RAPPOSELLI, SIMONA
 Distribuzione geografica
Continente #
NA - Nord America 10.926
EU - Europa 5.788
AS - Asia 2.299
AF - Africa 173
SA - Sud America 23
OC - Oceania 17
Continente sconosciuto - Info sul continente non disponibili 5
Totale 19.231
Nazione #
US - Stati Uniti d'America 10.602
IT - Italia 2.317
CN - Cina 1.011
SE - Svezia 988
DE - Germania 777
SG - Singapore 528
BG - Bulgaria 517
TR - Turchia 334
CA - Canada 322
GB - Regno Unito 214
FR - Francia 197
VN - Vietnam 197
FI - Finlandia 167
AT - Austria 158
UA - Ucraina 149
CI - Costa d'Avorio 94
HK - Hong Kong 79
IN - India 76
RU - Federazione Russa 70
CH - Svizzera 56
BE - Belgio 41
PL - Polonia 41
CZ - Repubblica Ceca 34
SN - Senegal 34
NG - Nigeria 29
NL - Olanda 26
BR - Brasile 17
AU - Australia 16
JP - Giappone 16
KR - Corea 14
ES - Italia 10
IR - Iran 10
IL - Israele 8
BJ - Benin 5
CL - Cile 5
EG - Egitto 5
GR - Grecia 4
ID - Indonesia 4
PK - Pakistan 4
SA - Arabia Saudita 4
UZ - Uzbekistan 4
EU - Europa 3
IE - Irlanda 3
KZ - Kazakistan 3
NO - Norvegia 3
A1 - Anonimo 2
DK - Danimarca 2
HR - Croazia 2
LK - Sri Lanka 2
LT - Lituania 2
MK - Macedonia 2
RO - Romania 2
RS - Serbia 2
TH - Thailandia 2
ZA - Sudafrica 2
BA - Bosnia-Erzegovina 1
BD - Bangladesh 1
CO - Colombia 1
CY - Cipro 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
EE - Estonia 1
GH - Ghana 1
LB - Libano 1
MA - Marocco 1
MD - Moldavia 1
MX - Messico 1
NZ - Nuova Zelanda 1
PT - Portogallo 1
SC - Seychelles 1
Totale 19.231
Città #
Woodbridge 1.545
Fairfield 1.046
Ann Arbor 964
Chandler 921
Houston 899
Serra 675
Ashburn 649
Milan 522
Sofia 517
Seattle 438
Beijing 378
Wilmington 369
Cambridge 349
Ottawa 305
Singapore 303
New York 280
Boardman 270
Princeton 245
Izmir 242
Lawrence 202
Jacksonville 188
Medford 178
Vienna 154
Nanjing 153
Pisa 152
Des Moines 126
Abidjan 94
Frankfurt am Main 84
Istanbul 83
Dong Ket 79
Redwood City 76
Dearborn 74
Hong Kong 74
Marseille 74
Nanchang 71
Chicago 69
Florence 65
Rome 65
London 63
San Diego 60
Dallas 51
Bern 50
Boulder 45
Shenyang 44
Los Angeles 42
Brussels 41
Ogden 40
Nürnberg 37
Norwalk 36
Hebei 35
Warsaw 35
Dakar 34
Carrara 32
Bremen 30
Brno 30
Santa Clara 30
Lagos 29
Pescara 27
Shanghai 26
Hangzhou 25
Kunming 25
Pune 25
Livorno 24
Washington 24
Auburn Hills 23
Changsha 23
Fuzhou 23
Jüchen 23
Pessac 21
Tianjin 18
Genoa 17
San Francisco 16
Wuhan 15
Middleton 14
Orange 14
Lancaster 13
Phoenix 13
Enterprise 12
Fort Wayne 12
Jiaxing 12
Lucca 12
Naples 12
Toronto 12
Fiumicino 11
Hyderabad 11
Jinan 11
Hefei 10
Helsinki 10
Eindhoven 9
Paris 9
Quanzhou 9
Tokyo 9
Cascina 8
Guangzhou 8
Lacchiarella 8
Indiana 7
Munich 7
San Giuliano Terme 7
Siena 7
Belo Horizonte 6
Totale 14.370
Nome #
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme 217
Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer 213
Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects 180
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS INHIBITORS OF PDK1 (US Patent App. 15/735,468, 2018) 169
Dual inhibition of PDK1 and Aurora Kinase A: an effective strategy to induce differentiation and apoptosis of human glioblastoma multiforme stem cells 167
A NEW NITRIC OXIDE RELEASING ANTI-DIABETIC HYBRID DRUG: FROM THE DESIGN TO THE PHARMACOLOGICAL CHARACTERIZATION 165
Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells 165
A patent update on PDK1 inhibitors (2015-present) 164
New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design,Synthesis, and Biopharmacological Properties 162
Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma 159
Arylthioamides as H2S Donors:l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo 154
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS DUAL INHIBITORS OF PDK1/AURA 152
Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease 151
Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes 151
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 147
Synthesis and evaluation of multi-functional NO-donor/insulin-secretagogue derivatives for the treatment of type II diabetes and its cardiovascular complications 146
Enantiopure 3-(arylmethylidene)aminoxy-2-methylpropionic acids: synthesis and antiinflammatory properties 145
