COSTA, BARBARA
 Distribuzione geografica
Continente #
NA - Nord America 13.531
EU - Europa 5.761
AS - Asia 5.758
SA - Sud America 781
AF - Africa 263
OC - Oceania 55
Continente sconosciuto - Info sul continente non disponibili 5
Totale 26.154
Nazione #
US - Stati Uniti d'America 13.080
IT - Italia 2.299
SG - Singapore 1.821
CN - Cina 1.765
HK - Hong Kong 943
DE - Germania 796
SE - Svezia 736
BR - Brasile 676
BG - Bulgaria 436
CA - Canada 354
TR - Turchia 339
GB - Regno Unito 333
VN - Vietnam 244
RU - Federazione Russa 226
FI - Finlandia 211
UA - Ucraina 180
IN - India 155
KR - Corea 137
AT - Austria 135
FR - Francia 129
JP - Giappone 65
CI - Costa d'Avorio 60
BE - Belgio 52
AU - Australia 50
BD - Bangladesh 45
SN - Senegal 43
CH - Svizzera 42
MX - Messico 42
NL - Olanda 42
IQ - Iraq 41
ZA - Sudafrica 40
NG - Nigeria 37
PL - Polonia 32
AR - Argentina 30
ES - Italia 28
PK - Pakistan 28
SA - Arabia Saudita 24
GR - Grecia 23
ID - Indonesia 21
MA - Marocco 19
EC - Ecuador 16
CO - Colombia 15
JO - Giordania 15
VE - Venezuela 15
KE - Kenya 13
UZ - Uzbekistan 13
EG - Egitto 12
AE - Emirati Arabi Uniti 11
AZ - Azerbaigian 11
JM - Giamaica 11
TT - Trinidad e Tobago 11
IE - Irlanda 10
CZ - Repubblica Ceca 9
IL - Israele 9
OM - Oman 9
DZ - Algeria 8
PY - Paraguay 8
BJ - Benin 7
IR - Iran 7
LT - Lituania 7
CL - Cile 6
ET - Etiopia 6
MY - Malesia 6
NP - Nepal 6
PE - Perù 6
DK - Danimarca 5
HU - Ungheria 5
LB - Libano 5
NZ - Nuova Zelanda 5
PA - Panama 5
PH - Filippine 5
RO - Romania 5
TW - Taiwan 5
BB - Barbados 4
CR - Costa Rica 4
EU - Europa 4
GT - Guatemala 4
HN - Honduras 4
KG - Kirghizistan 4
KZ - Kazakistan 4
TN - Tunisia 4
UY - Uruguay 4
EE - Estonia 3
GE - Georgia 3
NI - Nicaragua 3
PS - Palestinian Territory 3
PT - Portogallo 3
AL - Albania 2
AM - Armenia 2
BH - Bahrain 2
BO - Bolivia 2
DO - Repubblica Dominicana 2
GH - Ghana 2
GY - Guiana 2
HR - Croazia 2
KW - Kuwait 2
LV - Lettonia 2
MD - Moldavia 2
PR - Porto Rico 2
QA - Qatar 2
Totale 26.123
Città #
Woodbridge 1.598
Ann Arbor 1.276
Ashburn 1.250
Houston 1.062
Singapore 990
Hong Kong 936
Serra 926
Fairfield 890
Chandler 865
Santa Clara 668
Dallas 633
Sofia 436
Shanghai 369
Beijing 353
Milan 346
New York 336
Wilmington 327
Seattle 326
Ottawa 288
Cambridge 253
San Jose 240
Izmir 230
Boardman 218
Los Angeles 214
Princeton 202
Jacksonville 196
Lawrence 172
Hefei 163
Nanjing 156
Medford 148
Des Moines 134
Seoul 127
Vienna 120
Frankfurt am Main 118
Dong Ket 98
London 91
Chicago 85
Istanbul 83
Pisa 81
Dearborn 74
Florence 66
Buffalo 65
Munich 65
São Paulo 65
Redondo Beach 62
Abidjan 60
Council Bluffs 52
Tokyo 52
Nanchang 51
Brussels 49
Rome 48
The Dalles 48
Dakar 43
San Diego 43
Columbus 42
Bremen 39
Ogden 39
Sydney 39
Bern 37
Lagos 35
Redwood City 35
Helsinki 33
Nürnberg 33
Rho 33
Kunming 32
Pistoia 32
Boulder 31
Changsha 31
Ho Chi Minh City 31
Lancaster 31
Jüchen 29
Falls Church 28
Shenyang 28
Guangzhou 27
Jiaxing 26
Livorno 26
Turku 26
Norwalk 25
Lucca 24
Auburn Hills 23
Belo Horizonte 23
Paris 23
Warsaw 23
Hebei 22
Brasília 21
Pune 21
Asnières-sur-Seine 20
Düsseldorf 20
Santa Margherita Ligure 20
Johannesburg 19
Rio de Janeiro 19
Tianjin 19
Toronto 19
Hangzhou 18
Nuremberg 18
Fuzhou 17
San Francisco 17
Hanoi 16
Phoenix 16
Amman 15
Totale 19.048
Nome #
TSPO ligand residence time influences human glioblastoma multiforme cell death/life balance 322
Ala147Thr amino acid substitution within the translocator protein (TSPO) influences pregnenolone production in lymphomonocytes 304
AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells 293
N, N-Dialkyl-2-phenylindol-3-ylglyoxylamides.A new class of potent and selective ligands at the Peripheral benzodiazepine receptor 275
