CINECA IRIS Institutional Research Information System

RAPPOSELLI, SIMONA
 Distribuzione geografica
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Continente #
NA - Nord America 17.274
AS - Asia 7.953
EU - Europa 7.268
SA - Sud America 1.095
Continente sconosciuto - Info sul continente non disponibili 595
AF - Africa 314
OC - Oceania 19
Totale 34.518
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Nazione #
US - Stati Uniti d'America 16.744
IT - Italia 2.634
SG - Singapore 2.503
CN - Cina 2.312
HK - Hong Kong 1.189
SE - Svezia 1.045
DE - Germania 949
BR - Brasile 904
VN - Vietnam 675
BG - Bulgaria 518
FR - Francia 473
CA - Canada 423
TR - Turchia 374
GB - Regno Unito 320
FI - Finlandia 303
RU - Federazione Russa 253
JP - Giappone 186
IN - India 185
AT - Austria 184
UA - Ucraina 162
CI - Costa d'Avorio 96
KR - Corea 95
PL - Polonia 89
BD - Bangladesh 75
CH - Svizzera 73
NL - Olanda 70
AR - Argentina 55
BE - Belgio 46
MX - Messico 46
IQ - Iraq 45
SA - Arabia Saudita 39
SN - Senegal 39
ZA - Sudafrica 38
CZ - Repubblica Ceca 37
ES - Italia 37
ID - Indonesia 35
NG - Nigeria 33
MA - Marocco 31
PK - Pakistan 30
CO - Colombia 28
PH - Filippine 27
VE - Venezuela 26
UZ - Uzbekistan 25
CL - Cile 21
EC - Ecuador 20
MY - Malesia 19
EG - Egitto 18
IL - Israele 18
AU - Australia 17
LT - Lituania 15
JO - Giordania 14
PE - Perù 13
JM - Giamaica 12
PY - Paraguay 12
IR - Iran 11
KE - Kenya 11
NP - Nepal 10
UY - Uruguay 10
AE - Emirati Arabi Uniti 9
CR - Costa Rica 9
DZ - Algeria 9
TN - Tunisia 9
AZ - Azerbaigian 8
KZ - Kazakistan 8
TH - Thailandia 8
TW - Taiwan 8
LB - Libano 7
OM - Oman 7
RO - Romania 7
BJ - Benin 6
IE - Irlanda 6
KH - Cambogia 6
PA - Panama 6
TT - Trinidad e Tobago 6
BB - Barbados 5
DK - Danimarca 5
DO - Repubblica Dominicana 5
GR - Grecia 5
PS - Palestinian Territory 5
PT - Portogallo 5
AL - Albania 4
BO - Bolivia 4
GA - Gabon 4
GE - Georgia 4
GH - Ghana 4
HN - Honduras 4
LK - Sri Lanka 4
NI - Nicaragua 4
NO - Norvegia 4
AO - Angola 3
EE - Estonia 3
EU - Europa 3
GT - Guatemala 3
HU - Ungheria 3
LV - Lettonia 3
MK - Macedonia 3
RS - Serbia 3
A1 - Anonimo 2
BH - Bahrain 2
BW - Botswana 2
Totale 33.887
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Città #
Ashburn 1.853
Woodbridge 1.545
Singapore 1.428
Hong Kong 1.162
Fairfield 1.046
Ann Arbor 964
San Jose 938
Chandler 921
Houston 916
Santa Clara 755
Dallas 745
Serra 675
Shanghai 591
Milan 554
Beijing 532
Sofia 518
Seattle 444
Council Bluffs 373
Wilmington 371
Cambridge 350
New York 342
Ottawa 308
Boardman 293
Los Angeles 270
Princeton 245
Izmir 244
Lawrence 202
Jacksonville 190
Lauterbourg 185
Medford 178
Tokyo 172
Vienna 170
Ho Chi Minh City 159
Pisa 159
Nanjing 154
Des Moines 129
Frankfurt am Main 129
Hefei 123
Hanoi 119
Rome 105
Chicago 100
Abidjan 96
Helsinki 95
Redondo Beach 91
São Paulo 90
Istanbul 89
London 88
Florence 87
Buffalo 80
Dong Ket 79
Munich 79
Seoul 77
Redwood City 76
Marseille 75
Dearborn 74
Warsaw 73
Nanchang 71
San Diego 67
Orem 51
Bern 50
Shenyang 48
The Dalles 46
Boulder 45
Brussels 44
Columbus 43
Dakar 39
Ogden 39
Tianjin 39
Toronto 39
Atlanta 38
Turku 38
Nürnberg 37
Lucca 36
Norwalk 36
Phoenix 36
San Francisco 36
Hebei 35
Da Nang 34
Rio de Janeiro 34
Montreal 32
Lagos 31
Nuremberg 31
Bremen 30
Brno 30
Carrara 30
Hangzhou 28
Livorno 28
Pescara 28
Pune 28
Belo Horizonte 27
Fort Wayne 27
Washington 27
Changsha 26
Kunming 26
Amsterdam 25
Genoa 24
Memphis 24
Auburn Hills 23
Brooklyn 23
Düsseldorf 23
Totale 23.458
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Nome #
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS INHIBITORS OF PDK1 (US Patent App. 15/735,468, 2018) 315
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme 304
Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer 302
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS DUAL INHIBITORS OF PDK1/AURA 302
Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects 301
A patent update on PDK1 inhibitors (2015-present) 286
Synthesis and biological evaluation of (Hetero)aryl-methyloxyphenyl derivatives as potent P-glycoprotein modulating agents. 275
Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease 262
Multifunctional Drugs: New challenging chimeras in medicinal chemistry and drug discovery 244
Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma 240
Synthesis and evaluation of multi-functional NO-donor/insulin-secretagogue derivatives for the treatment of type II diabetes and its cardiovascular complications 239
