DANIELE, SIMONA
 Distribuzione geografica
Continente #
NA - Nord America 8.386
EU - Europa 4.948
AS - Asia 1.189
AF - Africa 295
OC - Oceania 20
SA - Sud America 12
Continente sconosciuto - Info sul continente non disponibili 3
Totale 14.853
Nazione #
US - Stati Uniti d'America 8.135
IT - Italia 2.457
SE - Svezia 678
CN - Cina 643
DE - Germania 514
BG - Bulgaria 399
CA - Canada 244
GB - Regno Unito 210
AT - Austria 191
VN - Vietnam 164
SG - Singapore 134
FI - Finlandia 115
SN - Senegal 111
FR - Francia 108
NG - Nigeria 98
TR - Turchia 80
CI - Costa d'Avorio 72
UA - Ucraina 72
HK - Hong Kong 63
RU - Federazione Russa 58
IN - India 49
BE - Belgio 33
CH - Svizzera 25
GR - Grecia 22
AU - Australia 19
ES - Italia 17
JP - Giappone 14
KR - Corea 13
NL - Olanda 13
PL - Polonia 12
IR - Iran 8
RO - Romania 7
BR - Brasile 5
MX - Messico 5
EG - Egitto 4
ID - Indonesia 4
IE - Irlanda 4
IL - Israele 4
UZ - Uzbekistan 4
BF - Burkina Faso 3
DK - Danimarca 3
MA - Marocco 3
PT - Portogallo 3
A1 - Anonimo 2
CL - Cile 2
CO - Colombia 2
HR - Croazia 2
PK - Pakistan 2
TW - Taiwan 2
UY - Uruguay 2
ZA - Sudafrica 2
BN - Brunei Darussalam 1
CZ - Repubblica Ceca 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
EE - Estonia 1
EU - Europa 1
JM - Giamaica 1
LA - Repubblica Popolare Democratica del Laos 1
LK - Sri Lanka 1
LT - Lituania 1
MK - Macedonia 1
MY - Malesia 1
NZ - Nuova Zelanda 1
PE - Perù 1
RS - Serbia 1
SA - Arabia Saudita 1
UG - Uganda 1
Totale 14.853
Città #
Serra 1.176
Houston 1.028
Woodbridge 1.016
Ann Arbor 857
Fairfield 832
Chandler 728
Ashburn 451
Sofia 398
Seattle 384
Wilmington 297
Cambridge 293
Milan 263
New York 248
Beijing 244
Ottawa 226
Princeton 207
Vienna 181
Lawrence 149
Medford 137
Des Moines 113
Dakar 111
Nanjing 107
Lagos 98
Dearborn 92
Pisa 89
Jacksonville 86
Florence 81
Izmir 77
London 75
Abidjan 72
Frankfurt am Main 71
Hong Kong 58
Dong Ket 57
Lancaster 47
Lucca 45
Bremen 43
Nanchang 41
Rho 40
Redwood City 39
Livorno 38
Alessandria 37
Boulder 36
Rome 34
Brussels 33
San Diego 33
Guangzhou 32
Kunming 30
Falls Church 28
Los Angeles 26
Washington 24
Hefei 21
Boardman 20
Hebei 20
Jiaxing 20
Marseille 20
Shenyang 20
Auburn Hills 17
Bern 17
Changsha 17
Nürnberg 17
Bologna 15
Jüchen 15
Norwalk 15
Phoenix 15
Tianjin 15
Ogden 14
Cascina 12
Hangzhou 12
San Francisco 12
Bonn 11
Pune 11
Warsaw 11
Detroit 10
Paris 9
San Giuliano Terme 9
Sydney 8
Toronto 8
Carrara 7
Genoa 7
Madrid 7
Massa 7
Pessac 7
Pistoia 7
Genova 6
Helsinki 6
North York 6
Bergamo 5
Capannori 5
Indiana 5
Leawood 5
Orange 5
Palermo 5
Parma 5
Portoferraio 5
Siena 5
Columbus 4
Düsseldorf 4
Fuzhou 4
Jinan 4
Landshut 4
Totale 11.424
Nome #
Platelet uptake of GABA and glutamate in patients with bipolar disorder. 260
Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma 212
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme 209
Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells 179
Allosteric modulators of human A2B adenosine receptor. 177
Osteogenesis Is Improved by Low Tumor Necrosis Factor Alpha Concentration through the Modulation of Gs-Coupled Receptor Signals 177
An antibody-free strategy for screening putative HDM2 inhibitors using crude bacterial lysates expressing GST-HDM2 recombinant protein 174
α-Synuclein Aggregates with β-Amyloid or Tau in Human Red Blood Cells: Correlation with Antioxidant Capability and Physical Exercise in Human Healthy Subjects 174
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 164
Dual inhibition of PDK1 and Aurora Kinase A: an effective strategy to induce differentiation and apoptosis of human glioblastoma multiforme stem cells 162
New insights into the anticancer activity of carnosol: P53 reactivation in the U87MG human glioblastoma cell line 161
Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells 160
New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the γ-aminobutyric acid type A (GABAA) receptor 154
Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma 153
A2A adenosine receptor binding parameters in platelets from patients affected by pathological gambling 151
An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds 151
Studio sui trasportatori di GABA e glutammato nelle piastrine di soggetti con disturbo bipolare 146
METODO PER LA DIAGNOSI DI MALATTIE NEURODEGENERATIVE 146
Protective effect of high-dose montelukast on salbutamol-induced homologous desensitisation in airway smooth muscle. 145
