CINECA IRIS Institutional Research Information System

RAPPOSELLI, SIMONA
 Distribuzione geografica
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Continente #
NA - Nord America 14.266
EU - Europa 6.607
AS - Asia 5.867
SA - Sud America 925
AF - Africa 263
OC - Oceania 19
Continente sconosciuto - Info sul continente non disponibili 5
Totale 27.952
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Nazione #
US - Stati Uniti d'America 13.837
IT - Italia 2.462
CN - Cina 2.099
SG - Singapore 1.385
HK - Hong Kong 1.129
SE - Svezia 1.001
DE - Germania 919
BR - Brasile 803
BG - Bulgaria 518
CA - Canada 364
TR - Turchia 363
VN - Vietnam 309
GB - Regno Unito 280
FR - Francia 263
RU - Federazione Russa 245
FI - Finlandia 223
AT - Austria 180
UA - Ucraina 158
IN - India 130
CI - Costa d'Avorio 96
KR - Corea 93
PL - Polonia 76
JP - Giappone 68
CH - Svizzera 57
NL - Olanda 55
BE - Belgio 45
BD - Bangladesh 44
SN - Senegal 38
CZ - Repubblica Ceca 37
AR - Argentina 34
MX - Messico 31
NG - Nigeria 31
SA - Arabia Saudita 29
ZA - Sudafrica 29
ID - Indonesia 28
IQ - Iraq 28
ES - Italia 25
MA - Marocco 22
PK - Pakistan 20
EC - Ecuador 18
AU - Australia 17
PH - Filippine 16
CO - Colombia 15
UZ - Uzbekistan 15
LT - Lituania 14
VE - Venezuela 14
EG - Egitto 13
IL - Israele 13
IR - Iran 11
CL - Cile 10
PE - Perù 10
JO - Giordania 9
MY - Malesia 9
PY - Paraguay 9
KZ - Kazakistan 8
UY - Uruguay 8
AE - Emirati Arabi Uniti 7
JM - Giamaica 7
LB - Libano 7
AZ - Azerbaigian 6
IE - Irlanda 6
NP - Nepal 6
PA - Panama 6
TW - Taiwan 6
BJ - Benin 5
CR - Costa Rica 5
DO - Repubblica Dominicana 5
GR - Grecia 5
OM - Oman 5
TH - Thailandia 5
TN - Tunisia 5
AL - Albania 4
DZ - Algeria 4
GA - Gabon 4
KE - Kenya 4
PS - Palestinian Territory 4
PT - Portogallo 4
BB - Barbados 3
BO - Bolivia 3
EE - Estonia 3
EU - Europa 3
GH - Ghana 3
KH - Cambogia 3
LK - Sri Lanka 3
LV - Lettonia 3
NO - Norvegia 3
RO - Romania 3
RS - Serbia 3
TT - Trinidad e Tobago 3
A1 - Anonimo 2
AO - Angola 2
DK - Danimarca 2
GE - Georgia 2
HN - Honduras 2
HR - Croazia 2
HU - Ungheria 2
LU - Lussemburgo 2
MK - Macedonia 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
Totale 27.931
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Città #
Woodbridge 1.545
Ashburn 1.536
Hong Kong 1.120
Fairfield 1.046
Ann Arbor 964
Chandler 921
Houston 905
Singapore 724
Santa Clara 723
Dallas 718
Serra 675
Shanghai 585
Milan 533
Sofia 518
Beijing 502
Seattle 441
Wilmington 370
Cambridge 349
New York 311
Ottawa 306
Boardman 270
Princeton 245
Izmir 244
Los Angeles 214
Lawrence 202
Jacksonville 188
Medford 178
Vienna 168
Pisa 156
Nanjing 153
Des Moines 126
Hefei 123
Frankfurt am Main 114
Abidjan 96
Chicago 91
Redondo Beach 91
Istanbul 88
Rome 88
London 81
Dong Ket 79
Florence 76
Redwood City 76
Seoul 76
Dearborn 74
Marseille 74
Munich 74
Nanchang 71
Buffalo 65
Warsaw 65
São Paulo 62
San Diego 60
Tokyo 57
Council Bluffs 52
Bern 50
Shenyang 47
Boulder 45
Brussels 44
The Dalles 43
Ho Chi Minh City 40
Ogden 39
Dakar 38
Turku 38
Nürnberg 37
Columbus 36
Norwalk 36
Hebei 35
Lucca 34
Rio de Janeiro 34
Lagos 31
Bremen 30
Brno 30
Carrara 30
San Francisco 30
Hanoi 29
Livorno 28
Hangzhou 27
Pescara 27
Pune 27
Belo Horizonte 26
Changsha 26
Fort Wayne 26
Kunming 26
Nuremberg 25
Phoenix 25
Washington 25
Toronto 24
Auburn Hills 23
Düsseldorf 23
Fuzhou 23
Jüchen 23
Genoa 22
Helsinki 21
Pessac 21
Tianjin 20
Wuhan 20
Brasília 18
Brooklyn 18
Amsterdam 17
Boston 17
Johannesburg 17
Totale 20.040
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Nome #
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS INHIBITORS OF PDK1 (US Patent App. 15/735,468, 2018) 276
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme 275
Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer 270
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS DUAL INHIBITORS OF PDK1/AURA 268
A patent update on PDK1 inhibitors (2015-present) 256
Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects 243
Multifunctional Drugs: New challenging chimeras in medicinal chemistry and drug discovery 230
Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma 209
Synthesis and evaluation of multi-functional NO-donor/insulin-secretagogue derivatives for the treatment of type II diabetes and its cardiovascular complications 208
Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells 208
New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design,Synthesis, and Biopharmacological Properties 204