Dual inhibition of PDK1 and Aurora Kinase A: an effective strategy to induce differentiation and apoptosis of human glioblastoma multiforme stem cells 239
Design, synthesis and biological evaluation of new H2S-releasing rivastigmine derivatives as neuroprotective molecules 233
Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells 232
Memantine prodrug as a new agent for alzheimer’s disease 231
New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design,Synthesis, and Biopharmacological Properties 223
A NEW NITRIC OXIDE RELEASING ANTI-DIABETIC HYBRID DRUG: FROM THE DESIGN TO THE PHARMACOLOGICAL CHARACTERIZATION 218
Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease 215
The pleiotropic functionality of endogenous 3-iodothyronamine (T1AM) and synthetic thyronamine-like analogs: a powerful tool to target interlinked diseases such as obesity and neurodegeneration 215
In-vitro evaluation of new pharmacodynamic hybrids with insulin secretagogue and NO-donor activity 211
Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes 210
Synthesis and AT1 affinity evaluation of benzamidophenyl analogs of known AT1 receptor ligands with similar aromatic skeleton 210
Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition 209
SAR study on arylmethyloxyphenyl scaffold: Looking for a P-gp nanomolar affinity 207
Arylthioamides as H2S Donors:l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo 206
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 205
Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein 205
Enantiopure 3-(arylmethylidene)aminoxy-2-methylpropionic acids: synthesis and antiinflammatory properties 204
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 204
Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands 204
New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2 203
Epibatidine: A Promising Natural Alkaloid in Health 203
Dimer of rivastigmine and caffeic acid or ferulic acid, preparation method and drug composition thereof 202
Oxidative stress, mitochondrial abnormalities and proteins deposition: multitarget approaches in Alzheimer's disease 202
Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer's disease? 202
Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids 201
Endogenous TH metabolite 3-iodothyronamine (T1AM) and synthetic thyronamine-like analogues SG-1 and SG-2 induce autophagy in human glioblastoma cells (U-87MG) 200
Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors 198
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 195
Efficacy of memantine prodrug microemulsion in a Preclinical model of tendinopathy 193
Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells 193
Synthesis and functional evaluation of novel aldose reductase inhibitors bearing a spirobenzopyran scaffold 192
Development of Classification Models for Identifying “True” P-glycoprotein (P-gp) Inhibitors Through Inhibition, ATPase Activation and Monolayer Efflux Assays 192
New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection 192
New monoaryl-salicylaldoximes with improved ERbeta-selective agonist potency 191
Pharmacological study on the cardiovascular activity of no-sartans, pharmacodynamic hybridsexhibiting at1-antagonist and no-donor properties 189
Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase 189
Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents 188
Spirocyclic Benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel 188
Dual PDK1/aurora kinase a inhibitors reduce pancreatic cancer cell proliferation and colony formation 186
Synthesis and 5-HT2A, 5-HT1Aand a1-Binding Affinities of 2-[2- Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-Hydroxy-3-(2- pyridin-2-yl-ethyl)amino]- and 2-[2-Hydroxy-3-(4-N-methylpiperazin- 1-yl)-amino]propoxybenzaldehyde-O-(substituted) Benzyl Oximes 183
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 183
(E)-[2-(4-Methylsulphonylphenyl)-1-cyclopentenyl-1-methyliden]-(arylmethyloxy)amines. Methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: synthesis and biological properties 183
ANTI-ISCHEMIC PROPERTIES OF A NEW SPIRO-CYCLIC BENZOPYRAN ACTIVATOR OF CARDIAC MITOCHONDRIAL ATP-SENSITIVE POTASSIUM CHANNELS 182
Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands 182
Endogenous 3-iodothyronamine (T1Am) and synthetic thyronamine-like analog SG-2 act as novel pleiotropic neuroprotective agents through the modulation of SIRT6 181
