CINECA IRIS Institutional Research Information System

MACCHIA, MARCO
 Distribuzione geografica
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Continente #
NA - Nord America 24.415
AS - Asia 11.871
EU - Europa 10.522
SA - Sud America 1.689
AF - Africa 445
OC - Oceania 37
Continente sconosciuto - Info sul continente non disponibili 10
Totale 48.989
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Nazione #
US - Stati Uniti d'America 23.662
IT - Italia 3.825
SG - Singapore 3.749
CN - Cina 3.343
HK - Hong Kong 1.760
SE - Svezia 1.556
BR - Brasile 1.397
DE - Germania 1.396
VN - Vietnam 881
BG - Bulgaria 754
TR - Turchia 593
CA - Canada 575
FR - Francia 571
GB - Regno Unito 558
FI - Finlandia 471
IN - India 362
RU - Federazione Russa 362
UA - Ucraina 303
KR - Corea 285
JP - Giappone 267
AT - Austria 163
CH - Svizzera 116
BD - Bangladesh 97
NL - Olanda 94
AR - Argentina 91
NG - Nigeria 78
IQ - Iraq 72
MX - Messico 72
CI - Costa d'Avorio 71
PK - Pakistan 66
PL - Polonia 64
ZA - Sudafrica 60
BE - Belgio 56
SA - Arabia Saudita 56
MA - Marocco 55
ID - Indonesia 54
ES - Italia 52
UZ - Uzbekistan 46
EC - Ecuador 41
SN - Senegal 39
VE - Venezuela 37
CO - Colombia 36
AU - Australia 29
GR - Grecia 29
KE - Kenya 27
CZ - Repubblica Ceca 25
PY - Paraguay 24
EG - Egitto 22
IL - Israele 22
JM - Giamaica 21
IE - Irlanda 20
LT - Lituania 20
CL - Cile 19
MY - Malesia 19
AZ - Azerbaigian 18
TN - Tunisia 17
KZ - Kazakistan 16
PE - Perù 16
UY - Uruguay 16
AE - Emirati Arabi Uniti 15
PH - Filippine 15
TT - Trinidad e Tobago 15
DZ - Algeria 14
JO - Giordania 14
NP - Nepal 13
PA - Panama 13
BJ - Benin 12
BY - Bielorussia 12
ET - Etiopia 12
BB - Barbados 11
DO - Repubblica Dominicana 11
MO - Macao, regione amministrativa speciale della Cina 11
RS - Serbia 11
CR - Costa Rica 10
GE - Georgia 10
IR - Iran 10
RO - Romania 10
PS - Palestinian Territory 9
BO - Bolivia 8
NZ - Nuova Zelanda 8
OM - Oman 8
BA - Bosnia-Erzegovina 7
LB - Libano 7
PT - Portogallo 7
SK - Slovacchia (Repubblica Slovacca) 7
AL - Albania 6
AO - Angola 6
EU - Europa 6
GA - Gabon 6
QA - Qatar 6
TH - Thailandia 6
TW - Taiwan 6
KG - Kirghizistan 5
SV - El Salvador 5
BN - Brunei Darussalam 4
DK - Danimarca 4
GY - Guiana 4
HR - Croazia 4
HU - Ungheria 4
KH - Cambogia 4
Totale 48.902
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Città #
Woodbridge 2.569
Ashburn 2.421
Singapore 2.157
Ann Arbor 1.935
Hong Kong 1.740
Houston 1.598
Fairfield 1.551
Chandler 1.413
San Jose 1.315
Santa Clara 1.204
Serra 1.186
Dallas 1.085
Sofia 753
Shanghai 707
Beijing 665
Seattle 619
Wilmington 588
Cambridge 546
New York 481
Ottawa 435
Milan 394
Izmir 386
Hefei 379
Boardman 359
Los Angeles 347
Jacksonville 342
Princeton 335
Lawrence 290
Seoul 271
Lauterbourg 269
Nanjing 258
Medford 256
Tokyo 229
Ho Chi Minh City 216
Pisa 188
Des Moines 180
Munich 174
Council Bluffs 167
Dearborn 163
Florence 153
Istanbul 144
Vienna 136
Dong Ket 131
Buffalo 129
Helsinki 129
Marseille 126
Hanoi 125
Redondo Beach 125
London 123
São Paulo 119
Nanchang 117
Rome 113
Columbus 111
The Dalles 95
Redwood City 91
Frankfurt am Main 89
San Diego 88
Bern 86
Orem 80
Lagos 77
Lucca 70
Abidjan 69
Turku 69
Boulder 63
Ogden 61
Kunming 58
Chicago 56
Nürnberg 56
Pune 55
Jüchen 51
Shenyang 51
Fuzhou 50
Warsaw 46
Livorno 45
Belo Horizonte 44
San Francisco 44
Tashkent 41
Chennai 40
Brussels 39
Dakar 39
Mumbai 38
Nuremberg 38
Norwalk 37
Düsseldorf 36
Guangzhou 36
Jakarta 36
Phoenix 36
Tianjin 35
Baghdad 34
Amsterdam 32
Brooklyn 32
Hebei 32
Rio de Janeiro 32
Bremen 31
Pistoia 31
Toronto 31
Casablanca 30
Montreal 30
Denver 29
Jiaxing 29
Totale 34.270
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Nome #
Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells 374
COMPOSTO INIBITORE DELL’ENZIMA LATTATO DEIDROGENASI (LDH) E COMPOSIZIONE FARMACEUTICA CHE COMPRENDE TALE COMPOSTO 360
4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors 329
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme 303
Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase. 265
Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer 254
Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts 246
Application of An Improved HPLC-FL Method to Screen Serine Palmitoyl Transferase Inhibitors 246
Diversity of yeast community composition in olive oil from two different areas in Tuscany 240
Olive Mill Wastewater as Source of Polyphenols with Nutraceutical Properties 239
Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents 238
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity 230
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system 224
