CINECA IRIS Institutional Research Information System

MACCHIA, MARCO
 Distribuzione geografica
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Continente #
NA - Nord America 24.887
AS - Asia 11.879
EU - Europa 10.611
SA - Sud America 1.712
Continente sconosciuto - Info sul continente non disponibili 731
AF - Africa 447
OC - Oceania 37
Totale 50.304
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Nazione #
US - Stati Uniti d'America 24.103
IT - Italia 3.866
SG - Singapore 3.749
CN - Cina 3.345
HK - Hong Kong 1.761
SE - Svezia 1.585
BR - Brasile 1.408
DE - Germania 1.396
VN - Vietnam 881
BG - Bulgaria 756
TR - Turchia 593
CA - Canada 586
FR - Francia 576
GB - Regno Unito 558
FI - Finlandia 472
IN - India 366
RU - Federazione Russa 362
UA - Ucraina 304
KR - Corea 285
JP - Giappone 267
AT - Austria 163
CH - Svizzera 116
BD - Bangladesh 97
NL - Olanda 97
AR - Argentina 96
NG - Nigeria 78
IQ - Iraq 72
MX - Messico 72
CI - Costa d'Avorio 71
PK - Pakistan 66
PL - Polonia 65
ZA - Sudafrica 60
BE - Belgio 56
SA - Arabia Saudita 56
MA - Marocco 55
ID - Indonesia 54
ES - Italia 53
UZ - Uzbekistan 46
EC - Ecuador 43
SN - Senegal 39
CO - Colombia 38
VE - Venezuela 37
AU - Australia 29
GR - Grecia 29
KE - Kenya 27
CZ - Repubblica Ceca 25
JM - Giamaica 25
PY - Paraguay 24
EG - Egitto 22
IL - Israele 22
CL - Cile 21
IE - Irlanda 20
LT - Lituania 20
MY - Malesia 19
AZ - Azerbaigian 18
TN - Tunisia 18
TT - Trinidad e Tobago 17
UY - Uruguay 17
KZ - Kazakistan 16
PE - Perù 16
AE - Emirati Arabi Uniti 15
PH - Filippine 15
CR - Costa Rica 14
DZ - Algeria 14
JO - Giordania 14
NP - Nepal 13
PA - Panama 13
BJ - Benin 12
BY - Bielorussia 12
ET - Etiopia 12
BB - Barbados 11
DO - Repubblica Dominicana 11
MO - Macao, regione amministrativa speciale della Cina 11
RO - Romania 11
RS - Serbia 11
GE - Georgia 10
IR - Iran 10
PR - Porto Rico 9
PS - Palestinian Territory 9
BO - Bolivia 8
NZ - Nuova Zelanda 8
OM - Oman 8
BA - Bosnia-Erzegovina 7
LB - Libano 7
PT - Portogallo 7
SK - Slovacchia (Repubblica Slovacca) 7
TH - Thailandia 7
AL - Albania 6
AO - Angola 6
EU - Europa 6
GA - Gabon 6
QA - Qatar 6
TW - Taiwan 6
HN - Honduras 5
HR - Croazia 5
KG - Kirghizistan 5
SV - El Salvador 5
BN - Brunei Darussalam 4
DK - Danimarca 4
GY - Guiana 4
Totale 49.488
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Città #
Woodbridge 2.570
Ashburn 2.479
Singapore 2.157
Ann Arbor 1.935
Hong Kong 1.741
Houston 1.600
Fairfield 1.551
Chandler 1.413
San Jose 1.330
Santa Clara 1.209
Serra 1.186
Dallas 1.088
Sofia 754
Shanghai 707
Beijing 665
Seattle 619
Wilmington 588
Cambridge 546
New York 481
Ottawa 435
Milan 396
Izmir 386
Hefei 379
Boardman 360
Los Angeles 350
Jacksonville 343
Princeton 336
Lawrence 290
Council Bluffs 276
Seoul 271
Lauterbourg 269
Nanjing 258
Medford 257
Tokyo 229
Ho Chi Minh City 216
Pisa 191
Des Moines 180
Munich 174
Dearborn 163
Florence 153
Istanbul 144
Vienna 136
Dong Ket 131
Buffalo 130
Helsinki 130
Marseille 126
Redondo Beach 126
Hanoi 125
London 123
São Paulo 123
Nanchang 117
Rome 114
Columbus 113
The Dalles 95
Redwood City 91
Frankfurt am Main 89
San Diego 88
Bern 86
Orem 81
Lagos 77
Lucca 70
Abidjan 69
Turku 69
Boulder 63
Ogden 61
Chicago 59
Kunming 58
Nürnberg 56
Pune 55
Jüchen 51
Shenyang 51
Fuzhou 50
San Francisco 48
Warsaw 46
Livorno 45
Belo Horizonte 44
Tashkent 41
Chennai 40
Brussels 39
Dakar 39
Mumbai 39
Nuremberg 38
Norwalk 37
Phoenix 37
Düsseldorf 36
Guangzhou 36
Jakarta 36
Tianjin 35
Baghdad 34
Amsterdam 32
Brooklyn 32
Hebei 32
Rio de Janeiro 32
Bremen 31
Montreal 31
Pistoia 31
Toronto 31
Casablanca 30
Atlanta 29
Denver 29
Totale 34.498
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Nome #
Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells 374
COMPOSTO INIBITORE DELL’ENZIMA LATTATO DEIDROGENASI (LDH) E COMPOSIZIONE FARMACEUTICA CHE COMPRENDE TALE COMPOSTO 362
4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors 332
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme 304
Synthesis and biological evaluation of (Hetero)aryl-methyloxyphenyl derivatives as potent P-glycoprotein modulating agents. 273
Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase. 265
Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer 258
Olive Mill Wastewater as Source of Polyphenols with Nutraceutical Properties 247
Application of An Improved HPLC-FL Method to Screen Serine Palmitoyl Transferase Inhibitors 247
Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts 246
Diversity of yeast community composition in olive oil from two different areas in Tuscany 245
Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents 238
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity 232
