CINECA IRIS Institutional Research Information System

MACCHIA, MARCO
 Distribuzione geografica
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Continente #
NA - Nord America 22.128
AS - Asia 10.362
EU - Europa 9.730
SA - Sud America 1.590
AF - Africa 398
OC - Oceania 33
Continente sconosciuto - Info sul continente non disponibili 10
Totale 44.251
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Nazione #
US - Stati Uniti d'America 21.458
IT - Italia 3.610
SG - Singapore 3.229
CN - Cina 3.158
HK - Hong Kong 1.707
SE - Svezia 1.556
DE - Germania 1.359
BR - Brasile 1.341
BG - Bulgaria 754
TR - Turchia 580
CA - Canada 536
GB - Regno Unito 508
VN - Vietnam 470
FI - Finlandia 375
RU - Federazione Russa 355
IN - India 303
UA - Ucraina 296
KR - Corea 283
FR - Francia 266
AT - Austria 160
JP - Giappone 135
CH - Svizzera 100
AR - Argentina 80
NG - Nigeria 76
BD - Bangladesh 73
CI - Costa d'Avorio 71
NL - Olanda 70
PL - Polonia 59
IQ - Iraq 58
BE - Belgio 55
MX - Messico 54
ZA - Sudafrica 53
PK - Pakistan 52
MA - Marocco 48
SA - Arabia Saudita 47
ID - Indonesia 46
ES - Italia 45
SN - Senegal 39
EC - Ecuador 38
UZ - Uzbekistan 38
VE - Venezuela 34
GR - Grecia 28
CO - Colombia 26
AU - Australia 25
CZ - Repubblica Ceca 24
EG - Egitto 21
KE - Kenya 21
PY - Paraguay 21
IL - Israele 20
LT - Lituania 20
IE - Irlanda 18
AZ - Azerbaigian 17
CL - Cile 15
PE - Perù 14
UY - Uruguay 14
AE - Emirati Arabi Uniti 13
MY - Malesia 13
TT - Trinidad e Tobago 13
BJ - Benin 12
KZ - Kazakistan 12
PA - Panama 12
MO - Macao, regione amministrativa speciale della Cina 11
RS - Serbia 11
TN - Tunisia 11
BB - Barbados 10
DO - Repubblica Dominicana 10
IR - Iran 10
JM - Giamaica 10
JO - Giordania 10
DZ - Algeria 9
RO - Romania 9
BY - Bielorussia 8
NP - Nepal 8
NZ - Nuova Zelanda 8
PS - Palestinian Territory 8
CR - Costa Rica 7
ET - Etiopia 7
OM - Oman 7
EU - Europa 6
GA - Gabon 6
GE - Georgia 6
PT - Portogallo 6
SK - Slovacchia (Repubblica Slovacca) 6
TW - Taiwan 6
AL - Albania 5
BA - Bosnia-Erzegovina 5
LB - Libano 5
QA - Qatar 5
TH - Thailandia 5
BN - Brunei Darussalam 4
BO - Bolivia 4
DK - Danimarca 4
HU - Ungheria 4
KG - Kirghizistan 4
LK - Sri Lanka 4
SV - El Salvador 4
AO - Angola 3
BW - Botswana 3
DM - Dominica 3
GY - Guiana 3
Totale 44.189
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Città #
Woodbridge 2.569
Ashburn 2.210
Ann Arbor 1.935
Singapore 1.783
Hong Kong 1.698
Houston 1.590
Fairfield 1.551
Chandler 1.413
Serra 1.186
Santa Clara 1.178
Dallas 1.070
Sofia 753
Shanghai 702
Beijing 639
Seattle 617
Wilmington 587
Cambridge 546
New York 460
Ottawa 435
Izmir 386
Hefei 379
Milan 377
Boardman 359
Jacksonville 340
Princeton 335
Los Angeles 320
Lawrence 290
Seoul 270
Nanjing 258
Medford 256
Des Moines 178
Munich 174
Pisa 173
Dearborn 163
Florence 151
Istanbul 140
Vienna 134
Dong Ket 131
Buffalo 126
Redondo Beach 125
Marseille 124
London 118
Nanchang 117
São Paulo 116
Rome 99
Tokyo 99
The Dalles 93
Columbus 92
Redwood City 91
San Diego 87
Bern 86
Lagos 75
Council Bluffs 73
Lucca 70
Abidjan 69
Turku 69
Frankfurt am Main 68
Ho Chi Minh City 64
Boulder 63
Ogden 61
Kunming 58
Nürnberg 56
Pune 52
Jüchen 51
Shenyang 51
Fuzhou 49
Chicago 47
Warsaw 45
Belo Horizonte 44
Livorno 43
Hanoi 40
San Francisco 40
Brussels 39
Dakar 39
Norwalk 37
Helsinki 36
Tashkent 36
Düsseldorf 35
Guangzhou 34
Jakarta 34
Tianjin 34
Mumbai 33
San Jose 33
Hebei 32
Bremen 31
Nuremberg 31
Pistoia 31
Brooklyn 30
Casablanca 30
Rio de Janeiro 30
Jiaxing 29
Phoenix 28
Hangzhou 27
Montreal 27
Toronto 27
Baghdad 26
Grafing 26
Washington 26
Brasília 25
Johannesburg 25
Totale 31.168
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Nome #
COMPOSTO INIBITORE DELL’ENZIMA LATTATO DEIDROGENASI (LDH) E COMPOSIZIONE FARMACEUTICA CHE COMPRENDE TALE COMPOSTO 346
Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells 339
4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors 315
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme 279
Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase. 252
Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts 232
Application of An Improved HPLC-FL Method to Screen Serine Palmitoyl Transferase Inhibitors 230
Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents 227
Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer 227
Diversity of yeast community composition in olive oil from two different areas in Tuscany 222
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity 216
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system 214
New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design,Synthesis, and Biopharmacological Properties 209
