DIGIACOMO, MARIA
 Distribuzione geografica
Continente #
NA - Nord America 5.708
EU - Europa 2.950
AS - Asia 1.768
SA - Sud America 257
AF - Africa 83
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 2
Totale 10.776
Nazione #
US - Stati Uniti d'America 5.538
IT - Italia 1.331
CN - Cina 653
SG - Singapore 601
SE - Svezia 451
DE - Germania 314
BR - Brasile 235
BG - Bulgaria 223
CA - Canada 165
HK - Hong Kong 159
TR - Turchia 137
RU - Federazione Russa 109
GB - Regno Unito 108
AT - Austria 104
VN - Vietnam 99
FI - Finlandia 78
FR - Francia 75
UA - Ucraina 47
IN - India 45
CI - Costa d'Avorio 36
NG - Nigeria 23
CH - Svizzera 21
PL - Polonia 18
BE - Belgio 16
CZ - Repubblica Ceca 14
JP - Giappone 14
NL - Olanda 13
IL - Israele 8
SN - Senegal 8
AR - Argentina 7
AU - Australia 7
IR - Iran 6
PK - Pakistan 6
UZ - Uzbekistan 6
GR - Grecia 5
KR - Corea 5
RO - Romania 5
AZ - Azerbaigian 4
BJ - Benin 4
EC - Ecuador 4
ES - Italia 4
IE - Irlanda 4
IQ - Iraq 4
BD - Bangladesh 3
DZ - Algeria 3
KZ - Kazakistan 3
LT - Lituania 3
MA - Marocco 3
MX - Messico 3
SA - Arabia Saudita 3
UY - Uruguay 3
VE - Venezuela 3
CO - Colombia 2
GA - Gabon 2
KE - Kenya 2
LK - Sri Lanka 2
PS - Palestinian Territory 2
A1 - Anonimo 1
AL - Albania 1
AM - Armenia 1
BH - Bahrain 1
BY - Bielorussia 1
CL - Cile 1
DK - Danimarca 1
EU - Europa 1
GE - Georgia 1
JM - Giamaica 1
KG - Kirghizistan 1
LB - Libano 1
LI - Liechtenstein 1
MM - Myanmar 1
NP - Nepal 1
NZ - Nuova Zelanda 1
PE - Perù 1
PT - Portogallo 1
PY - Paraguay 1
SI - Slovenia 1
SK - Slovacchia (Repubblica Slovacca) 1
SV - El Salvador 1
TH - Thailandia 1
TN - Tunisia 1
ZA - Sudafrica 1
Totale 10.776
Città #
Woodbridge 585
Ashburn 554
Fairfield 545
Serra 532
Houston 450
Chandler 419
Ann Arbor 389
Santa Clara 388
Singapore 273
Shanghai 226
Sofia 223
Wilmington 219
Seattle 205
Cambridge 203
Milan 163
Hong Kong 158
Ottawa 149
Beijing 147
Princeton 115
New York 112
Boardman 105
Vienna 91
Lawrence 86
Izmir 83
Medford 80
Pisa 66
Jacksonville 61
Nanjing 54
Des Moines 50
Istanbul 44
Dong Ket 41
Florence 38
Abidjan 36
Frankfurt am Main 36
Dearborn 34
Marseille 34
San Diego 33
London 32
Ogden 30
Boulder 29
Rome 29
Nanchang 25
Lagos 23
Los Angeles 23
Lucca 22
Redwood City 20
Pistoia 19
Bern 18
Dallas 17
Hefei 17
Pune 17
Brussels 16
São Paulo 16
Auburn Hills 15
Nürnberg 15
Shenyang 15
Chicago 14
Belo Horizonte 13
Bremen 13
Düsseldorf 13
Fuzhou 13
Helsinki 13
Brno 12
Buffalo 12
Enterprise 12
Munich 12
Warsaw 12
Hebei 11
Nuremberg 11
San Francisco 11
The Dalles 11
Livorno 10
Tianjin 10
Washington 10
Jüchen 9
Norwalk 9
Quanzhou 9
Toronto 9
Changsha 8
Chengdu 8
Council Bluffs 8
Dakar 8
Falkenstein 8
Cascina 7
San Giuliano Terme 7
Tokyo 7
Favria 6
Hangzhou 6
Jiaxing 6
Kunming 6
Lancaster 6
Lauterbourg 6
Morgantown 6
Phoenix 6
Porto Azzurro 6
Salt Lake City 6
Tashkent 6
Albenga 5
Berlin 5
Brasília 5
Totale 7.816
Nome #
Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells 289
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme 235
Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma 186
Synthesis and evaluation of multi-functional NO-donor/insulin-secretagogue derivatives for the treatment of type II diabetes and its cardiovascular complications 185
Diversity of yeast community composition in olive oil from two different areas in Tuscany 185
Application of An Improved HPLC-FL Method to Screen Serine Palmitoyl Transferase Inhibitors 181
Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer 180
New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design,Synthesis, and Biopharmacological Properties 179
A NEW NITRIC OXIDE RELEASING ANTI-DIABETIC HYBRID DRUG: FROM THE DESIGN TO THE PHARMACOLOGICAL CHARACTERIZATION 177
Identification of the first synthetic allosteric modulator of the CB2receptors and evidence of its efficacy for neuropathic pain relief 175
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system 173
Design, synthesis and preliminary evaluation of (18)F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor 172
Synthesis and AT1 affinity evaluation of benzamidophenyl analogs of known AT1 receptor ligands with similar aromatic skeleton 165
Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma 164
Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein 161
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor 159
