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists 134
TUMOR NECROSIS FACTOR ALPHA TRIGGERS OSTEOGENESIS THROUGH THE INVOVLVEMENT OF Gs-COUPLED RECEPTOR SIGNALS 134
Compounds with a benzo [a]carbazole structure for use in the prevention and/or treatment of infectious diseases 133
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. 133
Oxysterols act as promiscuous ligands of class-A GPCRs: In silico molecular modeling and in vitro validation. 132
ROLE OF ADENOSINE RECEPTORS IN SURVIVAL AND DIFFERENTIATION OF GLIOBLASTOMA STEM CELLS 132
A specific combination of nutraceutical Ingredients exerts cytoprotective effects in human cholinergic neurons 131
Allosteric modulation of A2B adenosine receptors potentiate the effects of orthosteric receptor agonists to promote mesenchymal stem cell differentiation to osteoblasts. 131
Discovery of the First-in-Class Dual TSPO/Carbonic Anhydrase Modulators with Promising Neurotrophic Activity 130
In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases 129
COMPOSTI 2-OXO-1,2-DIIDROPIRIDIN-3-CARBOSSAMMIDE E LORO USO COME INIBITORI DI PDK1. 129
Regulation of Erythropoietin Receptor Activity in Endothelial Cells by Different Erythropoietin (EPO) Derivatives: An in Vitro Study. 129
ROLE OF THE P2Y-LIKE RECEPTOR GPR17 IN NEURONAL PRECURSOR CELLS. 128
Aerobic Exercise and Healthy Nutrition as Neuroprotective Agents for Brain Health in Patients with Parkinson's Disease: A Critical Review of the Literature 128
Rational Design and Synthesis of Potent and Selective Adenosine Receptor Antagonists 126
Role of Adenosine Receptors in survival and differentiation of glioblastoma stem cells. 126
Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme 126
Totale 17.893
Categoria #
all - tutte 72.089
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 72.089


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.018 0 0 0 0 0 83 71 146 281 189 61 187
2021/20221.805 40 112 62 83 324 247 73 95 78 65 101 525
2022/20232.739 322 353 187 245 343 330 21 185 525 27 145 56
2023/20241.958 160 152 239 126 262 313 100 74 41 70 114 307
2024/20255.838 64 221 99 349 494 582 482 328 698 776 650 1.095
2025/20264.514 433 1.058 1.029 605 778 611 0 0 0 0 0 0
Totale 26.084