A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by using a Pharmacophore-Based Approach 204
Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors 204
Anti-proliferative activity of oleocanthal in human malignant cutaneous melanoma cells 203
HPLC determination of urinary 2,4- and 2,6-toluendiamines as potential degradation products of polyurethane breast implants 200
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor 200
1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor 198
Identification of the first synthetic allosteric modulator of the CB2receptors and evidence of its efficacy for neuropathic pain relief 196
Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes 195
Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors 192
CONFORMATIONALLY RESTRAINED ANALOGS OF SYMPATHOMIMETIC CATECHOLAMINES - SYNTHESIS AND ADRENERGIC ACTIVITY OF TETRAHYDROBENZOCYCLOHEPTENE DERIVATIVES 192
The [(Methyloxy)imino]methyl Moiety as a Bioisoster of Aryl. A Novel Class of Completely Aliphatic Beta-Adrenergic Receptor Antagonists 192
Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase 192
Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein 192
Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials 192
Rational Development of MAGL Inhibitors 192
Synthesis and α2-adrenergic activity of 2-[(methyleneamino)oxy]-N-(guanidino)ethaneimines. A bioisosteric replacement of the aryl of guanabenz-type benzylideneaminoguanidine α2-agonists with the [(methyleneamino)oxy]methyl moiety (MAOMM) 191
Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma 191
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 190
Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor 190
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands 189
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 188
Rational design, synthesis, biological evaluation and labelling of selective cannabinoid CB2 receptor agonists as anticancer agents 187
Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform a (LDH-A) as Starvation Agents against Cancer Cells 187
SAR study on arylmethyloxyphenyl scaffold: Looking for a P-gp nanomolar affinity 186
Design, synthesis and preliminary evaluation of (18)F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor 186
Efficient application of monolithic silica column to determination of illicit heroin street sample by HPLC 185
3-(METHYLENEAMINOXY)METHYLPIPERIDINE DERIVATIVES AS UPTAKE INHIBITORS OF BIOGENIC-AMINES IN THE BRAIN SYNAPTOSOMAL FRACTION 184
CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides 184
Structural optimization of 4-chlorobenzoylpiperidine derivatives for the development of potent, reversible and selective monoacylglycerol lipase (MAGL) inhibitors 184
The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation 184
Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand 183
COMPOUNDS INHIBITING THE ENZYME LACTATE DEHYDROGENASE (LDH), PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 183
Composition of health-promoting phenolic compounds in two extra-virgin olive oils and diversity of associated yeasts 182
4-[6-(dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor 182
SYNTHESIS, ANTIINFLAMMATORY ACTIVITY AND MOLECULAR-ORBITAL STUDIES OF A SERIES OF BENZYLIDENEAMINOXYPROPIONIC ACIDS SUBSTITUTED ON THE PHENYL RING 181
Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors 181
Antiproliferative oxime derivatives that inhibit glucose transporter 1 (GLUT1) in cancer cells 181
Dimer of rivastigmine and caffeic acid or ferulic acid, preparation method and drug composition thereof 181
Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: Implications for drug discovery 181
Waste autochthonous tuscan olive leaves (Olea europaea var. olivastra seggianese) as antioxidant source for biomedicine 181
Conformationally Restrained Analogs of Sympathomimetic Catecholamines. Synthesis, Conformational Analysis, and Adrenergic Activity of Isochroman Derivatives 181
Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors 179
Hypoxia-activated lysyl oxidase (LOX) inhibitors in the treatment of highly invasive and metastatic cancer 178
Estrogen receptor ligands: a patent review update 178
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 178
Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system 178
Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells 177
Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition 177
Synthesis and ß-adrenergic properties of (E)-N-[3-(alkylamino)-2- hydroxypropilidene](methyloxy)amines substituted with an aromatic group on their [(methyloxy)imino]methyl moiety (MOIMM): an investigation into the biopharmacological effects of an aryl substitution in the class of MOIM ß-blocking drugs. 175