Composition of health-promoting phenolic compounds in two extra-virgin olive oils and diversity of associated yeasts 156
ANTI-ISCHEMIC PROPERTIES OF A NEW SPIRO-CYCLIC BENZOPYRAN ACTIVATOR OF CARDIAC MITOCHONDRIAL ATP-SENSITIVE POTASSIUM CHANNELS 152
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 152
Dimer of rivastigmine and caffeic acid or ferulic acid, preparation method and drug composition thereof 152
In-vitro evaluation of new pharmacodynamic hybrids with insulin secretagogue and NO-donor activity 151
Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel 151
SAR study on arylmethyloxyphenyl scaffold: Looking for a P-gp nanomolar affinity 150
Pharmacological study on the cardiovascular activity of no-sartans, pharmacodynamic hybridsexhibiting at1-antagonist and no-donor properties 149
NO-Sartans: A New Class of Pharmacodynamic Hybrids as Cardiovascular Drugs 149
Antiarrhythmic activity of a new spiro-cyclic benzopyran activator of the cardiac mitochondrial ATP dependent potassium channels 145
Synthesis and functional evaluation of novel aldose reductase inhibitors bearing a spirobenzopyran scaffold 145
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 143
Spirocyclic Benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel 142
The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation 142
Waste autochthonous tuscan olive leaves (Olea europaea var. olivastra seggianese) as antioxidant source for biomedicine 139
Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease 139
Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: Implications for drug discovery 137
Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system 137
Metabolically labile cannabinoid esters: A ‘soft drug’ approach for the development of cannabinoid-based therapeutic drugs 136
P-gp Transporter and its Role in Neurodegenerative Diseases 134
null 132
Oxidative stress, mitochondrial abnormalities and proteins deposition: multitarget approaches in Alzheimer's disease 132
A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress 131
Therapeutic potential of sulindac hydroxamic acid against human pancreatic and colonic cancer cells 127
Evaluation of the NO-releasing properties of NO-donor linkers 127
Synthesis and Affinity Evaluation for AT1 Receptor of Phenylsalicylaldoxime-Derivatives Structurally Related to Sartans 119
NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs 119
alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors 117
Synthesis and Biological Evaluation of (Hetero)Arylmethyloxy- and Arylmethylamine-phenyl Derivatives as Potent P-glycoprotein Modulating Agents 115
1-Phenylalkoxy-2-β-phenylethyl derivatives as P-glycoprotein (P-GP) inhibitors useful in drug resistance events 115
Synthesis and biological evaluation of (Hetero)aryl-methyloxyphenyl derivatives as potent P-glycoprotein modulating agents. 115
Synthesis of new potent P-glycoprotein inhibitors and their screening: potential tools to reduce the multidrug resistance 114
Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD 114
A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions 113
The phenolic compounds tyrosol and hydroxytyrosol counteract liver fibrogenesis via the transcriptional modulation of NADPH oxidases and oxidative stress-related miRNAs 111
Sodium N-(Methylsulfonyl)-N-(4-nitro- 2-phenoxyphenyl)sulfamate: A Water-Soluble Nimesulide Prodrug for Parenteral Use 108
In vitro investigation of sulindac derivatives as potential anticancer agents 107
In-vitro evaluation of new pharmacodynamic hybrids with insulin secretagogue and NO-donor activity 106
Enantioselectivity in Cardioprotection induced by (S)- (-)-2,2-Dimethyl-N-(4'-acetamido-benzyl)-4-spiromorpholone-chromane 104
Traditional Uses of Cannabinoids and New Perspectives in the Treatment of Multiple Sclerosis 103
SYNTHESIS AND BIOLOGICAL EVALUATION OF 5-MEMBERED SPIRO HETEROCYCLE-BENZIPYRAN DERIVATIVES AGAINST MYOCARDIAL ISCHEMIA 102
Pharmacodynamic hybrids with insulin secretagogue and NO-Donor activity 94
miRNA Modulation and Antitumor Activity by the Extra-Virgin Olive Oil Polyphenol Oleacein in Human Melanoma Cells 94
Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition 93
Predictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers 92
