DIGIACOMO, MARIA
 Distribuzione geografica
Continente #
NA - Nord America 7.648
AS - Asia 3.818
EU - Europa 3.559
SA - Sud America 527
AF - Africa 143
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 2
Totale 15.705
Nazione #
US - Stati Uniti d'America 7.396
IT - Italia 1.474
SG - Singapore 1.332
CN - Cina 1.059
HK - Hong Kong 561
SE - Svezia 457
BR - Brasile 434
DE - Germania 415
VN - Vietnam 288
BG - Bulgaria 224
CA - Canada 196
FR - Francia 178
FI - Finlandia 166
GB - Regno Unito 162
TR - Turchia 147
RU - Federazione Russa 114
AT - Austria 108
IN - India 90
JP - Giappone 85
KR - Corea 74
UA - Ucraina 54
NL - Olanda 42
PL - Polonia 40
CI - Costa d'Avorio 36
CH - Svizzera 31
AR - Argentina 30
BD - Bangladesh 26
NG - Nigeria 25
MX - Messico 24
ES - Italia 20
IQ - Iraq 20
PK - Pakistan 18
ZA - Sudafrica 18
MA - Marocco 17
BE - Belgio 16
CZ - Repubblica Ceca 16
SA - Arabia Saudita 16
UZ - Uzbekistan 13
VE - Venezuela 12
IL - Israele 11
PY - Paraguay 10
CL - Cile 9
CO - Colombia 9
EC - Ecuador 9
ID - Indonesia 9
SN - Senegal 9
GR - Grecia 8
MY - Malesia 8
AU - Australia 7
DZ - Algeria 7
IR - Iran 7
LT - Lituania 7
NP - Nepal 7
AZ - Azerbaigian 6
CR - Costa Rica 6
IE - Irlanda 6
JM - Giamaica 6
KE - Kenya 6
EG - Egitto 5
KZ - Kazakistan 5
RO - Romania 5
TT - Trinidad e Tobago 5
UY - Uruguay 5
BJ - Benin 4
BO - Bolivia 4
ET - Etiopia 4
HN - Honduras 4
PE - Perù 4
BY - Bielorussia 3
GA - Gabon 3
GE - Georgia 3
JO - Giordania 3
KH - Cambogia 3
LB - Libano 3
PH - Filippine 3
PS - Palestinian Territory 3
PT - Portogallo 3
AL - Albania 2
AM - Armenia 2
BB - Barbados 2
GH - Ghana 2
KG - Kirghizistan 2
LK - Sri Lanka 2
NI - Nicaragua 2
OM - Oman 2
PR - Porto Rico 2
SI - Slovenia 2
SV - El Salvador 2
SY - Repubblica araba siriana 2
TH - Thailandia 2
TN - Tunisia 2
TW - Taiwan 2
A1 - Anonimo 1
AE - Emirati Arabi Uniti 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BH - Bahrain 1
BS - Bahamas 1
BW - Botswana 1
CM - Camerun 1
Totale 15.691
Città #
Ashburn 881
Singapore 755
Woodbridge 585
Hong Kong 552
Fairfield 545
Serra 532
Houston 457
Dallas 430
Chandler 419
Santa Clara 408
San Jose 396
Ann Arbor 389
Beijing 234
Shanghai 230
Sofia 223
Wilmington 219
Seattle 210
Cambridge 206
Milan 166
Ottawa 150
New York 147
Princeton 115
Boardman 114
Los Angeles 104
Hefei 103
Munich 94
Vienna 93
Council Bluffs 90
Lawrence 86
Lauterbourg 85
Izmir 84
Pisa 81
Medford 80
Tokyo 77
Ho Chi Minh City 71
Seoul 66
Helsinki 63
Jacksonville 62
Nanjing 55
Buffalo 51
Des Moines 51
Frankfurt am Main 50
Istanbul 46
London 42
Dong Ket 41
Hanoi 41
Rome 40
Florence 38
Turku 37
Abidjan 36
Marseille 36
Dearborn 34
Redondo Beach 33
San Diego 33
São Paulo 33
Chicago 31
Warsaw 31
Ogden 30
Boulder 29
Tianjin 27
Lagos 25
Nanchang 25
Lucca 23
Orem 23
Redwood City 20
San Francisco 20
Pistoia 19
Pune 19
Bern 18
Columbus 18
The Dalles 18
Brussels 16
Shenyang 16
Auburn Hills 15
Brooklyn 15
Nürnberg 15
Phoenix 15
Belo Horizonte 14
Nuremberg 14
Bremen 13
Düsseldorf 13
Fuzhou 13
Brno 12
Enterprise 12
Tashkent 12
Toronto 12
Amsterdam 11
Hebei 11
Memphis 11
Salt Lake City 11
Washington 11
Zurich 11
Brasília 10
Changsha 10
Groningen 10
Guangzhou 10
Johannesburg 10
Lappeenranta 10
Livorno 10
Montreal 10
Totale 11.028
Nome #
Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells 374
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme 303
Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer 256
Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease 252
Application of An Improved HPLC-FL Method to Screen Serine Palmitoyl Transferase Inhibitors 247
Olive Mill Wastewater as Source of Polyphenols with Nutraceutical Properties 240
Diversity of yeast community composition in olive oil from two different areas in Tuscany 240
Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma 238
Synthesis and evaluation of multi-functional NO-donor/insulin-secretagogue derivatives for the treatment of type II diabetes and its cardiovascular complications 233
Identification of the first synthetic allosteric modulator of the CB2receptors and evidence of its efficacy for neuropathic pain relief 226
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system 224
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor 222
New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design,Synthesis, and Biopharmacological Properties 220
A NEW NITRIC OXIDE RELEASING ANTI-DIABETIC HYBRID DRUG: FROM THE DESIGN TO THE PHARMACOLOGICAL CHARACTERIZATION 216