Conformationally restrained ß-blocking oxime ethers. 2. Synthesis and ß-adrenergic properties of diastereoisomeric anti and syn 2-(5’-(3’-aryl-substituted)isoxazolidinyl)-N-alkylethanolamines 174
Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor 174
Highly Selective Salicylketoxime-Based Estrogen Receptor β Agonists Display Antiproliferative Activities in a Glioma Model 174
Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands 174
7-Nitrobenzofurazan (NBD)-Derivatives Of 5'-N-Ethylcarboxamidoadenosine (NECA) As New Fluorescent Probes For Human A3 Adenosine Receptors 173
(Z)-(Methyloxyiminomethyl)ethanolamines. Effects of the configuration around the iminic double bond on the beta-adrenergic affinity of moim-type beta-adrenergic blocking agents 172
Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells 172
Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells 171
2-(Methyleneaminoxy)methylmorpholine derivatives. Synthesis and antidepressant activity 171
Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes 170
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors 170
A new D2 dopamine receptor agonist allosterically modulates A2A adenosine receptor signalling by interacting with the A2A/D2 receptor heteromer 170
Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors 170
Synthesis and antimicrobial activity of 7ß-(S) and 7ß-(R)-3-(methyleneaminoxy)-2-methylpropionamido substituted cephalosporanic acid derivatives 169
The phenolic compounds tyrosol and hydroxytyrosol counteract liver fibrogenesis via the transcriptional modulation of NADPH oxidases and oxidative stress-related miRNAs 168
Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors 168
Conformationally restrained beta-blocking oxime ethers: synthesis and beta-adrenergic properties of diastereoisomeric anti and syn 2-(5-isoxazolidinyl)ethanolamines 168
3-(Methyleneaminoxy)methylpiperidine derivatives as uptake inhibitors of biogenic amines in the brain synaptosomal fraction 168
Selective activators of estrogen receptor beta based on the aldoxime and ketoxime scaffolds 167
Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis 167
Synthesis and adrenergic ß-blocking activity of (oxypropanolamino)-substituted [(benzylideneamino)oxy]propanolamines 167
A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress 167
Olive Mill Wastewater as Source of Polyphenols with Nutraceutical Properties 165
Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands 165
Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds 165
New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) 164
Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5 164
Biphenyl-Derivatives Possessing Tertiary Amino Groups as ß-Secretase (BACE1) Inhibitors 163
Synthesis and aldose reductase inhibitory activity of N-(arylsulfonyl)- and N-(aroyl)-N-(arylmethyloxy)glycines 163
Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells 163
Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology. 162
N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation 162
Preclinical emergence of novel lactate dehydrogenase inhibitors as potent antitumor agents in hypoxic models of pancreatic cancer: molecular mechanisms underlying their synergistic interaction with gemcitabine 160
Synthesis of a Resveratrol Analogue with High Ceramide-Mediated Proapoptotic Activity on Human Breast Cancer Cells 160
Glycosaminoglycans provide a binding site for thyroglobulin in orbital tissues of patients with thyroid-associated ophthalmopathy 160
Synthesis and ß-Adrenergic Properties Of (Z)-N-[3-(Alkylamino)-2-hydroxypropilidene](aryl-methyloxy)amines: Effects Of The Configuration Around The Methyloxyiminomethyl(MOIM) Double Bond On The Biopharmacological Properties Of MOIM-type ß-Blocking Agents 159
Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents 159
1-benzilossiimmino-3- ammino-2-propanoli: sintesi e proprietà ß-adrenergiche 158
Totale 18.811
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Categoria #
all - tutte 120.748
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 120.748
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.605 0 0 0 0 0 150 147 295 298 197 162 356
2021/20223.614 99 342 93 217 563 472 136 176 132 116 204 1.064
2022/20234.384 558 598 336 374 509 569 51 333 674 32 254 96
2023/20242.610 304 275 291 114 386 495 172 65 48 57 100 303
2024/202510.225 52 379 213 592 919 959 849 586 1.002 1.336 1.152 2.186
2025/20266.759 889 1.468 1.374 961 1.033 1.034 0 0 0 0 0 0
Totale 44.955