Dual inhibition of PDK1 and Aurora Kinase A: an effective strategy to induce differentiation and apoptosis of human glioblastoma multiforme stem cells 201
A NEW NITRIC OXIDE RELEASING ANTI-DIABETIC HYBRID DRUG: FROM THE DESIGN TO THE PHARMACOLOGICAL CHARACTERIZATION 197
Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease 197
Memantine prodrug as a new agent for alzheimer’s disease 195
Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes 190
Synthesis and AT1 affinity evaluation of benzamidophenyl analogs of known AT1 receptor ligands with similar aromatic skeleton 190
Enantiopure 3-(arylmethylidene)aminoxy-2-methylpropionic acids: synthesis and antiinflammatory properties 187
Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease 187
Arylthioamides as H2S Donors:l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo 186
Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein 185
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 184
SAR study on arylmethyloxyphenyl scaffold: Looking for a P-gp nanomolar affinity 182
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 180
In-vitro evaluation of new pharmacodynamic hybrids with insulin secretagogue and NO-donor activity 175
Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors 175
Dimer of rivastigmine and caffeic acid or ferulic acid, preparation method and drug composition thereof 174
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 174
The pleiotropic functionality of endogenous 3-iodothyronamine (T1AM) and synthetic thyronamine-like analogs: a powerful tool to target interlinked diseases such as obesity and neurodegeneration 174
Endogenous TH metabolite 3-iodothyronamine (T1AM) and synthetic thyronamine-like analogues SG-1 and SG-2 induce autophagy in human glioblastoma cells (U-87MG) 173
Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition 171
Synthesis and 5-HT2A, 5-HT1Aand a1-Binding Affinities of 2-[2- Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-Hydroxy-3-(2- pyridin-2-yl-ethyl)amino]- and 2-[2-Hydroxy-3-(4-N-methylpiperazin- 1-yl)-amino]propoxybenzaldehyde-O-(substituted) Benzyl Oximes 169
Spirocyclic Benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel 169
New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection 169
Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer's disease? 169
Pharmacological study on the cardiovascular activity of no-sartans, pharmacodynamic hybridsexhibiting at1-antagonist and no-donor properties 168
Epibatidine: A Promising Natural Alkaloid in Health 168
Synthesis and functional evaluation of novel aldose reductase inhibitors bearing a spirobenzopyran scaffold 167
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 166
Development of Classification Models for Identifying “True” P-glycoprotein (P-gp) Inhibitors Through Inhibition, ATPase Activation and Monolayer Efflux Assays 166
ANTI-ISCHEMIC PROPERTIES OF A NEW SPIRO-CYCLIC BENZOPYRAN ACTIVATOR OF CARDIAC MITOCHONDRIAL ATP-SENSITIVE POTASSIUM CHANNELS 165
Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel 163
NO-Sartans: A New Class of Pharmacodynamic Hybrids as Cardiovascular Drugs 161
A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs 161
Mitochondrial Potassium Channels as Pharmacological Target for Cardioprotective Drugs 161
Oxidative stress, mitochondrial abnormalities and proteins deposition: multitarget approaches in Alzheimer's disease 160
New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties 159
Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands 159
New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) 159
Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase 158
Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands 158
Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids 157
New spiromorpholone- and spiromorpholine-benzopyrane derivatives as potential activators of mito-KATP channel 155
Novel adenosine 5'-triphosphate-sensitive potassium channel ligands: a patent overview (2005 - 2010) 155
Endogenous 3-iodothyronamine (T1Am) and synthetic thyronamine-like analog SG-2 act as novel pleiotropic neuroprotective agents through the modulation of SIRT6 155
Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells 154
Synthesis of a Resveratrol Analogue with High Ceramide-Mediated Proapoptotic Activity on Human Breast Cancer Cells 154
Dual PDK1/aurora kinase a inhibitors reduce pancreatic cancer cell proliferation and colony formation 154