Oleocanthalic acid from extra-virgin olive oil: Analysis, preparative isolation and radical scavenging activity 91
Synthesis and Biological Evaluation of 2'-Oxo-2,3-dihydro-3'H-spiro[chromene-4,5'-[1,3]oxazolidin]3'il]acetic Acid Derivatives as Aldose reductase Inhibitors 90
Antioxidant and neuroprotective activity of extra virgin olive oil extracts obtained from quercetano cultivar trees grown in different areas of the tuscany region (Italy) 90
Pharmacodynamic hybrids with insulin secretagogue and NO-Donor activity 86
The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis 83
null 82
PSNCBAM-1 analogs: Structural evolutions and allosteric properties at cannabinoid CB1 receptor 80
Immunomodulatory activity of electrospun polyhydroxyalkanoate fiber scaffolds incorporating olive leaf extract 79
Phenolic Compounds in Prevention and Treatment of Skin Cancers: a review 78
Content Variations in Oleocanthalic Acid and Other Phenolic Compounds in Extra-Virgin Olive Oil during Storage 77
The Extra Virgin Olive Oil Polyphenol Oleocanthal Exerts Antifibrotic Effects in the Liver 76
Nitric Oxide Releasing and Hypoglycaemic Properties of a Glibenclamde-Related Pharmacodynamic Hybrid 73
A NOVEL NITRIC OXIDE RELEASING ANTI-DIABETIC DUAL DRUG: FROM THE DESIGN TO THE CHARACTERIZATION OF THE PHARMACOLOGICAL PROFILE 73
NO-sartans: new class of potential cardiovascular drugs 72
Electrospun Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate)/Olive Leaf Extract Fiber Mesh as Prospective Bio-Based Scaffold for Wound Healing 69
Synthesis and biological evaluation of sulindac derivatives as potential anticancer agents 69
Spiro-benzopyran structure: a new scaffold for cardioprotection 69
Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (m TAAR1) Agonists 67
Synthesis and pharmacological activity of new nitric-oxide-donating antihypertensive drugs (NO-Sartans) 66
Olive Mill Wastewater as Source of Polyphenols with Nutraceutical Properties 64
alpha-Naphtylaminopropan-2-ol derivatives as BACE1 inhibitors 64
null 63
IDENTIFICATION OF NEW PSNCBAM-1 DERIVATIVES AS CB1 RECEPTOR ALLOSTERIC MODULATORS 62
Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease 61
NOVEL DIARYL UREA DERIVATIVES AS CANNABINOID TYPE 1 RECEPTOR ALLOSTERIC MODULATORS 60
NO-sartans: new class of potential cardiovascular drugs 57
BACE-1 inhibitory activities of new substituted diphenyl-methylenyl-piperazines 57
Synthesis and biological evaluation of new compounds as cannabinoid receptor type 1 allosteric modulators 57
Novel Potent and Selective Agonists of the GPR55 Receptor Based on the 3-Benzylquinolin-2(1H)-One Scaffold 56
New pharmacodynamic hybrids endowed of insuline secretagogue and NO-donor activities 55
Synthesis and biological evaluation of arylmethyloxy and heteroarylmethyloxy derivates as potent P-gp modulating agents 54
"Soft Drugs" Based on Cannabinoid Receptor Ligands as Potential Local Analgesic and Antiglaucoma Agents 54
Enhanced Nutraceutical Properties of Extra Virgin Olive Oil Extract by Olive Leaf Enrichment 46
Insights into the Antioxidant/Antiradical Effects and In Vitro Intestinal Permeation of Oleocanthal and Its Metabolites Tyrosol and Oleocanthalic Acid 34
Dietary Bioactive Compounds: Implications for Oxidative Stress and Inflammation 32
1-Acetoxypinoresinol, a Lignan from Olives: Insight into Its Characterization, Identification, and Nutraceutical Properties 29
Unraveling the Protective Role of Oleocanthal and Its Oxidation Product, Oleocanthalic Acid, against Neuroinflammation 24
Fast, sensitive, and sustainable colorimetric detection of chlorogenic acid in artichoke waste material 20
Comparative Analysis on Polyphenolic Composition of Different Olive Mill Wastewater and Related Extra Virgin Olive Oil Extracts and Evaluation of Nutraceutical Properties by Cell-Based Studies 19
Totale 11.109
Categoria #
all - tutte 31.654
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 31.654


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020173 0 0 0 0 0 0 0 0 0 0 135 38
2020/2021911 60 42 79 68 69 49 88 73 130 81 49 123
2021/20221.102 32 138 37 58 158 144 46 52 31 21 68 317
2022/20231.477 180 201 127 120 171 182 6 103 255 8 79 45
2023/2024915 97 110 116 45 142 144 62 14 18 16 50 101
2024/20252.466 18 133 88 190 312 318 300 183 346 449 129 0
Totale 11.123