MANERA, CLEMENTINA
 Distribuzione geografica
Continente #
NA - Nord America 16.053
AS - Asia 7.034
EU - Europa 6.931
SA - Sud America 1.019
AF - Africa 246
OC - Oceania 17
Continente sconosciuto - Info sul continente non disponibili 6
Totale 31.306
Nazione #
US - Stati Uniti d'America 13.372
IT - Italia 2.677
CA - Canada 2.610
CN - Cina 2.123
SG - Singapore 2.067
HK - Hong Kong 1.182
SE - Svezia 1.079
BR - Brasile 860
DE - Germania 673
BG - Bulgaria 481
VN - Vietnam 466
TR - Turchia 385
PL - Polonia 366
GB - Regno Unito 276
KR - Corea 256
FI - Finlandia 248
RU - Federazione Russa 233
UA - Ucraina 214
FR - Francia 208
AT - Austria 180
IN - India 170
CH - Svizzera 87
JP - Giappone 83
CI - Costa d'Avorio 60
AR - Argentina 49
BD - Bangladesh 49
MX - Messico 41
NG - Nigeria 41
IQ - Iraq 37
NL - Olanda 37
MA - Marocco 36
GR - Grecia 35
PK - Pakistan 32
ES - Italia 31
SA - Arabia Saudita 31
BE - Belgio 30
IL - Israele 26
EC - Ecuador 24
ID - Indonesia 24
SN - Senegal 22
CZ - Repubblica Ceca 19
VE - Venezuela 19
ZA - Sudafrica 17
AU - Australia 16
PE - Perù 16
EG - Egitto 15
CO - Colombia 14
PY - Paraguay 13
TN - Tunisia 13
UZ - Uzbekistan 13
IR - Iran 11
KE - Kenya 11
UY - Uruguay 11
IE - Irlanda 10
PH - Filippine 10
NP - Nepal 9
AE - Emirati Arabi Uniti 8
AZ - Azerbaigian 8
JM - Giamaica 8
RS - Serbia 7
AL - Albania 6
DZ - Algeria 6
ET - Etiopia 6
EU - Europa 6
KZ - Kazakistan 6
RO - Romania 6
BJ - Benin 5
CL - Cile 5
GE - Georgia 5
JO - Giordania 5
BO - Bolivia 4
CR - Costa Rica 4
HU - Ungheria 4
LT - Lituania 4
PS - Palestinian Territory 4
PT - Portogallo 4
TT - Trinidad e Tobago 4
BA - Bosnia-Erzegovina 3
BY - Bielorussia 3
DM - Dominica 3
GA - Gabon 3
GY - Guiana 3
LB - Libano 3
MY - Malesia 3
PA - Panama 3
ZM - Zambia 3
AM - Armenia 2
AO - Angola 2
BB - Barbados 2
BH - Bahrain 2
BW - Botswana 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
LI - Liechtenstein 2
MK - Macedonia 2
MN - Mongolia 2
SK - Slovacchia (Repubblica Slovacca) 2
SY - Repubblica araba siriana 2
TG - Togo 2
BN - Brunei Darussalam 1
Totale 31.287
Città #
Montreal 2.316
Woodbridge 1.518
Ann Arbor 1.287
Ashburn 1.284
Hong Kong 1.175
Singapore 1.142
Houston 994
Fairfield 950
Chandler 912
Santa Clara 802
Dallas 654
Milan 537
Serra 533
Sofia 481
Shanghai 430
Beijing 406
Wilmington 364
Seattle 342
Hefei 337
Cambridge 307
New York 276
Jacksonville 268
Ottawa 245
Dong Ket 243
Seoul 240
Boardman 237
Izmir 234
Princeton 226
Lawrence 184
Pisa 183
Los Angeles 182
Medford 163
Vienna 153
Nanjing 148
Munich 115
Des Moines 109
Marseille 99
Istanbul 98
Dearborn 86
Florence 83
Bern 82
Rome 78
Buffalo 77
Redondo Beach 77
São Paulo 73
Tokyo 64
Lucca 60
Abidjan 59
San Diego 59
London 56
Boulder 54
Council Bluffs 54
Frankfurt am Main 53
Jüchen 53
The Dalles 53
Columbus 52
Ho Chi Minh City 51
Redwood City 49
Nanchang 45
Turku 42
Lagos 41
Fuzhou 39
Shenyang 39
Warsaw 39
Livorno 37
Ogden 35
Pune 35
Helsinki 34
Kunming 33
San Jose 33
Pistoia 30
Brussels 29
Jiaxing 28
Hanoi 27
Pescara 27
San Francisco 27
Chicago 26
Falls Church 26
Hangzhou 25
Nuremberg 25
Rio de Janeiro 25
Bremen 24
Casablanca 24
Düsseldorf 23
Grafing 23
Guangzhou 23
Norwalk 23
Belo Horizonte 22
Dakar 22
Hyderabad 22
Brooklyn 21
Genoa 21
Brasília 20
Pessac 20
Phoenix 20
Atlanta 19
Auburn Hills 19
Changsha 19
Denver 19
Hebei 19
Totale 22.597
Nome #
Synthesis and a- and ß-adrenergic activity of spiromorpholines structurally related to sympathomimetic catecholamines 2.775
Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells 339
4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors 315
1,2,3-triazolo [4,5-d] pyridazines-V. Preparation and adenosine receptor binding of new 4-amino derivatives. 294