(E)-[2-(4-Methylsulphonylphenyl)-1-cyclopentenyl-1-methyliden]-(arylmethyloxy)amines. Methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: synthesis and biological properties 153
New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2 152
Ceramide analogues in apoptosis: a new strategy for anticancer drug development 152
Targeting the upregulated PI3K-PDK1-Akt pathway: a drug discovery approach of treating cancer. 151
Cardiac ATP-sensitive potassium channels, a potential target for an anti-ischaemic pharmacological strategy 151
Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents 151
Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity 151
H2S-RELEASING PROPERTIES OF NEW THIOAMIDE, IMINOTHIOETHER AND ISOTHIOCYANATE DERIVATIVES 150
Antiarrhythmic activity of a new spiro-cyclic benzopyran activator of the cardiac mitochondrial ATP dependent potassium channels 150
P-gp Transporter and its Role in Neurodegenerative Diseases 147
Hydrogen sulfide: A worthwhile tool in the design of new multitarget drugs 146
Classification models for the identification of P-gp inhibitors 145
Synthesis and biological evaluation of (Hetero)aryl-methyloxyphenyl derivatives as potent P-glycoprotein modulating agents. 140
SG‐2: A SYNTHETIC ANALOG OF THYROID HORMONE METABOLITE 3‐IODOTHYRONAMINE (T1AM), PREVENTS β‐AMYLOID NEUROTOXICITY IN VITRO 140
NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs 140
Synthesis, Antifungal Activity, and Molecular Modeling Studies of New Inverted Oxime Ethers of Oxiconazole 139
Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD 139
Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties 138
Novel Estrogen Receptor Ligands Based on an Anthranylaldoxime Structure: Role of the Phenol-Type Pseudocycle in the Binding Process 138
Symbiotic approach applied to the synthesis of new agents for the treatment of Alzheimer’s disease 138
Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer 138
Synthesis and prostaglandin synthase inhibitory activity of new aromatic O-alkyloxime ethers substituted with methylsulfonamido or methylsulfonyl groups on their aliphatic portion 137
Evaluation of the NO-releasing properties of NO-donor linkers 137
Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells 136
Derivati arilpiperazinici quali inibitori della Glicoproteina-P (P-gp) utili nella Multidrug Resistance (MDR) indotta da chemioterapici 136
Synthesis of new potent P-glycoprotein inhibitors and their screening: potential tools to reduce the multidrug resistance 135
Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity 135
Aminobenzothiazoles as beta-Selective Estrogen Receptor Ligands 134
Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity 134
Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis 134
Synthesis and Affinity Evaluation for AT1 Receptor of Phenylsalicylaldoxime-Derivatives Structurally Related to Sartans 132
null 132
Synthesis and Biological Evaluation of Cyclopropylamine Vitamin D‐Like CYP24A1 Inhibitors 132
Synthesis and COX2 inhibitory properties of N-Phenyl-and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene, and isoxazole analogs 131
Areca catechu—From farm to food and biomedical applications 130
Classification models for the identification of P-gp inhibitors. 129
Iminothioethers as a novel class of H2S-donor: gasotransmitter release and vascular effects 127
Multi-targeted ChEI-copper chelating molecules as neuroprotective agents 127
THIOAMIDE, IMINOTHIOETHER AND ISOTHIOCYANATE DERIVATIVES: CHEMOTYPES OF SLOW H2S-RELEASING AGENTS 126
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW 7BETA-(BENZO[A]DIHYDROCARBAZOLYLOXYACETYL)-SUBSTITUTED CEPHALOSPORINS 126
alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors 125
COMPOSTI 2-OXO-1,2-DIIDROPIRIDIN-3-CARBOSSAMMIDE E LORO USO COME INIBITORI DI PDK1. 125
Totale 16.492
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Categoria #
all - tutte 80.137
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 80.137
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.301 0 0 0 0 159 126 150 145 247 120 94 260
2021/20222.354 33 185 69 126 379 317 89 127 72 90 142 725
2022/20233.180 382 393 218 260 323 462 19 220 617 35 162 89
2023/20242.483 323 281 277 167 337 387 137 46 29 84 92 323
2024/20256.579 55 311 136 384 553 628 718 357 644 871 695 1.227
2025/20263.160 536 897 780 575 372 0 0 0 0 0 0 0
Totale 28.525