New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties 180
Targeting the upregulated PI3K-PDK1-Akt pathway: a drug discovery approach of treating cancer. 178
New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) 177
Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity 177
NO-Sartans: A New Class of Pharmacodynamic Hybrids as Cardiovascular Drugs 176
Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel 176
Mitochondrial Potassium Channels as Pharmacological Target for Cardioprotective Drugs 176
Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis 176
Novel adenosine 5'-triphosphate-sensitive potassium channel ligands: a patent overview (2005 - 2010) 174
H2S-RELEASING PROPERTIES OF NEW THIOAMIDE, IMINOTHIOETHER AND ISOTHIOCYANATE DERIVATIVES 173
A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs 173
Iminothioethers as a novel class of H2S-donor: gasotransmitter release and vascular effects 173
New spiromorpholone- and spiromorpholine-benzopyrane derivatives as potential activators of mito-KATP channel 172
Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells 172
Targeting autophagy impairment improves the phenotype of a novel CLN8 zebrafish model 171
Classification models for the identification of P-gp inhibitors 171
Cardiac ATP-sensitive potassium channels, a potential target for an anti-ischaemic pharmacological strategy 170
Synthesis of a Resveratrol Analogue with High Ceramide-Mediated Proapoptotic Activity on Human Breast Cancer Cells 169
Hydrogen sulfide: A worthwhile tool in the design of new multitarget drugs 169
Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer 165
Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties 164
Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders 164
Ceramide analogues in apoptosis: a new strategy for anticancer drug development 163
SG‐2: A SYNTHETIC ANALOG OF THYROID HORMONE METABOLITE 3‐IODOTHYRONAMINE (T1AM), PREVENTS β‐AMYLOID NEUROTOXICITY IN VITRO 163
Symbiotic approach applied to the synthesis of new agents for the treatment of Alzheimer’s disease 162
Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity 161
Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD 161
Antiarrhythmic activity of a new spiro-cyclic benzopyran activator of the cardiac mitochondrial ATP dependent potassium channels 161
Areca catechu—From farm to food and biomedical applications 160
P-gp Transporter and its Role in Neurodegenerative Diseases 157
Novel Estrogen Receptor Ligands Based on an Anthranylaldoxime Structure: Role of the Phenol-Type Pseudocycle in the Binding Process 156
Aminobenzothiazoles as beta-Selective Estrogen Receptor Ligands 155
Derivati arilpiperazinici quali inibitori della Glicoproteina-P (P-gp) utili nella Multidrug Resistance (MDR) indotta da chemioterapici 154
Synthesis and Biological Evaluation of Cyclopropylamine Vitamin D‐Like CYP24A1 Inhibitors 154
Synthesis and prostaglandin synthase inhibitory activity of new aromatic O-alkyloxime ethers substituted with methylsulfonamido or methylsulfonyl groups on their aliphatic portion 153
Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity 153
Synthesis, Antifungal Activity, and Molecular Modeling Studies of New Inverted Oxime Ethers of Oxiconazole 152
Multi-targeted ChEI-copper chelating molecules as neuroprotective agents 152
NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs 152
THIOAMIDE, IMINOTHIOETHER AND ISOTHIOCYANATE DERIVATIVES: CHEMOTYPES OF SLOW H2S-RELEASING AGENTS 151
Synthesis of new potent P-glycoprotein inhibitors and their screening: potential tools to reduce the multidrug resistance 150
New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective 149
A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions 149
Classification models for the identification of P-gp inhibitors. 148
Totale 19.356
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Categoria #
all - tutte 97.900
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 97.900
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.321 0 185 69 126 379 317 89 127 72 90 142 725
2022/20233.180 382 393 218 260 323 462 19 220 617 35 162 89
2023/20242.483 323 281 277 167 337 387 137 46 29 84 92 323
2024/20256.579 55 311 136 384 553 628 718 357 644 871 695 1.227
2025/20267.800 536 897 780 575 852 730 1.339 344 533 700 370 144
2026/20271.353 265 1.088 0 0 0 0 0 0 0 0 0 0
Totale 34.518