Identification of the first synthetic allosteric modulator of the CB2receptors and evidence of its efficacy for neuropathic pain relief 223
Anti-proliferative activity of oleocanthal in human malignant cutaneous melanoma cells 221
New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design,Synthesis, and Biopharmacological Properties 220
Structural optimization of 4-chlorobenzoylpiperidine derivatives for the development of potent, reversible and selective monoacylglycerol lipase (MAGL) inhibitors 220
Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors 220
A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by using a Pharmacophore-Based Approach 219
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor 218
Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor 217
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors 216
Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors 210
Rational Development of MAGL Inhibitors 210
HPLC determination of urinary 2,4- and 2,6-toluendiamines as potential degradation products of polyurethane breast implants 209
Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes 209
Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma 208
1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor 208
The [(Methyloxy)imino]methyl Moiety as a Bioisoster of Aryl. A Novel Class of Completely Aliphatic Beta-Adrenergic Receptor Antagonists 206
The phenolic compounds tyrosol and hydroxytyrosol counteract liver fibrogenesis via the transcriptional modulation of NADPH oxidases and oxidative stress-related miRNAs 203
Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors 203
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 203
Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition 203
SAR study on arylmethyloxyphenyl scaffold: Looking for a P-gp nanomolar affinity 203
Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials 203
Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands 203
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands 202
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 201
Rational design, synthesis, biological evaluation and labelling of selective cannabinoid CB2 receptor agonists as anticancer agents 201
CONFORMATIONALLY RESTRAINED ANALOGS OF SYMPATHOMIMETIC CATECHOLAMINES - SYNTHESIS AND ADRENERGIC ACTIVITY OF TETRAHYDROBENZOCYCLOHEPTENE DERIVATIVES 201
Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein 201
Composition of health-promoting phenolic compounds in two extra-virgin olive oils and diversity of associated yeasts 201
Waste autochthonous tuscan olive leaves (Olea europaea var. olivastra seggianese) as antioxidant source for biomedicine 201
Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor 200
COMPOUNDS INHIBITING THE ENZYME LACTATE DEHYDROGENASE (LDH), PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 200
Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: Implications for drug discovery 200
Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform a (LDH-A) as Starvation Agents against Cancer Cells 199
Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase 199
Dimer of rivastigmine and caffeic acid or ferulic acid, preparation method and drug composition thereof 199
Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors 198
Synthesis and α2-adrenergic activity of 2-[(methyleneamino)oxy]-N-(guanidino)ethaneimines. A bioisosteric replacement of the aryl of guanabenz-type benzylideneaminoguanidine α2-agonists with the [(methyleneamino)oxy]methyl moiety (MAOMM) 198
Efficient application of monolithic silica column to determination of illicit heroin street sample by HPLC 197
3-(METHYLENEAMINOXY)METHYLPIPERIDINE DERIVATIVES AS UPTAKE INHIBITORS OF BIOGENIC-AMINES IN THE BRAIN SYNAPTOSOMAL FRACTION 196
The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation 196
Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand 195
Antiproliferative oxime derivatives that inhibit glucose transporter 1 (GLUT1) in cancer cells 195
Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors 194
Design, synthesis and preliminary evaluation of (18)F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor 194
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 193
Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors 193
(Z)-(Methyloxyiminomethyl)ethanolamines. Effects of the configuration around the iminic double bond on the beta-adrenergic affinity of moim-type beta-adrenergic blocking agents 192
4-[6-(dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor 192
Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system 192
