CINECA IRIS Institutional Research Information System

RAPPOSELLI, SIMONA
 Distribuzione geografica
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Continente #
NA - Nord America 20.274
AS - Asia 7.985
EU - Europa 7.439
SA - Sud America 1.130
Continente sconosciuto - Info sul continente non disponibili 599
AF - Africa 325
OC - Oceania 19
Totale 37.771
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Nazione #
US - Stati Uniti d'America 19.560
IT - Italia 2.727
SG - Singapore 2.504
CN - Cina 2.316
HK - Hong Kong 1.189
SE - Svezia 1.050
DE - Germania 953
BR - Brasile 927
VN - Vietnam 675
CA - Canada 548
BG - Bulgaria 518
FR - Francia 477
TR - Turchia 374
GB - Regno Unito 342
FI - Finlandia 303
RU - Federazione Russa 279
JP - Giappone 188
IN - India 186
AT - Austria 184
UA - Ucraina 163
CI - Costa d'Avorio 97
KR - Corea 96
PL - Polonia 91
BD - Bangladesh 77
CH - Svizzera 73
NL - Olanda 72
AR - Argentina 55
BE - Belgio 46
MX - Messico 46
IQ - Iraq 45
ES - Italia 41
SA - Arabia Saudita 39
SN - Senegal 39
ZA - Sudafrica 39
CZ - Repubblica Ceca 37
ID - Indonesia 37
NG - Nigeria 33
CO - Colombia 32
PK - Pakistan 32
IL - Israele 31
MA - Marocco 31
VE - Venezuela 31
PH - Filippine 27
JM - Giamaica 25
UZ - Uzbekistan 25
CL - Cile 22
EC - Ecuador 22
MY - Malesia 22
CR - Costa Rica 21
EG - Egitto 18
AU - Australia 17
LT - Lituania 17
JO - Giordania 14
PE - Perù 13
PY - Paraguay 12
TT - Trinidad e Tobago 12
IR - Iran 11
KE - Kenya 11
NP - Nepal 10
UY - Uruguay 10
AE - Emirati Arabi Uniti 9
DZ - Algeria 9
HN - Honduras 9
TN - Tunisia 9
AZ - Azerbaigian 8
KZ - Kazakistan 8
SC - Seychelles 8
TH - Thailandia 8
TW - Taiwan 8
BB - Barbados 7
DK - Danimarca 7
EE - Estonia 7
LB - Libano 7
NI - Nicaragua 7
OM - Oman 7
PR - Porto Rico 7
RO - Romania 7
BJ - Benin 6
IE - Irlanda 6
KH - Cambogia 6
PA - Panama 6
DO - Repubblica Dominicana 5
GR - Grecia 5
GT - Guatemala 5
PS - Palestinian Territory 5
PT - Portogallo 5
SV - El Salvador 5
AL - Albania 4
BO - Bolivia 4
GA - Gabon 4
GE - Georgia 4
GH - Ghana 4
LK - Sri Lanka 4
NO - Norvegia 4
AO - Angola 3
CW - ???statistics.table.value.countryCode.CW??? 3
EU - Europa 3
HU - Ungheria 3
LV - Lettonia 3
MK - Macedonia 3
Totale 37.124
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Città #
Ashburn 2.473
Woodbridge 1.545
Singapore 1.428
Hong Kong 1.162
San Jose 1.145
Fairfield 1.046
Ann Arbor 964
Houston 923
Chandler 922
Santa Clara 768
Dallas 756
Serra 675
Shanghai 591
Milan 560
Beijing 532
Sofia 518
Council Bluffs 511
Seattle 449
Wilmington 372
New York 358
Cambridge 350
Ottawa 313
Boardman 306
Los Angeles 294
Princeton 287
Izmir 244
Lawrence 204
Jacksonville 193
Lauterbourg 185
Medford 178
Tokyo 174
Vienna 171
Pisa 170
Ho Chi Minh City 159
Nanjing 154
Des Moines 130
Frankfurt am Main 130
Hefei 123
Hanoi 119
Rome 112
Chicago 110
São Paulo 104
Abidjan 97
Helsinki 95
Florence 92
Redondo Beach 91
London 90
Istanbul 89
Buffalo 84
Dong Ket 79
Munich 79
Seoul 78
Redwood City 76
Dearborn 75
Marseille 75
Warsaw 73
Nanchang 71
San Diego 70
Atlanta 53
Toronto 52
Orem 51
Bern 50
Columbus 49
Shenyang 48
The Dalles 48
Boulder 45
Phoenix 45
Brussels 44
Montreal 42
San Francisco 42
Dakar 39
Ogden 39
Tianjin 39
Norwalk 38
Turku 38
Nürnberg 37
Brooklyn 36
Lucca 36
Hebei 35
Da Nang 34
Rio de Janeiro 34
Nuremberg 32
Lagos 31
Washington 31
Bremen 30
Brno 30
Carrara 30
Fort Wayne 29
Belo Horizonte 28
Genoa 28
Hangzhou 28
Livorno 28
Pescara 28
Pune 28
Abbeville 27
Denver 27
Amsterdam 26
Changsha 26
Kunming 26
Memphis 25
Totale 24.734
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Nome #
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS INHIBITORS OF PDK1 (US Patent App. 15/735,468, 2018) 348
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS DUAL INHIBITORS OF PDK1/AURA 320
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme 318
Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects 318
Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer 312
A patent update on PDK1 inhibitors (2015-present) 298
Synthesis and biological evaluation of (Hetero)aryl-methyloxyphenyl derivatives as potent P-glycoprotein modulating agents. 286
Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease 283
Design, synthesis and biological evaluation of new H2S-releasing rivastigmine derivatives as neuroprotective molecules 263
Dual inhibition of PDK1 and Aurora Kinase A: an effective strategy to induce differentiation and apoptosis of human glioblastoma multiforme stem cells 263
