MINUTOLO, FILIPPO
 Distribuzione geografica
Continente #
NA - Nord America 21.485
AS - Asia 10.544
EU - Europa 10.133
SA - Sud America 1.455
AF - Africa 403
OC - Oceania 40
Continente sconosciuto - Info sul continente non disponibili 6
Totale 44.066
Nazione #
US - Stati Uniti d'America 20.741
IT - Italia 4.444
SG - Singapore 3.234
CN - Cina 2.903
HK - Hong Kong 1.600
BR - Brasile 1.230
SE - Svezia 1.152
DE - Germania 1.005
VN - Vietnam 831
BG - Bulgaria 726
CA - Canada 599
TR - Turchia 594
FR - Francia 569
GB - Regno Unito 495
FI - Finlandia 433
IN - India 360
RU - Federazione Russa 335
UA - Ucraina 318
JP - Giappone 263
KR - Corea 196
CH - Svizzera 145
AT - Austria 108
BD - Bangladesh 86
NL - Olanda 84
BE - Belgio 77
CI - Costa d'Avorio 71
NG - Nigeria 71
AR - Argentina 67
MX - Messico 65
IQ - Iraq 56
PL - Polonia 56
ZA - Sudafrica 54
ES - Italia 49
MA - Marocco 44
ID - Indonesia 43
SA - Arabia Saudita 42
PK - Pakistan 39
EC - Ecuador 37
UZ - Uzbekistan 36
AU - Australia 32
SN - Senegal 31
VE - Venezuela 31
CO - Colombia 29
IR - Iran 25
EG - Egitto 23
IL - Israele 21
KE - Kenya 21
TN - Tunisia 20
CL - Cile 19
JO - Giordania 19
TW - Taiwan 18
IE - Irlanda 17
NP - Nepal 17
CZ - Repubblica Ceca 16
MY - Malesia 16
AZ - Azerbaigian 15
GR - Grecia 15
PY - Paraguay 15
RO - Romania 15
PH - Filippine 14
AE - Emirati Arabi Uniti 13
DO - Repubblica Dominicana 13
OM - Oman 13
DK - Danimarca 12
DZ - Algeria 12
JM - Giamaica 12
KZ - Kazakistan 12
TT - Trinidad e Tobago 12
GH - Ghana 11
LT - Lituania 11
MO - Macao, regione amministrativa speciale della Cina 11
UY - Uruguay 11
CR - Costa Rica 10
BJ - Benin 9
HU - Ungheria 9
PE - Perù 9
TH - Thailandia 9
BY - Bielorussia 8
ET - Etiopia 8
NZ - Nuova Zelanda 8
AL - Albania 6
AO - Angola 6
BA - Bosnia-Erzegovina 6
LB - Libano 6
LK - Sri Lanka 6
PA - Panama 6
PS - Palestinian Territory 6
BB - Barbados 5
HN - Honduras 5
RS - Serbia 5
AM - Armenia 4
BO - Bolivia 4
GE - Georgia 4
LA - Repubblica Popolare Democratica del Laos 4
PT - Portogallo 4
QA - Qatar 4
SY - Repubblica araba siriana 4
BH - Bahrain 3
BN - Brunei Darussalam 3
CU - Cuba 3
Totale 43.994
Città #
Ashburn 2.224
Woodbridge 2.089
Singapore 1.868
Hong Kong 1.573
Ann Arbor 1.419
Fairfield 1.362
Chandler 1.349
Houston 1.246
Serra 1.211
San Jose 1.154
Dallas 948
Milan 909
Santa Clara 897
Sofia 726
Shanghai 634
Beijing 610
Seattle 554
Wilmington 505
New York 483
Cambridge 482
Ottawa 457
Jacksonville 400
Izmir 391
Boardman 349
Princeton 322
Los Angeles 285
Lawrence 275
Nanjing 261
Lauterbourg 257
Medford 256
Hefei 246
Tokyo 216
Ho Chi Minh City 192
Rome 182
Pisa 177
Seoul 167
Council Bluffs 156
Des Moines 148
Helsinki 147
Dearborn 146
Istanbul 141
Florence 139
Dong Ket 136
Hanoi 127
Bern 122
Redondo Beach 121
Redwood City 119
London 118
Marseille 111
Nanchang 111
Boulder 110
Munich 105
Buffalo 99
Vienna 87
São Paulo 86
San Diego 80
Abidjan 69
Frankfurt am Main 69
Lagos 69
Columbus 68
Orem 67
The Dalles 67
Jüchen 60
Livorno 57
Ogden 56
Lucca 49
Shenyang 49
Brussels 48
Hyderabad 48
San Francisco 48
Hebei 46
Pune 46
Chicago 45
Kunming 45
Mumbai 44
Washington 44
Guangzhou 41
Chennai 40
Turku 40
Tianjin 39
Belo Horizonte 38
Nürnberg 37
Warsaw 36
Norwalk 35
Phoenix 35
Rio de Janeiro 35
Jiaxing 33
Hangzhou 32
Dakar 31
Nuremberg 30
Toronto 29
Turin 29
Amsterdam 28
Auburn Hills 28
Changsha 28
Bologna 27
Da Nang 27
Denver 27
Jinan 26
Manchester 25
Totale 30.955
Nome #
COMPOSTO INIBITORE DELL’ENZIMA LATTATO DEIDROGENASI (LDH) E COMPOSIZIONE FARMACEUTICA CHE COMPRENDE TALE COMPOSTO 360
4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors 329
Glycoconjugated metal complexes as cancer diagnostic and therapeutic agents 315
GLUT1 and LOX inhibitors as perspective anticancer agents tackling glucose avidity and ECM remodeling in tumors 270
Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase. 265
Receptor-based virtual screening evaluation for the identification of estrogen receptor β ligands 260
New activators of SIRT1 enzyme for the treatment of cardiovascular and cardiometabolic pathologies 249
Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents 238
Identification of Lactate Dehydrogenase 5 Inhibitors using Pharmacophore- Driven Consensus Docking 234
Sonde diagnostiche per evidenziare all’infrarosso cellule e tessuti affetti da condizioni patologiche o metaboliche 232
Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents 230
Nuovi attivatori dell’enzima SIRT1 per il trattamento delle patologie cardiovascolari e cardiometaboliche 224
First examples of H2S-releasing glycoconjugates: stereoselective synthesis and anticancer activities 222
New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design,Synthesis, and Biopharmacological Properties 220
Structural optimization of 4-chlorobenzoylpiperidine derivatives for the development of potent, reversible and selective monoacylglycerol lipase (MAGL) inhibitors 220
Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors 220
A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by using a Pharmacophore-Based Approach 219
Glucose transporters: production, crystallization and inhibition 217
Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor 217
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors 216
Diagnostic probes to detect cells and tissues afflicted with a pathological or metabolic condition by means of infrared spectroscopy 211
Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors 210
Rational Development of MAGL Inhibitors 210
Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes 209
Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death 207
A Convenient Three-Component Synthesis of Substituted Cyclopentadienyl Tricarbonyl Rhenium Complexes 205
Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors 203
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 203
Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition 203
A role for lactate dehydrogenase in the c-Met/HGF signaling axis 203
Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials 203
Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands 201
Historical perspective of tumor glycolysis: a century with Otto Warburg 200
Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor 200
COMPOUNDS INHIBITING THE ENZYME LACTATE DEHYDROGENASE (LDH), PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 200
Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform a (LDH-A) as Starvation Agents against Cancer Cells 199
Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors 198
Reactive Oxygen Species Synergize to Potently and Selectively Induce Cancer Cell Death 198
Tackling tumors by exploiting their glucose avidity and high rate of glycolysis 197
Identification of new FYN kinase inhibitors using a FLAP-based approach 196
Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand 195
Antiproliferative oxime derivatives that inhibit glucose transporter 1 (GLUT1) in cancer cells 195
Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer 195
METAL SALT-PROMOTED ALDOL REACTION OF SILYL ENOL ETHERS WITH ALDEHYDES 194
Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors 194
Anticancer agents interacting with membrane glucose transporters 194
Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies 193
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 193
An Update on Patents Covering Agents That Interfere with the Cancer Glycolytic Cascade 193
Risks and Benefits Related to Alimentary Exposure to Xenoestrogens 193
Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors 193
A Polymer-Supported Phosphazine as a Stable and Practical Reagent in the Three-Component Synthesis of Substituted (Cyclopentadienyl)tricarbonylrhenium Complexes 192
4-[6-(dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor 192
Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer 191
Functionalized aliphatic polyketones with germicide activity 191
Hypoxia-activated lysyl oxidase (LOX) inhibitors in the treatment of highly invasive and metastatic cancer 190
CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides 190