Hypoxia-activated lysyl oxidase (LOX) inhibitors in the treatment of highly invasive and metastatic cancer 190
CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides 190
SYNTHESIS, ANTIINFLAMMATORY ACTIVITY AND MOLECULAR-ORBITAL STUDIES OF A SERIES OF BENZYLIDENEAMINOXYPROPIONIC ACIDS SUBSTITUTED ON THE PHENYL RING 188
Estrogen receptor ligands: a patent review update 188
Conformationally Restrained Analogs of Sympathomimetic Catecholamines. Synthesis, Conformational Analysis, and Adrenergic Activity of Isochroman Derivatives 188
MolBook UNIPI─Create, Manage, Analyze, and Share Your Chemical Data for Free 187
A new D2 dopamine receptor agonist allosterically modulates A2A adenosine receptor signalling by interacting with the A2A/D2 receptor heteromer 187
A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress 187
Conformationally restrained ß-blocking oxime ethers. 2. Synthesis and ß-adrenergic properties of diastereoisomeric anti and syn 2-(5’-(3’-aryl-substituted)isoxazolidinyl)-N-alkylethanolamines 186
Highly Selective Salicylketoxime-Based Estrogen Receptor β Agonists Display Antiproliferative Activities in a Glioma Model 186
Synthesis and ß-adrenergic properties of (E)-N-[3-(alkylamino)-2- hydroxypropilidene](methyloxy)amines substituted with an aromatic group on their [(methyloxy)imino]methyl moiety (MOIMM): an investigation into the biopharmacological effects of an aryl substitution in the class of MOIM ß-blocking drugs. 185
Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells 184
Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells 184
QSAR models for predicting enzymatic hydrolysis of new chemical entities in 'soft-drug' design 183
Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes 182
Conformationally restrained beta-blocking oxime ethers: synthesis and beta-adrenergic properties of diastereoisomeric anti and syn 2-(5-isoxazolidinyl)ethanolamines 181
Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds 181
Role of the benzylic hydroxyl group of adrenergic cattecholamines in eliciting alpha-adrenergic activity. Synthesis and alpha1- and alpha2-adrenergic activity of 3-phenyl-3-piperidinols and of their desoxy analogs 180
7-Nitrobenzofurazan (NBD)-Derivatives Of 5'-N-Ethylcarboxamidoadenosine (NECA) As New Fluorescent Probes For Human A3 Adenosine Receptors 180
Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells 179
N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation 179
Selective activators of estrogen receptor beta based on the aldoxime and ketoxime scaffolds 178
2-(Methyleneaminoxy)methylmorpholine derivatives. Synthesis and antidepressant activity 178
Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands 178
3-(Methyleneaminoxy)methylpiperidine derivatives as uptake inhibitors of biogenic amines in the brain synaptosomal fraction 177
Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents 177
VenomPred 2.0: A Novel In Silico Platform for an Extended and Human Interpretable Toxicological Profiling of Small Molecules 176
Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology. 176
Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives 175
Synthesis and antimicrobial activity of 7ß-(S) and 7ß-(R)-3-(methyleneaminoxy)-2-methylpropionamido substituted cephalosporanic acid derivatives 175
New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) 175
Synthesis and adrenergic ß-blocking activity of (oxypropanolamino)-substituted [(benzylideneamino)oxy]propanolamines 175
Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells 174
Rutin content in the forage and grain of common buckwheat (Fagopyrum esculentum) as affected by sowing time and irrigation in a Mediterranean environment. 174
Antioxidant and neuroprotective activity of extra virgin olive oil extracts obtained from quercetano cultivar trees grown in different areas of the tuscany region (Italy) 174
Synthesis and aldose reductase inhibitory activity of N-(arylsulfonyl)- and N-(aroyl)-N-(arylmethyloxy)glycines 173
Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity 173
Totale 20.416
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Categoria #
all - tutte 134.676
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 134.676
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021356 0 0 0 0 0 0 0 0 0 0 0 356
2021/20223.614 99 342 93 217 563 472 136 176 132 116 204 1.064
2022/20234.384 558 598 336 374 509 569 51 333 674 32 254 96
2023/20242.610 304 275 291 114 386 495 172 65 48 57 100 303
2024/202510.225 52 379 213 592 919 959 849 586 1.002 1.336 1.152 2.186
2025/202611.505 889 1.468 1.374 961 1.033 1.069 1.733 584 727 954 490 223
Totale 49.701