1,2,3-Triazolo[1,5-a][1,4]- and 1,2,3-Triazolo[1,5-a][1,5]benzodiazepine derivatives: synthesis and benzodiazepine receptor binding. 289
1,2,3-TRIAZOLO[4,5-e]-1,2,4-TRIAZOLO[3,4-c]PYRIMIDINES 266
1,2,3-Triazolo[4,5-d]-1,2,4-triazolo[4,3-b]pyridazines 251
1,2,3-Triazolo[1,5-a]quinoxalines: synthesis and binding to benzodiazepine and adenosine receptors 247
Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts 232
1,2,3-TRIAZOLO[4,5-D]PYRIDAZINES. PART VI. NEW 1-SUBSTITUTED-4-AMINO DERIVATIVES AND THEIR AFFINITY TOWARDS A1 AND A2 ADENOSINE RECEPTORS 230
Application of An Improved HPLC-FL Method to Screen Serine Palmitoyl Transferase Inhibitors 230
Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer 227
1,2,3-triazolo[4,5-d]pyridazines - Part VI. New 1-substituted-4-amino derivatives and their affinity towards A(1) and A(2A) adenosine receptors 226
X-ray analisis, theoretical studies and a-adrenergic biopharmacological properties of 1-(2,5-dimethoxyphenyl)-2-aminoethanol and its morpholine analogue 224
1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors. 223
Diversity of yeast community composition in olive oil from two different areas in Tuscany 222
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity 217
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system 214
A NEW HPLC METHOD FOR THALIDOMIDE DETECTION IN HUMAN PLASMA 211
Synthesis and antitumor evaluation of 1,8-naphthyridine-2-(1H)-on-3carboxamide derivatives as CB2 selective agonists 210
X-Ray analysis, theoretical studies and alfa-adrenergic biopharmacological properties of 1-(2,5-dimethoxyphenyl)-2-aminoethanol and its morpholine analogue. 208
Beyond the Direct Activation of Cannabinoid Receptors: New Strategies to Modulate the Endocannabinoid System in CNS-Related Diseases 208
Anti-proliferative activity of oleocanthal in human malignant cutaneous melanoma cells 203
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor 200
1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor 198
Identification of the first synthetic allosteric modulator of the CB2receptors and evidence of its efficacy for neuropathic pain relief 196
CONFORMATIONALLY RESTRAINED ANALOGS OF SYMPATHOMIMETIC CATECHOLAMINES - SYNTHESIS AND ADRENERGIC ACTIVITY OF TETRAHYDROBENZOCYCLOHEPTENE DERIVATIVES 192
Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase 192
Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma 191
Tyrosol-enriched tomatoes by diffusion across the fruit peel from a chitosan coating: a proposal of functional food 191
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands 190
Rational design, synthesis, biological evaluation and labelling of selective cannabinoid CB2 receptor agonists as anticancer agents 187
Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists 186
Design, synthesis and preliminary evaluation of (18)F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor 186
CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides 184
Structural optimization of 4-chlorobenzoylpiperidine derivatives for the development of potent, reversible and selective monoacylglycerol lipase (MAGL) inhibitors 184
The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation 184
Composition of health-promoting phenolic compounds in two extra-virgin olive oils and diversity of associated yeasts 182
4-[6-(dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor 182
Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: Implications for drug discovery 181
Conformationally Restrained Analogs of Sympathomimetic Catecholamines. Synthesis, Conformational Analysis, and Adrenergic Activity of Isochroman Derivatives 181