In-vitro evaluation of new pharmacodynamic hybrids with insulin secretagogue and NO-donor activity 208
Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma 208
Synthesis and AT1 affinity evaluation of benzamidophenyl analogs of known AT1 receptor ligands with similar aromatic skeleton 205
The phenolic compounds tyrosol and hydroxytyrosol counteract liver fibrogenesis via the transcriptional modulation of NADPH oxidases and oxidative stress-related miRNAs 203
SAR study on arylmethyloxyphenyl scaffold: Looking for a P-gp nanomolar affinity 203
Waste autochthonous tuscan olive leaves (Olea europaea var. olivastra seggianese) as antioxidant source for biomedicine 202
Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein 201
Composition of health-promoting phenolic compounds in two extra-virgin olive oils and diversity of associated yeasts 201
Dimer of rivastigmine and caffeic acid or ferulic acid, preparation method and drug composition thereof 200
Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: Implications for drug discovery 200
The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation 200
Oxidative stress, mitochondrial abnormalities and proteins deposition: multitarget approaches in Alzheimer's disease 198
Design, synthesis and preliminary evaluation of (18)F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor 197
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 193
Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system 192
Synthesis and functional evaluation of novel aldose reductase inhibitors bearing a spirobenzopyran scaffold 189
A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress 188
Pharmacological study on the cardiovascular activity of no-sartans, pharmacodynamic hybridsexhibiting at1-antagonist and no-donor properties 186
Spirocyclic Benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel 186
ANTI-ISCHEMIC PROPERTIES OF A NEW SPIRO-CYCLIC BENZOPYRAN ACTIVATOR OF CARDIAC MITOCHONDRIAL ATP-SENSITIVE POTASSIUM CHANNELS 180
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 179
NO-Sartans: A New Class of Pharmacodynamic Hybrids as Cardiovascular Drugs 174
Antioxidant and neuroprotective activity of extra virgin olive oil extracts obtained from quercetano cultivar trees grown in different areas of the tuscany region (Italy) 174
Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel 173
Electrospun Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate)/Olive Leaf Extract Fiber Mesh as Prospective Bio-Based Scaffold for Wound Healing 170
Antiarrhythmic activity of a new spiro-cyclic benzopyran activator of the cardiac mitochondrial ATP dependent potassium channels 160
Metabolically labile cannabinoid esters: A ‘soft drug’ approach for the development of cannabinoid-based therapeutic drugs 159
Therapeutic potential of sulindac hydroxamic acid against human pancreatic and colonic cancer cells 159
Synthesis and biological evaluation of (Hetero)aryl-methyloxyphenyl derivatives as potent P-glycoprotein modulating agents. 158
Unraveling the Protective Role of Oleocanthal and Its Oxidation Product, Oleocanthalic Acid, against Neuroinflammation 156
P-gp Transporter and its Role in Neurodegenerative Diseases 156
Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD 154
In vitro investigation of sulindac derivatives as potential anticancer agents 152
NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs 149
Oleocanthalic acid from extra-virgin olive oil: Analysis, preparative isolation and radical scavenging activity 149
Synthesis of new potent P-glycoprotein inhibitors and their screening: potential tools to reduce the multidrug resistance 148
Evaluation of the NO-releasing properties of NO-donor linkers 147
miRNA Modulation and Antitumor Activity by the Extra-Virgin Olive Oil Polyphenol Oleacein in Human Melanoma Cells 147
Immunomodulatory activity of electrospun polyhydroxyalkanoate fiber scaffolds incorporating olive leaf extract 146
A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions 143
1-Phenylalkoxy-2-β-phenylethyl derivatives as P-glycoprotein (P-GP) inhibitors useful in drug resistance events 142
Synthesis and Affinity Evaluation for AT1 Receptor of Phenylsalicylaldoxime-Derivatives Structurally Related to Sartans 141
The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis 141
Novel Potent and Selective Agonists of the GPR55 Receptor Based on the 3-Benzylquinolin-2(1H)-One Scaffold 139
alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors 139
Traditional Uses of Cannabinoids and New Perspectives in the Treatment of Multiple Sclerosis 138
Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (m TAAR1) Agonists 138
Sodium N-(Methylsulfonyl)-N-(4-nitro- 2-phenoxyphenyl)sulfamate: A Water-Soluble Nimesulide Prodrug for Parenteral Use 136
Content Variations in Oleocanthalic Acid and Other Phenolic Compounds in Extra-Virgin Olive Oil during Storage 135
Synthesis and Biological Evaluation of (Hetero)Arylmethyloxy- and Arylmethylamine-phenyl Derivatives as Potent P-glycoprotein Modulating Agents 134
Synthesis and Biological Evaluation of 2'-Oxo-2,3-dihydro-3'H-spiro[chromene-4,5'-[1,3]oxazolidin]3'il]acetic Acid Derivatives as Aldose reductase Inhibitors 134
null 132
The Extra Virgin Olive Oil Polyphenol Oleocanthal Exerts Antifibrotic Effects in the Liver 132
1-Acetoxypinoresinol, a Lignan from Olives: Insight into Its Characterization, Identification, and Nutraceutical Properties 131
In-vitro evaluation of new pharmacodynamic hybrids with insulin secretagogue and NO-donor activity 130
Pharmacodynamic hybrids with insulin secretagogue and NO-Donor activity 130
Enhanced Nutraceutical Properties of Extra Virgin Olive Oil Extract by Olive Leaf Enrichment 129
PSNCBAM-1 analogs: Structural evolutions and allosteric properties at cannabinoid CB1 receptor 129
Pharmacodynamic hybrids with insulin secretagogue and NO-Donor activity 128
Enantioselectivity in Cardioprotection induced by (S)- (-)-2,2-Dimethyl-N-(4'-acetamido-benzyl)-4-spiromorpholone-chromane 128
Comparative Analysis on Polyphenolic Composition of Different Olive Mill Wastewater and Related Extra Virgin Olive Oil Extracts and Evaluation of Nutraceutical Properties by Cell-Based Studies 127
Insights into the Antioxidant/Antiradical Effects and In Vitro Intestinal Permeation of Oleocanthal and Its Metabolites Tyrosol and Oleocanthalic Acid 125
SYNTHESIS AND BIOLOGICAL EVALUATION OF 5-MEMBERED SPIRO HETEROCYCLE-BENZIPYRAN DERIVATIVES AGAINST MYOCARDIAL ISCHEMIA 123
Predictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers 118
Synthesis and biological evaluation of new compounds as cannabinoid receptor type 1 allosteric modulators 117
Phenolic Compounds in Prevention and Treatment of Skin Cancers: a review 117
Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease 113
NOVEL DIARYL UREA DERIVATIVES AS CANNABINOID TYPE 1 RECEPTOR ALLOSTERIC MODULATORS 106
Fast, sensitive, and sustainable colorimetric detection of chlorogenic acid in artichoke waste material 105
Nitric Oxide Releasing and Hypoglycaemic Properties of a Glibenclamde-Related Pharmacodynamic Hybrid 104
Spiro-benzopyran structure: a new scaffold for cardioprotection 103
A NOVEL NITRIC OXIDE RELEASING ANTI-DIABETIC DUAL DRUG: FROM THE DESIGN TO THE CHARACTERIZATION OF THE PHARMACOLOGICAL PROFILE 102
Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition 102
Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor 97
Synthesis and pharmacological activity of new nitric-oxide-donating antihypertensive drugs (NO-Sartans) 96
IDENTIFICATION OF NEW PSNCBAM-1 DERIVATIVES AS CB1 RECEPTOR ALLOSTERIC MODULATORS 96
Synthesis and biological evaluation of sulindac derivatives as potential anticancer agents 90
NO-sartans: new class of potential cardiovascular drugs 90
alpha-Naphtylaminopropan-2-ol derivatives as BACE1 inhibitors 87
NO-sartans: new class of potential cardiovascular drugs 85
BACE-1 inhibitory activities of new substituted diphenyl-methylenyl-piperazines 82
null 82
Dietary Bioactive Compounds: Implications for Oxidative Stress and Inflammation 80
Synthesis and biological evaluation of arylmethyloxy and heteroarylmethyloxy derivates as potent P-gp modulating agents 78
New pharmacodynamic hybrids endowed of insuline secretagogue and NO-donor activities 73
"Soft Drugs" Based on Cannabinoid Receptor Ligands as Potential Local Analgesic and Antiglaucoma Agents 72
Totale 15.840
Categoria #
all - tutte 45.015
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 45.015


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.102 32 138 37 58 158 144 46 52 31 21 68 317
2022/20231.477 180 201 127 120 171 182 6 103 255 8 79 45
2023/2024915 97 110 116 45 142 144 62 14 18 16 50 101
2024/20253.303 18 133 88 190 312 318 300 183 346 449 380 586
2025/20264.068 284 485 480 325 402 396 618 200 290 345 148 95
2026/202736 36 0 0 0 0 0 0 0 0 0 0 0
Totale 16.064