RAPPOSELLI, SIMONA
 Distribuzione geografica
Continente #
NA - Nord America 14.447
AS - Asia 6.679
EU - Europa 6.665
SA - Sud America 947
AF - Africa 271
OC - Oceania 19
Continente sconosciuto - Info sul continente non disponibili 5
Totale 29.033
Nazione #
US - Stati Uniti d'America 14.011
IT - Italia 2.472
CN - Cina 2.184
SG - Singapore 2.079
HK - Hong Kong 1.135
SE - Svezia 1.007
DE - Germania 926
BR - Brasile 815
BG - Bulgaria 518
CA - Canada 368
TR - Turchia 364
VN - Vietnam 315
GB - Regno Unito 286
FR - Francia 270
RU - Federazione Russa 246
FI - Finlandia 227
AT - Austria 183
UA - Ucraina 160
IN - India 132
CI - Costa d'Avorio 96
KR - Corea 94
PL - Polonia 82
JP - Giappone 74
CH - Svizzera 57
NL - Olanda 57
BD - Bangladesh 47
BE - Belgio 45
SN - Senegal 39
AR - Argentina 38
CZ - Repubblica Ceca 37
MX - Messico 34
NG - Nigeria 32
IQ - Iraq 31
ZA - Sudafrica 31
ID - Indonesia 29
SA - Arabia Saudita 29
ES - Italia 27
MA - Marocco 22
PK - Pakistan 21
EC - Ecuador 18
VE - Venezuela 18
AU - Australia 17
CO - Colombia 16
PH - Filippine 16
UZ - Uzbekistan 16
IL - Israele 15
LT - Lituania 15
EG - Egitto 14
CL - Cile 11
IR - Iran 11
PE - Perù 10
JO - Giordania 9
MY - Malesia 9
PY - Paraguay 9
KZ - Kazakistan 8
UY - Uruguay 8
AE - Emirati Arabi Uniti 7
JM - Giamaica 7
LB - Libano 7
AZ - Azerbaigian 6
IE - Irlanda 6
NP - Nepal 6
PA - Panama 6
TW - Taiwan 6
BJ - Benin 5
CR - Costa Rica 5
DO - Repubblica Dominicana 5
GR - Grecia 5
KE - Kenya 5
OM - Oman 5
TH - Thailandia 5
TN - Tunisia 5
AL - Albania 4
DZ - Algeria 4
GA - Gabon 4
PS - Palestinian Territory 4
PT - Portogallo 4
BB - Barbados 3
BO - Bolivia 3
EE - Estonia 3
EU - Europa 3
GH - Ghana 3
KH - Cambogia 3
LK - Sri Lanka 3
LV - Lettonia 3
MK - Macedonia 3
NO - Norvegia 3
RO - Romania 3
RS - Serbia 3
TT - Trinidad e Tobago 3
A1 - Anonimo 2
AO - Angola 2
DK - Danimarca 2
GE - Georgia 2
HN - Honduras 2
HR - Croazia 2
HU - Ungheria 2
LU - Lussemburgo 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
Totale 29.010
Città #
Ashburn 1.587
Woodbridge 1.545
Singapore 1.186
Hong Kong 1.126
Fairfield 1.046
Ann Arbor 964
Chandler 921
Houston 905
Santa Clara 727
Dallas 719
Serra 675
Shanghai 589
Milan 535
Sofia 518
Beijing 504
Seattle 442
Wilmington 370
Cambridge 349
New York 319
Ottawa 306
Boardman 290
Princeton 245
Izmir 244
Los Angeles 221
Lawrence 202
Jacksonville 188
Medford 178
Vienna 170
Pisa 156
Nanjing 154
Des Moines 126
Hefei 123
Frankfurt am Main 114
Abidjan 96
Chicago 95
Redondo Beach 91
Istanbul 88
Rome 88
London 83
Dong Ket 79
Munich 79
Florence 77
Redwood City 76
Seoul 76
Dearborn 74
Marseille 74
Nanchang 71
Warsaw 71
São Paulo 68
Buffalo 67
Tokyo 63
Council Bluffs 61
San Diego 60
Bern 50
Shenyang 48
Boulder 45
Brussels 44
The Dalles 43
Ho Chi Minh City 42
Dakar 39
Ogden 39
Turku 38
Nürnberg 37
Columbus 36
Norwalk 36
Hebei 35
Lucca 34
Rio de Janeiro 34
Hanoi 31
Lagos 31
Bremen 30
Brno 30
Carrara 30
San Francisco 30
Hangzhou 28
Livorno 28
Nuremberg 27
Pescara 27
Phoenix 27
Pune 27
Belo Horizonte 26
Changsha 26
Fort Wayne 26
Kunming 26
Toronto 25
Washington 25
Helsinki 24
Auburn Hills 23
Düsseldorf 23
Fuzhou 23
Genoa 23
Jüchen 23
Tianjin 23
Pessac 21
San Jose 21
Montreal 20
Paris 20
Wuhan 20
Amsterdam 19
Brasília 19
Totale 20.683
Nome #
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS INHIBITORS OF PDK1 (US Patent App. 15/735,468, 2018) 284
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme 279
Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer 278
2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS DUAL INHIBITORS OF PDK1/AURA 275
A patent update on PDK1 inhibitors (2015-present) 262
Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects 248
Multifunctional Drugs: New challenging chimeras in medicinal chemistry and drug discovery 232
Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma 215
Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells 214
Synthesis and evaluation of multi-functional NO-donor/insulin-secretagogue derivatives for the treatment of type II diabetes and its cardiovascular complications 213
New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design,Synthesis, and Biopharmacological Properties 209
Dual inhibition of PDK1 and Aurora Kinase A: an effective strategy to induce differentiation and apoptosis of human glioblastoma multiforme stem cells 207