Synthesis and evaluation of multi-functional NO-donor/insulin-secretagogue derivatives for the treatment of type II diabetes and its cardiovascular complications 253
Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma 253
Multifunctional Drugs: New challenging chimeras in medicinal chemistry and drug discovery 252
Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells 251
Memantine prodrug as a new agent for alzheimer’s disease 246
A NEW NITRIC OXIDE RELEASING ANTI-DIABETIC HYBRID DRUG: FROM THE DESIGN TO THE PHARMACOLOGICAL CHARACTERIZATION 245
New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design,Synthesis, and Biopharmacological Properties 236
In-vitro evaluation of new pharmacodynamic hybrids with insulin secretagogue and NO-donor activity 230
The pleiotropic functionality of endogenous 3-iodothyronamine (T1AM) and synthetic thyronamine-like analogs: a powerful tool to target interlinked diseases such as obesity and neurodegeneration 228
Synthesis and AT1 affinity evaluation of benzamidophenyl analogs of known AT1 receptor ligands with similar aromatic skeleton 226
Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes 225
SAR study on arylmethyloxyphenyl scaffold: Looking for a P-gp nanomolar affinity 225
Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands 225
Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease 223
Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition 222
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 221
Arylthioamides as H2S Donors:l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo 221
Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein 221
New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2 220
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 219
Epibatidine: A Promising Natural Alkaloid in Health 217
Oxidative stress, mitochondrial abnormalities and proteins deposition: multitarget approaches in Alzheimer's disease 216
Efficacy of memantine prodrug microemulsion in a Preclinical model of tendinopathy 215
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 215
Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer's disease? 215
Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids 215
Enantiopure 3-(arylmethylidene)aminoxy-2-methylpropionic acids: synthesis and antiinflammatory properties 213
Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors 213
Dimer of rivastigmine and caffeic acid or ferulic acid, preparation method and drug composition thereof 212
Endogenous TH metabolite 3-iodothyronamine (T1AM) and synthetic thyronamine-like analogues SG-1 and SG-2 induce autophagy in human glioblastoma cells (U-87MG) 211
Pharmacological study on the cardiovascular activity of no-sartans, pharmacodynamic hybridsexhibiting at1-antagonist and no-donor properties 210
Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells 208
Synthesis and functional evaluation of novel aldose reductase inhibitors bearing a spirobenzopyran scaffold 205
New monoaryl-salicylaldoximes with improved ERbeta-selective agonist potency 204
Development of Classification Models for Identifying “True” P-glycoprotein (P-gp) Inhibitors Through Inhibition, ATPase Activation and Monolayer Efflux Assays 204
New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection 204
ANTI-ISCHEMIC PROPERTIES OF A NEW SPIRO-CYCLIC BENZOPYRAN ACTIVATOR OF CARDIAC MITOCHONDRIAL ATP-SENSITIVE POTASSIUM CHANNELS 202
Dual PDK1/aurora kinase a inhibitors reduce pancreatic cancer cell proliferation and colony formation 199
Targeting autophagy impairment improves the phenotype of a novel CLN8 zebrafish model 198
Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents 198
Spirocyclic Benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel 198
NO-Sartans: A New Class of Pharmacodynamic Hybrids as Cardiovascular Drugs 197
Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase 197
Synthesis and 5-HT2A, 5-HT1Aand a1-Binding Affinities of 2-[2- Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-Hydroxy-3-(2- pyridin-2-yl-ethyl)amino]- and 2-[2-Hydroxy-3-(4-N-methylpiperazin- 1-yl)-amino]propoxybenzaldehyde-O-(substituted) Benzyl Oximes 196
Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands 196
New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) 195