Memantine prodrug as a new agent for alzheimer’s disease 145
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 143
Synthesis and AT1 affinity evaluation of benzamidophenyl analogs of known AT1 receptor ligands with similar aromatic skeleton 142
Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors 140
ANTI-ISCHEMIC PROPERTIES OF A NEW SPIRO-CYCLIC BENZOPYRAN ACTIVATOR OF CARDIAC MITOCHONDRIAL ATP-SENSITIVE POTASSIUM CHANNELS 139
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 137
Mitochondrial Potassium Channels as Pharmacological Target for Cardioprotective Drugs 136
In-vitro evaluation of new pharmacodynamic hybrids with insulin secretagogue and NO-donor activity 135
Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel 135
Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells 133
NO-Sartans: A New Class of Pharmacodynamic Hybrids as Cardiovascular Drugs 133
Dimer of rivastigmine and caffeic acid or ferulic acid, preparation method and drug composition thereof 133
Pharmacological study on the cardiovascular activity of no-sartans, pharmacodynamic hybridsexhibiting at1-antagonist and no-donor properties 132
Antiarrhythmic activity of a new spiro-cyclic benzopyran activator of the cardiac mitochondrial ATP dependent potassium channels 132
null 132
Synthesis and 5-HT2A, 5-HT1Aand a1-Binding Affinities of 2-[2- Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-Hydroxy-3-(2- pyridin-2-yl-ethyl)amino]- and 2-[2-Hydroxy-3-(4-N-methylpiperazin- 1-yl)-amino]propoxybenzaldehyde-O-(substituted) Benzyl Oximes 131
New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection 130
Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition 126
(E)-[2-(4-Methylsulphonylphenyl)-1-cyclopentenyl-1-methyliden]-(arylmethyloxy)amines. Methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: synthesis and biological properties 126
Synthesis and functional evaluation of novel aldose reductase inhibitors bearing a spirobenzopyran scaffold 126
Endogenous TH metabolite 3-iodothyronamine (T1AM) and synthetic thyronamine-like analogues SG-1 and SG-2 induce autophagy in human glioblastoma cells (U-87MG) 126
Novel adenosine 5'-triphosphate-sensitive potassium channel ligands: a patent overview (2005 - 2010) 124
Ceramide analogues in apoptosis: a new strategy for anticancer drug development 124
New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) 124
New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties 123
Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein 123
A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs 120
SAR study on arylmethyloxyphenyl scaffold: Looking for a P-gp nanomolar affinity 120
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 120
Development of Classification Models for Identifying “True” P-glycoprotein (P-gp) Inhibitors Through Inhibition, ATPase Activation and Monolayer Efflux Assays 120
Spirocyclic Benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel 120
Cardiac ATP-sensitive potassium channels, a potential target for an anti-ischaemic pharmacological strategy 118
Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands 117
Synthesis of a Resveratrol Analogue with High Ceramide-Mediated Proapoptotic Activity on Human Breast Cancer Cells 117
P-gp Transporter and its Role in Neurodegenerative Diseases 117
New spiromorpholone- and spiromorpholine-benzopyrane derivatives as potential activators of mito-KATP channel 116
Derivati arilpiperazinici quali inibitori della Glicoproteina-P (P-gp) utili nella Multidrug Resistance (MDR) indotta da chemioterapici 116
H2S-RELEASING PROPERTIES OF NEW THIOAMIDE, IMINOTHIOETHER AND ISOTHIOCYANATE DERIVATIVES 116
Oxidative stress, mitochondrial abnormalities and proteins deposition: multitarget approaches in Alzheimer's disease 114
Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease 114
null 114
Evaluation of the NO-releasing properties of NO-donor linkers 113
Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents 113
The pleiotropic functionality of endogenous 3-iodothyronamine (T1AM) and synthetic thyronamine-like analogs: a powerful tool to target interlinked diseases such as obesity and neurodegeneration 113