IL POLIMORFISMO ALA147THR ALL’INTERNO DEL TRASLOCATORE PROTEICO (TSPO) INFLUENZA LA PRODUZIONE DI PREGNENOLONE NEI LINFO-MONOCITI DI SOGGETTI SANI 268
Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma 261
A (2A) ADENOSINE RECEPTOR LIGANDS AND PROINFLAMMATORY CYTOKINES INDUCE PC12 CELL DEATH THROUGH APOPTOSIS 244
The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage 242
null 236
Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells 234
An antibody-free strategy for screening putative HDM2 inhibitors using crude bacterial lysates expressing GST-HDM2 recombinant protein 228
Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells 217
TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis 213
TSPO PIGA ligands promote neurosteroidogenesis and human astrocyte well-being 211
Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors 207
Bifunctional Inhibitors as a New Tool To Reduce Cancer Cell Invasion by Impairing MMP-9 Homodimerization 205
An update into the medicinal chemistry of translocator protein (TSPO) ligands 203
Oxytocin receptor and G-protein polymorphisms in patients with depression and separation anxiety 200
Oxytocin receptor gene variation, behavioural inhibition, and adult separation anxiety: role in complicated grief 200
TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy 200
Analysis of the Antitumor Activity of Clotrimazole on A375 Human Melanoma Cells 199
TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells 199
Identification of Anxiolytic/Nonsedative Agents among Indol-3-ylglyoxylamides Acting as Functionally Selective Agonists at the γ-Aminobutyric Acid-A (GABAA) α2 Benzodiazepine Receptor 198
Long Residence Time at the Neurosteroidogenic 18 kDa Translocator Protein Characterizes the Anxiolytic Ligand XBD173 196
Benzodiazepine receptor ligands. 8: Synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: High affinity ligands endowed with inverse-agonist pharmacological efficacy 189
5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species 189
Drug-target Residence Time: a key parameter in glial responses to TSPO ligands 187
Attivazione di segnali per l'induzione dell'apoptosi e/o per la sopravvivenza cellulare da parte di ligandi selettivi per il recettore periferico delle benzodiazepine 186
Ala147Thrsubstitution in translocator protein is associated with adult separation anxiety in patients with depression 186
Translocator protein as a promising target for novel anxiolytics 186
Epigenetic Modifications of the α-Synuclein Gene and Relative Protein Content Are Affected by Ageing and Physical Exercise in Blood from Healthy Subjects 184
Residence Time (RT), a new parameter to predict neurosteroidogenic efficacy of Translocator Protein (TSPO) ligands: N,N-dialkyl-2-arylindol-3-ylglyoxylamides, a case study 184
Evaluation of 2,3,4,8,13a hexahydro-1H-benzo[5,6]cyclohepta-6,7-dihydroxy[1,2,3-ef][3]benzazepine derivatives as dopamine receptor ligands 183
The Spontaneous Ala147Thr Amino Acid Substitution within the Translocator Protein Influences Pregnenolone Production in Lymphomonocytes of Healthy Individuals 183
Studies in search for selective ligands for GABAA/BzR receptor subtypes: synthesis and biological evaluation of 4'-modified N-(benzyl)indol-3-ylglyoxylamides 182
Negative effects of a high tumour necrosis factor-α concentration on human gingival mesenchymal stem cell trophism: The use of natural compounds as modulatory agents 178
Translocator Protein (TSPO) and Neurosteroids: Implications in Psychiatric Disorders. 176
2,9-Disubstituted-N6-(arylcarbamoyl)-8-azaadenines as new selective A3 adenosine receptor antagonists: Synthesis, biochemical and molecular modelling studies 176
Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor 175
Role of Translocator Protein (18 kDa) in Adult Separation Anxiety and Attachment Style in Patients with Depression. 175
Targeting the 18-kDa translocator protein: Recent perspectives for neuroprotection 173
The Anxiolytic Etifoxine Binds to TSPO Ro5-4864 Binding Site with Long Residence Time Showing a High Neurosteroidogenic Activity 170
Reductions in platelet 18-kDa translocator protein density are associated with adult separation anxiety in patients with bipolar disorder 168
Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells 166
Translocator protein (tspo) ligand residence time: a new parameter to predict neurosteroidogenic efficacy for n,n-dialkyl-2-arylindol-3-ylglyoxylamides (PIGAs) 164
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors 164
2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands 163
Synthesis and Biological Evaluation of 4-Phenylquinazoline-2-carboxamides Designed as a Novel Class of Potent Ligands of the Translocator Protein 162
Chemical modification of the dihydropyridines binding sites by lysine reagent, pyridoxal 5’-phosphate 162
Antitumoral effect by induction of collapse of mitochondrial membrane potential in Glioblastoma Multiforme cells 161
Serotonin: a signaling molecule during embryonal development of the amphibian Xenopus laevis 161
Benzodiazepine receptor ligands. 7. Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) derivative: an anxioselective agent in rodents 161
DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization 160
C-Nucleoside analogues of furanfurin as ligands to A1 adenosine receptors 160
Anxiolytic properties of a 2-phenylindolglyoxylamide TSPO ligand: Stimulation of in vitro neurosteroid production affecting GABA(A) receptor activity 160
A2A adenosine receptor: solubilization from bovine striatal membranes by digitonin detergent. 159
2,3-butanedione inactivates the [H-3]nitrendipine binding sites, whereas diethylpyrocarbonate does not 157
An irreversible ligand of the 18 kDa Translocator Protein induces rapidly ΔΨm collapse and activates apoptosis in human glioblastoma multiforme cells. 157
Characterization of a voltage-dependent L-type calcium channel from rabbit and turtle brain 156
Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein 156
Oxytocin receptor polymorphisms and adult attachment style in patients with depression 156
Exploiting the 4-Phenylquinazoline Scaffold for the Development of High Affinity Fluorescent Probes for the Translocator Protein (TSPO) 156
PIGA (N,N-Di-n-butyl-5-chloro-2-(4-chlorophenyl)indol-3-ylglyoxylamide), a new mitochondrial benzodiazepine-receptor ligand, induces apoptosis in C6 glioma cells 155
The human microglial surveillant phenotype is preserved by de novo neurosteroidogenesis through the control of cholesterol homeostasis: Crucial role of 18 kDa Translocator Protein 153
PK 11195 differentially affects cell survival in human wild-type and 18 kDa translocator protein-silenced ADF astrocytoma cells 153
Bioisosterism, enantioselectivity and molecular modeling of new effective N6- and/or N(9)-substituted 2-phenyl adenines and 8-aza analogs: different binding modes to A1 adenosine receptors 151
Relazione tra densità del recttore periferico delle benzodiazepine (PBR) e tumorogenicità delle cellule di glioma: produzione di linee cellulari ingegnerizzate a sovraesprimere il PBR 151
N,N-Dialkyl-2-phenylindol-3- ylglyoxylamides. A New Class of Potent and Selective Ligands at the Peripheral Benzodiazepine Receptor 151
Oxytocin receptor polymorphisms and adult attachment style in patients with depression 151
18-kDa translocator protein association complexes in the brain: From structure to function 151