(E)-[2-(4-Methylsulphonylphenyl)-1-cyclopentenyl-1-methyliden]-(arylmethyloxy)amines. Methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: synthesis and biological properties 195
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 194
Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis 193
Endogenous 3-iodothyronamine (T1Am) and synthetic thyronamine-like analog SG-2 act as novel pleiotropic neuroprotective agents through the modulation of SIRT6 191
Targeting the upregulated PI3K-PDK1-Akt pathway: a drug discovery approach of treating cancer. 190
New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties 189
Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel 189
Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity 189
Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders 188
New spiromorpholone- and spiromorpholine-benzopyrane derivatives as potential activators of mito-KATP channel 187
Mitochondrial Potassium Channels as Pharmacological Target for Cardioprotective Drugs 186
Iminothioethers as a novel class of H2S-donor: gasotransmitter release and vascular effects 186
Novel adenosine 5'-triphosphate-sensitive potassium channel ligands: a patent overview (2005 - 2010) 185
Cardiac ATP-sensitive potassium channels, a potential target for an anti-ischaemic pharmacological strategy 184
Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity 184
H2S-RELEASING PROPERTIES OF NEW THIOAMIDE, IMINOTHIOETHER AND ISOTHIOCYANATE DERIVATIVES 183
Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells 183
A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs 183
Symbiotic approach applied to the synthesis of new agents for the treatment of Alzheimer’s disease 182
Classification models for the identification of P-gp inhibitors 180
Synthesis of a Resveratrol Analogue with High Ceramide-Mediated Proapoptotic Activity on Human Breast Cancer Cells 180
Hydrogen sulfide: A worthwhile tool in the design of new multitarget drugs 180
Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties 179
Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer 179
1-Phenylalkoxy-2-β-phenylethyl derivatives as P-glycoprotein (P-GP) inhibitors useful in drug resistance events 177
SG‐2: A SYNTHETIC ANALOG OF THYROID HORMONE METABOLITE 3‐IODOTHYRONAMINE (T1AM), PREVENTS β‐AMYLOID NEUROTOXICITY IN VITRO 177
Aminobenzothiazoles as beta-Selective Estrogen Receptor Ligands 176
Ceramide analogues in apoptosis: a new strategy for anticancer drug development 174
New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective 174
Derivati arilpiperazinici quali inibitori della Glicoproteina-P (P-gp) utili nella Multidrug Resistance (MDR) indotta da chemioterapici 172
Areca catechu—From farm to food and biomedical applications 172
THIOAMIDE, IMINOTHIOETHER AND ISOTHIOCYANATE DERIVATIVES: CHEMOTYPES OF SLOW H2S-RELEASING AGENTS 170
P-gp Transporter and its Role in Neurodegenerative Diseases 170
Antiarrhythmic activity of a new spiro-cyclic benzopyran activator of the cardiac mitochondrial ATP dependent potassium channels 169
Synthesis, Antifungal Activity, and Molecular Modeling Studies of New Inverted Oxime Ethers of Oxiconazole 168
Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD 168
Classification models for the identification of P-gp inhibitors. 167
Novel Estrogen Receptor Ligands Based on an Anthranylaldoxime Structure: Role of the Phenol-Type Pseudocycle in the Binding Process 167
Synthesis and Biological Evaluation of Cyclopropylamine Vitamin D‐Like CYP24A1 Inhibitors 167
Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity 165
Pharmacodynamic hybrids with insulin secretagogue and NO-Donor activity 164
Evaluation of the NO-releasing properties of NO-donor linkers 163
Multi-targeted ChEI-copper chelating molecules as neuroprotective agents 163
SUN-717 SG-2 a Novel Multi-Target Directed Ligand (MTDL) for the Treatment of Neurodegenerative Diseases (NDDS) 163
Totale 20.849
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Categoria #
all - tutte 105.345
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 105.345
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.941 0 0 0 0 379 317 89 127 72 90 142 725
2022/20233.180 382 393 218 260 323 462 19 220 617 35 162 89
2023/20242.483 323 281 277 167 337 387 137 46 29 84 92 323
2024/20256.579 55 311 136 384 553 628 718 357 644 871 695 1.227
2025/20267.800 536 897 780 575 852 730 1.339 344 533 700 370 144
2026/20274.606 265 1.120 1.612 1.327 282 0 0 0 0 0 0 0
Totale 37.771