Synthesis and prostaglandin synthase inhibitory activity of new aromatic O-alkyloxime ethers substituted with methylsulfonamido or methylsulfonyl groups on their aliphatic portion 111
Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase 111
Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity 111
Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer's disease? 109
Epibatidine: A Promising Natural Alkaloid in Health 108
Aminobenzothiazoles as beta-Selective Estrogen Receptor Ligands 106
Targeting the upregulated PI3K-PDK1-Akt pathway: a drug discovery approach of treating cancer. 106
COMPOSTI 2-OXO-1,2-DIIDROPIRIDIN-3-CARBOSSAMMIDE E LORO USO COME INIBITORI DI PDK1. 106
Synthesis, Antifungal Activity, and Molecular Modeling Studies of New Inverted Oxime Ethers of Oxiconazole 105
Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity 105
Hydrogen sulfide: A worthwhile tool in the design of new multitarget drugs 105
NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs 105
alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors 104
Dual PDK1/aurora kinase a inhibitors reduce pancreatic cancer cell proliferation and colony formation 104
THIOAMIDE, IMINOTHIOETHER AND ISOTHIOCYANATE DERIVATIVES: CHEMOTYPES OF SLOW H2S-RELEASING AGENTS 103
Synthesis and Affinity Evaluation for AT1 Receptor of Phenylsalicylaldoxime-Derivatives Structurally Related to Sartans 103
Synthesis and COX2 inhibitory properties of N-Phenyl-and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene, and isoxazole analogs 103
1-Phenylalkoxy-2-β-phenylethyl derivatives as P-glycoprotein (P-GP) inhibitors useful in drug resistance events 103
Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity 102
Classification models for the identification of P-gp inhibitors 101
Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties 101
Synthesis of new potent P-glycoprotein inhibitors and their screening: potential tools to reduce the multidrug resistance 100
Synthesis and Biological Evaluation of (Hetero)Arylmethyloxy- and Arylmethylamine-phenyl Derivatives as Potent P-glycoprotein Modulating Agents 100
Novel Estrogen Receptor Ligands Based on an Anthranylaldoxime Structure: Role of the Phenol-Type Pseudocycle in the Binding Process 99
A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions 97
NO-Releasing Hybrids of Cardiovascular Drugs 96
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW 7BETA-(BENZO[A]DIHYDROCARBAZOLYLOXYACETYL)-SUBSTITUTED CEPHALOSPORINS 96
Synthesis and Biological Evaluation of Cyclopropylamine Vitamin D‐Like CYP24A1 Inhibitors 96
Proposal of a new binding orientation for non-peptide AT1 antagonists: Homology modeling, docking and three-dimensional quantitative structure-activity relationship analysis 95
Symbiotic approach applied to the synthesis of new agents for the treatment of Alzheimer’s disease 95
Endogenous 3-iodothyronamine (T1Am) and synthetic thyronamine-like analog SG-2 act as novel pleiotropic neuroprotective agents through the modulation of SIRT6 94
In-vitro evaluation of new pharmacodynamic hybrids with insulin secretagogue and NO-donor activity 93
Classification models for the identification of P-gp inhibitors. 93
Derivati 2,2-dimetilcromanici 4-spiro-eterociclici azotati (a 5 e 6 termini) N-sostituiti quali cardio-protettori nei confronti dell''insulto ischemico 92
NO-releasing hybrids of cardiovascular drugs 92
Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase 91
Enantioselectivity in Cardioprotection induced by (S)- (-)-2,2-Dimethyl-N-(4'-acetamido-benzyl)-4-spiromorpholone-chromane 91
A novel approach in glioblastoma multiforme drug discovery: Perturbation studies in vitro 91
Multi-targeted ChEI-copper chelating molecules as neuroprotective agents 91
Totale 12.249
Categoria #
all - tutte 54.456
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 54.456


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.047 0 0 0 0 253 329 331 235 279 276 259 85
2020/20211.678 117 94 86 80 159 126 150 145 247 120 94 260
2021/20222.354 33 185 69 126 379 317 89 127 72 90 142 725
2022/20233.180 382 393 218 260 323 462 19 220 617 35 162 89
2023/20242.499 327 283 278 172 337 388 137 46 29 84 93 325
2024/2025945 55 312 136 387 55 0 0 0 0 0 0 0
Totale 19.747