Estrogen receptor ligands: a patent review update 188
Nuovi agenti antivirali a struttura N-idrossiindrol-carbossamidica 186
Pharmacological study on the cardiovascular activity of no-sartans, pharmacodynamic hybridsexhibiting at1-antagonist and no-donor properties 186
Highly Selective Salicylketoxime-Based Estrogen Receptor β Agonists Display Antiproliferative Activities in a Glioma Model 186
Spirocyclic Benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel 186
Cyclic Ketoximes as Estrogen Receptorβ Selective Agonists 184
Anticancer Agents That Counteract Tumor Glycolysis 183
QSAR models for predicting enzymatic hydrolysis of new chemical entities in 'soft-drug' design 183
Design, Synthesis, and Evaluation of GLUT Inhibitors 183
Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer 183
Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes 182
An update on therapeutic opportunities offered by cancer glycolytic metabolism 182
Boronic Acids in the Three-Component Synthesis of Carbon-Substituted Cyclopentadienyl Tricarbonyl Rhenium Complexes 181
Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds 181
Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways 181
7-Nitrobenzofurazan (NBD)-Derivatives Of 5'-N-Ethylcarboxamidoadenosine (NECA) As New Fluorescent Probes For Human A3 Adenosine Receptors 180
New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties 179
N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation 179
Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia 179
Selective activators of estrogen receptor beta based on the aldoxime and ketoxime scaffolds 178
Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands 178
Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents 177
Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives 175
New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) 175
Curaxins: A New Family of Non-genotoxic Multitargeted Anticancer Agents 175
Radiosensitizing potentialof small organic molecules toward hypoxic tumor cells in the radiotherapy 174
Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells 174
NO-Sartans: A New Class of Pharmacodynamic Hybrids as Cardiovascular Drugs 173
Natural compounds as inhibitors of lactate dehydrogenase 173
Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity 173
Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5 172
Salicylketoximes that target glucose transporter 1 restrict energy supply to lung cancer cells 172
Salicylketoximes as inhibitors of Glucose Transporters 171
a) Analgesici "pesanti": i Dramadoli; b) Ombrelli molecolari 170
Drug-likeness of multiple-binding drugs 170
Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors 170
Preclinical emergence of novel lactate dehydrogenase inhibitors as potent antitumor agents in hypoxic models of pancreatic cancer: molecular mechanisms underlying their synergistic interaction with gemcitabine 168
Synthesis of a Resveratrol Analogue with High Ceramide-Mediated Proapoptotic Activity on Human Breast Cancer Cells 168
Biphenyl-Derivatives Possessing Tertiary Amino Groups as ß-Secretase (BACE1) Inhibitors 168
New N-n-propyl-substituted 3-Aryl and 3-Cyclohexyl piperidines as partial agonists at the D4 dopamine receptor 167
The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies 166
BACE1 inhibitory activities of enantiomerically pure, variously substituted N-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropyl) arylsulfonamides 164
Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5) 164
Totale 19.878
Categoria #
all - tutte 120.055
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 120.055


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021366 0 0 0 0 0 0 0 0 0 0 0 366
2021/20223.401 116 293 80 199 521 490 129 194 84 120 180 995
2022/20233.837 489 497 260 395 467 506 41 296 606 29 205 46
2023/20243.378 446 423 353 261 486 585 126 102 57 74 121 344
2024/20258.764 84 391 254 525 671 784 644 498 927 1.167 932 1.887
2025/20269.578 527 1.164 1.130 741 846 926 1.585 482 701 862 447 167
Totale 44.637