α-Synuclein Heterocomplexes with β-Amyloid Are Increased in Red Blood Cells of Parkinson's Disease Patients and Correlate with Disease Severity 143
α-Synuclein Aggregated with Tau and β-Amyloid in Human Platelets from Healthy Subjects: Correlation with Physical Exercise 141
Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists. 140
Memantine prodrug as a new agent for alzheimer’s disease 140
A new D2 dopamine receptor agonist allosterically modulates A2A adenosine receptor signalling by interacting with the A2A/D2 receptor heteromer 137
Epigenetic Modifications of the α-Synuclein Gene and Relative Protein Content Are Affected by Ageing and Physical Exercise in Blood from Healthy Subjects 135
3-(Fur-2-yl)-10-(2-Phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one, a Novel Adenosine Receptor Antagonist with (2A)-Mediated Neuroprotective EffeCTS 134
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS INHIBITORS OF PDK1 (US Patent App. 15/735,468, 2018) 134
Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor 133
Adenosine receptors: what we know and what we are learning 132
Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK 132
Modulation of A2B Adenosine Receptor by 1-Benzyl-3-ketoindole Derivatives 132
The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization 131
Carnosol controls the human glioblastoma stemness features through the epithelial-mesenchymal transition modulation and the induction of cancer stem cell apoptosis 131
Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death 130
Human Neural Stem Cell Aging Is Counteracted by α-Glycerylphosphorylethanolamine 130
Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. 129
New Insight into the Central Benzodiazepine Receptor-Ligand Interactions: Design, Synthesis, Biological Evaluation, and Molecular Modeling of 3-Substituted 6-Phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and Related Compounds 128
G PROTEIN-COUPLED RECEPTOR DESENSITISATION REGULATES STEM CELL DIFFERENTIATION 127
Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts 127
Modulation of A2B adenosine receptor by 1-benzyl-3-ketoindole derivatives 126
Novel N(2)-Substituted Pyrazolo[3,4-d]pyrimidine Adenosine A(3) Receptor Antagonists: Inhibition of A(3)-Mediated Human Glioblastoma Cell Proliferation (dagger) 125
Effect of Ribes nigrum bud extract on human gingival mesenchymal stem cell cytokine release: a role on regenerative processes 125
null 125
Negative effects of a high tumour necrosis factor-α concentration on human gingival mesenchymal stem cell trophism: The use of natural compounds as modulatory agents 123
Does GRK-β arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways? 120
The oral reversibly-binding antiplatelet agent, Ticagrelor, acts as an antagonist at the P2Y-like receptor GPR17 119
The A2B adenosine receptor modulates the epithelial- mesenchymal transition through the balance of cAMP/PKA and MAPK/ERK pathway activation in human epithelial lung cells 119
Potential biomarkers and novel pharmacological targets in protein aggregation-related neurodegenerative diseases 118
Agonist-Induced Desensitization/Resensitization of Human G Protein-Coupled Receptor 17: A Functional Cross-Talk between Purinergic and Cysteinyl-Leukotriene Ligands 117
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS DUAL INHIBITORS OF PDK1/AURA 117
Physical Exercise Improves Total Antioxidant Capacity and Gene Expression in Rat Hippocampal Tissue 111
Development of ligands at gamma-aminobutyrric acid type A (GABA(A)) receptor subtype as new agents for pain relief 110
Frontal Affinity Chromatography-Mass Spectrometry Useful for Characterization of New Ligands for GPR17 Receptor 110
Modulation of PAR(1) signaling by benzimidazole compounds 109
A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights 109
Translocator protein (TSPO) and identification of new molecular diagnosis tools 107
The GABAA-BZR Complex as Target for the Development of Anxiolytic Drugs. 107
Novel fluorescent triazinobenzimidazole derivatives as probes for labelling human A1 and A2B adenosine receptor subtypes 107
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas 106
null 106
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A(2B) adenosine receptor antagonists 104
Long lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells 104
Agonist-induced desensitisation/resensitisation of human GPR17: a functional cross talk between purinergic and cysteinyl-leukotriene ligands 102