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 178
Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system 178
Design, Synthesis and biological evaluation of new 1,8-naphthyridin-4(1h)-on-3-carboxamide and quinolin-4(1h)-on-3-carboxamide derivatives as CB2 selective agonists 177
Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands 174
Conformationally restrained β -blocking oxime ethers: synthesis and β -adrenergic properties of diastereoisomeric anti and syn 2-(5-isoxazolidinyl)ethanolamines 173
Cannabinoid ReceptorActivation Induces Apoptosis through Tumor Necrosis Factor A Mediated Ceramide De novo Synthesis in Colon Cancer Cells, 172
SYNTHESIS AND BETA-BLOCKING ACTIVITY OF (R,S)-(E)-OXIMEETHERS OF 2,3-DIHYDRO-1,8-NAPHTHYRIDINE AND 2,3-DIHYDROTHIOPYRANO[2,3-B]PYRIDINE: IDENTIFICATION OF BETA 3-ANTAGONISTS 170
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors 170
Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alfa- and beta-adrenergic receptors 169
Stereochemistry and dynamics of the hydrobromide of 1-(aminomethyl)-5,6-dihydroxyisochroman, semirigid analogue of catecholamines 169
Conformationally restrained beta-blocking oxime ethers: synthesis and beta-adrenergic properties of diastereoisomeric anti and syn 2-(5-isoxazolidinyl)ethanolamines 168
Immunomodulatory properties of 1,2-dihydro-4-hydroxy-2-oxo-1,8-naphthyridine-3-carboxamide derivative VL15 168
A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress 168
Cannabinoid CB2/CB1 Selectivity. Receptor Modeling and Automated Docking Analysis 167
Conformationally restrained analogues of sympathomimetic catecholamines: Synthesis and adrenergic activity of 5,6- and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1(2H)-2′,5′- morpholines] 164
Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids 164
Modified RP-LC of Phenylthiocarbamyl Amino Acid Adducts in Plasma Acetonitrile Extracts using Multiple Internal Standards and Photo-Diode UV Detection. 163
Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands 163
Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology. 162
A2A receptor ligands: Past, present and future trends 161
Immuno-Modulatory Properties of a Quinolin-2-(1H)-on-3-Carboxamide Derivative: Relevance in Multiple Sclerosis 160
New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2 159
Synthetic cannabinoid receptor agonists and antagonists: implication in CNS disorders 159
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold 158
Synthesis and evaluation of antihypertensive activity of 1,8-naphthyridine derivatives. Part X 158
Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol 158
Analgesici oppiodi: HPLC-FL e LC-UV-ESI-MS/MS per la determinazione simultanea del tramadolo e dei suoi metaboliti nel plasma di cavallo 157
Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis 157
PHARMACOKINETICS OF INTRAVENOUS AND INTRAMUSCULAR PARECOXIB IN HEALTHY BEAGLES 156
Immune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives. 155
A New 4-phenyl-1,8-naphthyridine Derivative Affects Carcinoma Cell Proliferation by Impairing Cell Cycle Progression and Inducing Apoptosis 154
Role of the benzylic hydroxyl group of adrenergic catecholamines in eliciting a-adrenergic activity. Synthesis and a1- and a2-adrenergic activity of 3-phenyl-3-piperidinols and of their desoxy analogs 154
Determination of water-soluble vitamins in multivitamin dietary supplements and in artichokes by micellar electrokinetic chromatography. 154
HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF THALIDOMIDE IN PATIENTS AFFECTED BY HEPATOCELLULAR CARCINOMA 153
Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice 153
Role of the benzylic hydroxyl group of adrenergic cattecholamines in eliciting alpha-adrenergic activity. Synthesis and alpha1- and alpha2-adrenergic activity of 3-phenyl-3-piperidinols and of their desoxy analogs 152
Spiropiperidine strutturalmente correlate alle catecolamine. Sintesi ed attività recettoriale a- e ß-adrenergica 151
The cannabinoid CB2/CB1 selectivity. Homology modelling and automated docking analysis 151
Determination of tramadol and metabolites by HPLC-FL and HPLC-MS/MS in urine of dogs 151
Structure-based virtual screening: Identification of novel CB2 receptor ligands 150
Design, synthesis, and biological evaluation of 1,8-naphthyridin-2(1H)-on-3-carboxamide, quinolin-2(1H)-on-3-carboxamide and 2-oxo-1,2-dihydropyridine-3-carboxamide derivatives as CB2 selective ligands 149
1,8-naphthyridine derivatives potent and selective A1 adenosine antagonists 149
Synthesis and antiplatelet activity of some 3-phenyl-1,8-naphthyridine derivatives 149
Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells 146
Synthesis and b-blocking activity of (R,S)-(E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3-b]-pyridine: potential antihypertensive agents. Part IX 146
ASSESSMENT OF THE PHARMACOKINETIC PROFILE OF TRAMADOL AND ITS MAIN METABOLITES IN PLASMA AND URINE FORM DOGS ORALLY ADMINISTERED WITH CONTRAMAL®, WITH OR WITHOUT FREEZE-DRIED GRAPE-FRUIT JUICE 145
Synthesis of New 1,2,3-triazolo[1,2-a]benzotriazole derivatives or substituted 2,3-benzo-1,3a,6,6a-tetraazapentalenes. II” 144
Synthesis and biological evaluation of 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists 144
Study on Affinity Profile toward Native and Bovine Adenosine Receptors of a Series of 1,8-Naphthyridine Derivatives 143
Carbazole-containing arylcarboxamides as BACE1 inhibitors 143
IN VITRO METABOLISM OF TRAMADOL IN HORSES: PRELIMINARY DATA 142
Sintesi e attività recettoriale adrenergica di analoghi tetraidronaftalenici di catecolamine simpatomimetiche 141
PHARMACOKINETICS OF DIFFERENT FORMULATIONS OF TRAMADOL IN THE HORSE 141
Conformationally restrained β -blocking oxime ethers. 4. Chiral 2-(3'-(5'-p-chlorophenyl)isoxazolidinyl)ethanolamines as conformationally restrained analogs of methyloxyiminomethyl (MOIM) β -adrenergic antagonists: synthesis, configuration and β -adrenergic properties 140
Stereoselective synthesis and beta-blocking activity of substituted (E)- and (Z)- 4(1H) - [1- (3 - alkylamino - 2 - hydroxypropyl) oximino - 2,3 - dihydro - 1,8 - naphthyridine. Potential antihypertensive agents. Part VI 140
(E)-(ARYLMETHYLENEAMINOXY)ACETAMIDES AS ANALOGS OF NEUROLEPTIC BENZAMIDES - SYNTHESIS AND D-2-DOPAMINERGIC BINDING-AFFINITY 140
Indoles and Related Compounds as Cannabinoid Ligands, 140
Unusual nitration of substituted 7-amino-1,8-naphthyridine in the synthesis of compounds with antiplatelet activity 139
CONFORMATIONAL EFFECTS ON THE ACTIVITY OF DRUGS .13. A REVISION OF PREVIOUSLY PROPOSED MODELS FOR THE ACTIVATION OF ALPHA-ADRENERGIC AND BETA-ADRENERGIC RECEPTORS 139
Totale 20.646
Categoria #
all - tutte 81.973
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 81.973


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.068 0 0 0 0 0 0 127 155 175 158 85 368
2021/20222.425 80 255 52 123 385 300 114 131 96 66 161 662
2022/20233.043 397 418 246 250 348 382 33 216 459 29 142 123
2023/20244.780 305 245 280 165 339 258 152 35 31 2.650 88 232
2024/20256.503 28 235 125 385 605 697 526 391 602 793 785 1.331
2025/20264.596 562 1.008 889 768 656 694 19 0 0 0 0 0
Totale 31.828