Carbonic anhydrase activation profile of indole-based derivatives 151
Characterization of a cloned xenopus laevis serotonin 5-HT1A receptor expressed in the NIH-3T3 cell line. 150
Benzodiazepine receptor ligands-Part II. Synthesis and biological evaluation of pyrazolo[5,1-c][1,2,4]benzotriazine 4-oxide 150
A2a Adenosine Receptors: guanine nucleotide derivative regulation in porcine striatal membranes and digitonin soluble fraction 149
ERYTHRO AND THREO 2-HYDROXYNONYL SUBSTITUTED 2-PHENYLADENINES AND 2-PHENYL-8-AZAADENINES: LIGANDS FOR A1 ADENOSINE RECEPTORS AND ADENOSINE DEAMINASE 149
Translocator protein and steroidogenesis 149
Translocator protein (TSPO) and identification of new molecular diagnosis tools 148
Mutation analysis of oxytocin gene in individuals with adult separation anxiety 148
A2A adenosine receptors and cytokines: modulation of apoptosis in PC12 cells 147
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists 147
Powerful twin carboxylic inhibitors for MMP homodimerization 146
Microglial pro-inflammatory and anti-inflammatory phenotypes are modulated by translocator protein activation 146
The peripheral-type benzodiazepine receptor ligand PK 11195 induces mitochondrial permeability transition and apoptosis in human healthy lymphocytes 145
Inhibition of metalloproteinases derived from tumours: new insights in the treatment of human glioblastoma 145
Functional expression of the Xenopus laevis 5-hydroxytryptamine1A receptor gene in NIH3T3 cells 144
Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: synthesis, biological evaluation and 3D-QSAR investigation 144
The relationship of separation anxiety with the age of onset of panic disorder 142
C825T Polymorphism of the G- protein beta 3 gene in patients with panic disorder 142
Synthesis and BZR affinity of pyrazolo[1,5-a]pyrimidine derivatives. Part 1: study of the structural features for BZR recognition 141
A 2-phenylindol-3-ylglyoxylammide derivative, a new-synthesized peripheral benzodiazepine receptor ligand, induces apoptosis in rat C6 glioma cells 140
Structure-Activity Relationship Refinement and Further Assessment of 4-Phenylquinazoline-2-carboxamide Translocator Protein Ligands as Antiproliferative Agents in Human Glioblastoma Tumors. 140
The role of serotonin in the Xenopus laevis embryos development. 139
Synthesis and benzodiazepine receptor binding activity of 2, 9-disubstituted quinolino[2', 3'-5, 4](3-pyrazolino)[3, 2-b]purin-4-ones 139
C825T POLYMORPHISM OF G-PROTEIN BETA3 GENE INPATIENTS WITH DSM-IV PANIC DISORDER 138
Serotonin: a signalling molecule during embryonal development of the amphibian Xenopus laevis 138
pyrazolo [1,5-a]pyrimidines: new peripheral benzodiazepine receptor ligands 138
Peripheral type benzodiazepine receptor in human parathyroid glands: up-regulation in adenoma 138
Synthesis of Novel 4-Aryl-1,2,3,4-tetrahydroisoquinolines as Probes for Dopamine Receptor Ligands. 138
De novo neurosteroidogenesis in human microglia: Involvement of the 18 kda translocator protein 136
Compounds with a benzo [a]carbazole structure for use in the prevention and/or treatment of infectious diseases 135
Totale 17.544
Categoria #
all - tutte 70.521
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 70.521


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021803 0 0 0 0 0 0 61 140 202 123 85 192
2021/20222.006 44 205 85 101 341 259 83 92 52 37 114 593
2022/20232.673 323 301 162 286 310 356 22 230 469 11 167 36
2023/20241.881 195 181 199 105 248 336 60 97 34 76 104 246
2024/20255.561 52 219 54 322 538 575 355 280 594 769 587 1.216
2025/20263.889 507 764 750 379 616 609 264 0 0 0 0 0
Totale 26.501