A rapid and efficient immunoenzymatic assay to detect receptor protein interactions: g protein-coupled receptors. 102
COMPOSTI 2-OXO-1,2-DIIDROPIRIDIN-3-CARBOSSAMMIDE E LORO USO COME INIBITORI DI PDK1. 101
A1 AND A2B ADENOSINE RECEPTORS REGULATE GLIOBLASTOMA STEM CELL DIFFERENTIATION/SURVIVAL AND SENSITIZE CELLS TO CHEMOTHERAPY 101
High Levels of β-Amyloid, Tau, and Phospho-Tau in Red Blood Cells as Biomarkers of Neuropathology in Senescence-Accelerated Mouse 101
Rational Design and Synthesis of Potent and Selective Adenosine Receptor Antagonists 99
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: A Novel Template for the Design of Highly Selective A(2B) Adenosine Receptor Antagonists. 98
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease 98
Allosteric modulation of A2B adenosine receptors potentiate the effects of orthosteric receptor agonists to promote mesenchymal stem cell differentiation to osteoblasts. 97
A new small molecule, D2 dopamine receptor agonist, as an allosteric modulator of A2A adenosine receptor signalling 96
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. 96
Impact of ApoE Polymorphism and Physical Activity on Plasma Antioxidant Capability and Erythrocyte Membranes 96
Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation 95
ROLE OF THE P2Y-LIKE RECEPTOR GPR17 IN NEURONAL PRECURSOR CELLS. 94
Human gingival mesenchymal stem cell trophism is modulated by inflammatory microenvironment: effects of ribes nigrum bud extract 94
The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists 92
Regulation of Erythropoietin Receptor Activity in Endothelial Cells by Different Erythropoietin (EPO) Derivatives: An in Vitro Study. 92
Regulation of PC12 cell survival and differentiation by the new P2Y-like receptor GPR17 91
Prodromal Intestinal Events in Alzheimer's Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition 91
Trazodone regulates neurotrophic/growth factors, mitogen-activated protein kinases and lactate release in human primary astrocytes 89
The mesenchymal stem cell differentiation to osteoblasts is potentiate by the allosteric modulation of A2B adenosine receptors. 89
Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPgammaS binding and electrophysiological studies in 1321N1 cells 87
Modulation of A1 and A2B adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy. 86
Brain ageing and neurodegenerative disease: The role of cellular waste management 86
Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme 85
In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases 84
Agonist-induced desensitization of GPR17 in oligodendrocyte precursor cells:a role in the maturation to myelinating cells 84
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 83
A new small molecule, D2 dopamine receptor agonist, as an allosteric modulator of A2A adenosine receptor signalling 82
Glioblastoma multiforme: induction of mitochondria-mediated apoptotic pathway by simultaneous pharmacological activation of TSPO (18KDa) and p53. 82
Receptor crosstalk: haloperidol treatment enhances A(2A) adenosine receptor functioning in a transfected cell model 81
A mixed-valence diruthenium(ii,iii) complex endowed with high stability: from experimental evidence to theoretical interpretation 81
The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. 81
New Fluoro Derivatives of the Pyrazolo[5,1-c][1,2,4]benzotriazine 5-Oxide System: Evaluation of Fluorine Binding Properties in the Benzodiazepine Site on ?-Aminobutyrric Acid Type A (GABA(A)) Receptor. Design, Synthesis, Biological, and Molecular Modeling Investigation 80
D2 dopamine receptor agonists as allosteric modulators of A2A adenosine receptor signalling 80
COMPOSTI 2-OXO-1,2-DIIDROPIRIDIN-3-CARBOSSAMMIDE E LORO USO COME INIBITORI DUALI DI PDK1/AurA” 80
Oxysterols act as promiscuous ligands of class-A GPCRs: In silico molecular modeling and in vitro validation. 79
Role of Adenosine Receptors in survival and differentiation of glioblastoma stem cells. 76
Totale 11.956
Categoria #
all - tutte 37.928
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 37.928


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019484 0 0 0 0 0 0 0 0 0 0 280 204
2019/20203.161 370 187 803 157 199 324 277 189 264 161 188 42
2020/20211.480 163 86 76 45 92 83 71 146 281 189 61 187
2021/20221.805 40 112 62 83 324 247 73 95 78 65 101 525
2022/20232.759 322 355 189 245 344 332 22 187 532 27 147 57
2023/20241.554 160 152 241 126 264 314 103 75 41 71 7 0
Totale 15.348