Identification of the first synthetic allosteric modulator of the CB2receptors and evidence of its efficacy for neuropathic pain relief 228
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system 224
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor 222
Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor 222
Structural optimization of 4-chlorobenzoylpiperidine derivatives for the development of potent, reversible and selective monoacylglycerol lipase (MAGL) inhibitors 221
Anti-proliferative activity of oleocanthal in human malignant cutaneous melanoma cells 221
Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors 221
New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design,Synthesis, and Biopharmacological Properties 220
A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by using a Pharmacophore-Based Approach 220
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors 217
Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors 213
1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor 213
Rational Development of MAGL Inhibitors 211
HPLC determination of urinary 2,4- and 2,6-toluendiamines as potential degradation products of polyurethane breast implants 210
Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes 209
Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma 208
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands 207
The [(Methyloxy)imino]methyl Moiety as a Bioisoster of Aryl. A Novel Class of Completely Aliphatic Beta-Adrenergic Receptor Antagonists 206
The phenolic compounds tyrosol and hydroxytyrosol counteract liver fibrogenesis via the transcriptional modulation of NADPH oxidases and oxidative stress-related miRNAs 204
Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors 204
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 204
Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials 204
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 203
Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition 203
SAR study on arylmethyloxyphenyl scaffold: Looking for a P-gp nanomolar affinity 203
Composition of health-promoting phenolic compounds in two extra-virgin olive oils and diversity of associated yeasts 203
Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands 203
The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation 203
Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors 202
Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein 202
Waste autochthonous tuscan olive leaves (Olea europaea var. olivastra seggianese) as antioxidant source for biomedicine 202
Synthesis and α2-adrenergic activity of 2-[(methyleneamino)oxy]-N-(guanidino)ethaneimines. A bioisosteric replacement of the aryl of guanabenz-type benzylideneaminoguanidine α2-agonists with the [(methyleneamino)oxy]methyl moiety (MAOMM) 201
Rational design, synthesis, biological evaluation and labelling of selective cannabinoid CB2 receptor agonists as anticancer agents 201
CONFORMATIONALLY RESTRAINED ANALOGS OF SYMPATHOMIMETIC CATECHOLAMINES - SYNTHESIS AND ADRENERGIC ACTIVITY OF TETRAHYDROBENZOCYCLOHEPTENE DERIVATIVES 201
Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase 201
Dimer of rivastigmine and caffeic acid or ferulic acid, preparation method and drug composition thereof 201
Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: Implications for drug discovery 201
Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform a (LDH-A) as Starvation Agents against Cancer Cells 200
Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor 200
COMPOUNDS INHIBITING THE ENZYME LACTATE DEHYDROGENASE (LDH), PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 200
3-(METHYLENEAMINOXY)METHYLPIPERIDINE DERIVATIVES AS UPTAKE INHIBITORS OF BIOGENIC-AMINES IN THE BRAIN SYNAPTOSOMAL FRACTION 199
Antiproliferative oxime derivatives that inhibit glucose transporter 1 (GLUT1) in cancer cells 198
Efficient application of monolithic silica column to determination of illicit heroin street sample by HPLC 197
Design, synthesis and preliminary evaluation of (18)F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor 197
Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand 195
Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors 194
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 194
Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors 194
4-[6-(dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor 193
(Z)-(Methyloxyiminomethyl)ethanolamines. Effects of the configuration around the iminic double bond on the beta-adrenergic affinity of moim-type beta-adrenergic blocking agents 192
Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system 192
Hypoxia-activated lysyl oxidase (LOX) inhibitors in the treatment of highly invasive and metastatic cancer 191
MolBook UNIPI─Create, Manage, Analyze, and Share Your Chemical Data for Free 190
CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides 190
Estrogen receptor ligands: a patent review update 189
Conformationally Restrained Analogs of Sympathomimetic Catecholamines. Synthesis, Conformational Analysis, and Adrenergic Activity of Isochroman Derivatives 189
SYNTHESIS, ANTIINFLAMMATORY ACTIVITY AND MOLECULAR-ORBITAL STUDIES OF A SERIES OF BENZYLIDENEAMINOXYPROPIONIC ACIDS SUBSTITUTED ON THE PHENYL RING 188
A new D2 dopamine receptor agonist allosterically modulates A2A adenosine receptor signalling by interacting with the A2A/D2 receptor heteromer 188
A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress 188
Conformationally restrained ß-blocking oxime ethers. 2. Synthesis and ß-adrenergic properties of diastereoisomeric anti and syn 2-(5’-(3’-aryl-substituted)isoxazolidinyl)-N-alkylethanolamines 186
Highly Selective Salicylketoxime-Based Estrogen Receptor β Agonists Display Antiproliferative Activities in a Glioma Model 186
Synthesis and ß-adrenergic properties of (E)-N-[3-(alkylamino)-2- hydroxypropilidene](methyloxy)amines substituted with an aromatic group on their [(methyloxy)imino]methyl moiety (MOIMM): an investigation into the biopharmacological effects of an aryl substitution in the class of MOIM ß-blocking drugs. 185
Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells 185
Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells 185
Role of the benzylic hydroxyl group of adrenergic cattecholamines in eliciting alpha-adrenergic activity. Synthesis and alpha1- and alpha2-adrenergic activity of 3-phenyl-3-piperidinols and of their desoxy analogs 184
VenomPred 2.0: A Novel In Silico Platform for an Extended and Human Interpretable Toxicological Profiling of Small Molecules 183
QSAR models for predicting enzymatic hydrolysis of new chemical entities in 'soft-drug' design 183
Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes 182
Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds 182
Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents 182
Conformationally restrained beta-blocking oxime ethers: synthesis and beta-adrenergic properties of diastereoisomeric anti and syn 2-(5-isoxazolidinyl)ethanolamines 181
3-(Methyleneaminoxy)methylpiperidine derivatives as uptake inhibitors of biogenic amines in the brain synaptosomal fraction 181
N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation 181
7-Nitrobenzofurazan (NBD)-Derivatives Of 5'-N-Ethylcarboxamidoadenosine (NECA) As New Fluorescent Probes For Human A3 Adenosine Receptors 180
Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology. 180
Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells 179
Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands 179
Selective activators of estrogen receptor beta based on the aldoxime and ketoxime scaffolds 178
2-(Methyleneaminoxy)methylmorpholine derivatives. Synthesis and antidepressant activity 178
Rutin content in the forage and grain of common buckwheat (Fagopyrum esculentum) as affected by sowing time and irrigation in a Mediterranean environment. 177
Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives 176
New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) 176
Synthesis and adrenergic ß-blocking activity of (oxypropanolamino)-substituted [(benzylideneamino)oxy]propanolamines 176
Synthesis and antimicrobial activity of 7ß-(S) and 7ß-(R)-3-(methyleneaminoxy)-2-methylpropionamido substituted cephalosporanic acid derivatives 175
Antioxidant and neuroprotective activity of extra virgin olive oil extracts obtained from quercetano cultivar trees grown in different areas of the tuscany region (Italy) 175
Fluorescent probes for adenosine receptors: synthesis and biology of n6-dansylaminoalkyl substituted neca derivatives 174
Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5 174
Totale 20.663
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Categoria #
all - tutte 138.879
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 138.879
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20223.515 0 342 93 217 563 472 136 176 132 116 204 1.064
2022/20234.384 558 598 336 374 509 569 51 333 674 32 254 96
2023/20242.610 304 275 291 114 386 495 172 65 48 57 100 303
2024/202510.225 52 379 213 592 919 959 849 586 1.002 1.336 1.152 2.186
2025/202611.569 889 1.468 1.374 961 1.033 1.069 1.733 584 727 954 490 287
2026/2027539 312 227 0 0 0 0 0 0 0 0 0 0
Totale 50.304