Memantine prodrug as a new agent for alzheimer’s disease 206
A NEW NITRIC OXIDE RELEASING ANTI-DIABETIC HYBRID DRUG: FROM THE DESIGN TO THE PHARMACOLOGICAL CHARACTERIZATION 204
Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease 203
Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease 201
Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes 195
Synthesis and AT1 affinity evaluation of benzamidophenyl analogs of known AT1 receptor ligands with similar aromatic skeleton 195
Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein 192
Enantiopure 3-(arylmethylidene)aminoxy-2-methylpropionic acids: synthesis and antiinflammatory properties 191
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 190
Arylthioamides as H2S Donors:l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo 189
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 187
SAR study on arylmethyloxyphenyl scaffold: Looking for a P-gp nanomolar affinity 186
In-vitro evaluation of new pharmacodynamic hybrids with insulin secretagogue and NO-donor activity 184
Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors 181
Dimer of rivastigmine and caffeic acid or ferulic acid, preparation method and drug composition thereof 181
Endogenous TH metabolite 3-iodothyronamine (T1AM) and synthetic thyronamine-like analogues SG-1 and SG-2 induce autophagy in human glioblastoma cells (U-87MG) 180
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 178
Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition 177
Spirocyclic Benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel 177
The pleiotropic functionality of endogenous 3-iodothyronamine (T1AM) and synthetic thyronamine-like analogs: a powerful tool to target interlinked diseases such as obesity and neurodegeneration 177
Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer's disease? 177
Synthesis and 5-HT2A, 5-HT1Aand a1-Binding Affinities of 2-[2- Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-Hydroxy-3-(2- pyridin-2-yl-ethyl)amino]- and 2-[2-Hydroxy-3-(4-N-methylpiperazin- 1-yl)-amino]propoxybenzaldehyde-O-(substituted) Benzyl Oximes 175
Epibatidine: A Promising Natural Alkaloid in Health 175
Development of Classification Models for Identifying “True” P-glycoprotein (P-gp) Inhibitors Through Inhibition, ATPase Activation and Monolayer Efflux Assays 174
New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection 173
Pharmacological study on the cardiovascular activity of no-sartans, pharmacodynamic hybridsexhibiting at1-antagonist and no-donor properties 171
ANTI-ISCHEMIC PROPERTIES OF A NEW SPIRO-CYCLIC BENZOPYRAN ACTIVATOR OF CARDIAC MITOCHONDRIAL ATP-SENSITIVE POTASSIUM CHANNELS 171
Synthesis and functional evaluation of novel aldose reductase inhibitors bearing a spirobenzopyran scaffold 171
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 169
New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties 165
Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands 165
NO-Sartans: A New Class of Pharmacodynamic Hybrids as Cardiovascular Drugs 165
Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel 165
Mitochondrial Potassium Channels as Pharmacological Target for Cardioprotective Drugs 165
New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) 164
Oxidative stress, mitochondrial abnormalities and proteins deposition: multitarget approaches in Alzheimer's disease 164
Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids 164
A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs 163
Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase 163
Dual PDK1/aurora kinase a inhibitors reduce pancreatic cancer cell proliferation and colony formation 163
Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands 163
Endogenous 3-iodothyronamine (T1Am) and synthetic thyronamine-like analog SG-2 act as novel pleiotropic neuroprotective agents through the modulation of SIRT6 161
Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells 160
Synthesis of a Resveratrol Analogue with High Ceramide-Mediated Proapoptotic Activity on Human Breast Cancer Cells 160
New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2 159
(E)-[2-(4-Methylsulphonylphenyl)-1-cyclopentenyl-1-methyliden]-(arylmethyloxy)amines. Methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: synthesis and biological properties 159
Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents 159
New spiromorpholone- and spiromorpholine-benzopyrane derivatives as potential activators of mito-KATP channel 158
Novel adenosine 5'-triphosphate-sensitive potassium channel ligands: a patent overview (2005 - 2010) 158
Cardiac ATP-sensitive potassium channels, a potential target for an anti-ischaemic pharmacological strategy 156
Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity 156
H2S-RELEASING PROPERTIES OF NEW THIOAMIDE, IMINOTHIOETHER AND ISOTHIOCYANATE DERIVATIVES 155
Targeting the upregulated PI3K-PDK1-Akt pathway: a drug discovery approach of treating cancer. 155
Ceramide analogues in apoptosis: a new strategy for anticancer drug development 154
Antiarrhythmic activity of a new spiro-cyclic benzopyran activator of the cardiac mitochondrial ATP dependent potassium channels 153
P-gp Transporter and its Role in Neurodegenerative Diseases 150
Hydrogen sulfide: A worthwhile tool in the design of new multitarget drugs 150
Classification models for the identification of P-gp inhibitors 149
Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer 147
Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells 145
Novel Estrogen Receptor Ligands Based on an Anthranylaldoxime Structure: Role of the Phenol-Type Pseudocycle in the Binding Process 145
SG‐2: A SYNTHETIC ANALOG OF THYROID HORMONE METABOLITE 3‐IODOTHYRONAMINE (T1AM), PREVENTS β‐AMYLOID NEUROTOXICITY IN VITRO 145
Symbiotic approach applied to the synthesis of new agents for the treatment of Alzheimer’s disease 144
Synthesis and prostaglandin synthase inhibitory activity of new aromatic O-alkyloxime ethers substituted with methylsulfonamido or methylsulfonyl groups on their aliphatic portion 143
Synthesis and biological evaluation of (Hetero)aryl-methyloxyphenyl derivatives as potent P-glycoprotein modulating agents. 143
NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs 143
Synthesis, Antifungal Activity, and Molecular Modeling Studies of New Inverted Oxime Ethers of Oxiconazole 142
Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD 142
Evaluation of the NO-releasing properties of NO-donor linkers 141
Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties 140
Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis 140
Synthesis of new potent P-glycoprotein inhibitors and their screening: potential tools to reduce the multidrug resistance 139
Aminobenzothiazoles as beta-Selective Estrogen Receptor Ligands 139
Derivati arilpiperazinici quali inibitori della Glicoproteina-P (P-gp) utili nella Multidrug Resistance (MDR) indotta da chemioterapici 139
Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity 138
Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity 138
Synthesis and Biological Evaluation of Cyclopropylamine Vitamin D‐Like CYP24A1 Inhibitors 136
Classification models for the identification of P-gp inhibitors. 134
Synthesis and Affinity Evaluation for AT1 Receptor of Phenylsalicylaldoxime-Derivatives Structurally Related to Sartans 133
Synthesis and COX2 inhibitory properties of N-Phenyl-and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene, and isoxazole analogs 133
Areca catechu—From farm to food and biomedical applications 133
null 132
Multi-targeted ChEI-copper chelating molecules as neuroprotective agents 132
THIOAMIDE, IMINOTHIOETHER AND ISOTHIOCYANATE DERIVATIVES: CHEMOTYPES OF SLOW H2S-RELEASING AGENTS 131
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW 7BETA-(BENZO[A]DIHYDROCARBAZOLYLOXYACETYL)-SUBSTITUTED CEPHALOSPORINS 131
Iminothioethers as a novel class of H2S-donor: gasotransmitter release and vascular effects 130
alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors 129
Sodium N-(Methylsulfonyl)-N-(4-nitro- 2-phenoxyphenyl)sulfamate: A Water-Soluble Nimesulide Prodrug for Parenteral Use 129
Totale 17.003
Categoria #
all - tutte 82.861
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 82.861


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.142 0 0 0 0 0 126 150 145 247 120 94 260
2021/20222.354 33 185 69 126 379 317 89 127 72 90 142 725
2022/20233.180 382 393 218 260 323 462 19 220 617 35 162 89
2023/20242.483 323 281 277 167 337 387 137 46 29 84 92 323
2024/20256.579 55 311 136 384 553 628 718 357 644 871 695 1.227
2025/20264.242 536 897 780 575 852 602 0 0 0 0 0 0
Totale 29.607