MANERA, CLEMENTINA
 Distribuzione geografica
Continente #
NA - Nord America 18.533
EU - Europa 9.348
AS - Asia 8.022
SA - Sud America 1.110
Continente sconosciuto - Info sul continente non disponibili 537
AF - Africa 283
OC - Oceania 18
Totale 37.851
Nazione #
US - Stati Uniti d'America 15.779
IT - Italia 2.835
CA - Canada 2.645
SG - Singapore 2.394
CN - Cina 2.215
FI - Finlandia 2.179
HK - Hong Kong 1.248
SE - Svezia 1.100
BR - Brasile 907
VN - Vietnam 727
DE - Germania 697
BG - Bulgaria 481
FR - Francia 403
TR - Turchia 390
PL - Polonia 370
GB - Regno Unito 306
KR - Corea 257
RU - Federazione Russa 236
IN - India 222
UA - Ucraina 217
AT - Austria 182
JP - Giappone 165
CH - Svizzera 94
BD - Bangladesh 64
CI - Costa d'Avorio 62
AR - Argentina 56
MX - Messico 51
IQ - Iraq 49
NL - Olanda 48
PK - Pakistan 47
NG - Nigeria 44
ES - Italia 38
SA - Arabia Saudita 38
MA - Marocco 37
GR - Grecia 36
ID - Indonesia 33
BE - Belgio 32
IL - Israele 28
EC - Ecuador 27
VE - Venezuela 26
CO - Colombia 24
ZA - Sudafrica 24
SN - Senegal 23
PH - Filippine 21
CZ - Repubblica Ceca 20
PE - Perù 19
EG - Egitto 18
TN - Tunisia 18
AU - Australia 17
IE - Irlanda 16
KE - Kenya 16
PY - Paraguay 16
UZ - Uzbekistan 16
UY - Uruguay 14
JM - Giamaica 13
IR - Iran 11
NP - Nepal 11
CL - Cile 10
CR - Costa Rica 10
RO - Romania 10
AE - Emirati Arabi Uniti 9
AZ - Azerbaigian 9
DZ - Algeria 9
ET - Etiopia 9
JO - Giordania 8
AL - Albania 7
BO - Bolivia 7
KZ - Kazakistan 7
MY - Malesia 7
RS - Serbia 7
EU - Europa 6
GE - Georgia 6
PS - Palestinian Territory 6
TT - Trinidad e Tobago 6
BJ - Benin 5
HN - Honduras 5
LT - Lituania 5
NI - Nicaragua 5
TH - Thailandia 5
BY - Bielorussia 4
HU - Ungheria 4
LB - Libano 4
PA - Panama 4
PT - Portogallo 4
BA - Bosnia-Erzegovina 3
DM - Dominica 3
GA - Gabon 3
GY - Guiana 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
ZM - Zambia 3
AM - Armenia 2
AO - Angola 2
BB - Barbados 2
BH - Bahrain 2
BW - Botswana 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
GT - Guatemala 2
KG - Kirghizistan 2
Totale 37.279
Città #
Montreal 2.325
Helsinki 1.964
Woodbridge 1.518
Ashburn 1.476
Singapore 1.383
Ann Arbor 1.287
Hong Kong 1.223
Houston 1.002
Fairfield 950
Chandler 912
San Jose 890
Santa Clara 824
Dallas 669
Milan 557
Serra 533
Sofia 481
Shanghai 436
Beijing 418
Wilmington 364
Council Bluffs 347
Seattle 345
Hefei 337
Cambridge 309
New York 296
Jacksonville 272
Ottawa 246
Dong Ket 243
Seoul 241
Boardman 240
Izmir 235
Los Angeles 235
Princeton 226
Pisa 187
Lawrence 184
Lauterbourg 164
Medford 163
Vienna 154
Nanjing 148
Tokyo 144
Ho Chi Minh City 135
Munich 117
Des Moines 111
Istanbul 99
Marseille 99
Florence 96
Hanoi 95
Buffalo 86
Dearborn 86
Rome 84
Bern 82
Redondo Beach 77
São Paulo 77
Frankfurt am Main 65
Columbus 62
Lucca 62
Abidjan 61
London 61
San Diego 61
Boulder 54
The Dalles 54
Jüchen 53
Redwood City 49
Nanchang 45
Atlanta 44
Lagos 44
Orem 44
Turku 42
Warsaw 41
Fuzhou 39
Shenyang 39
Livorno 38
Pune 36
Ogden 35
Kunming 33
Brussels 31
Pistoia 30
Chicago 29
San Francisco 29
Jiaxing 28
Brooklyn 27
Da Nang 27
Nuremberg 27
Pescara 27
Falls Church 26
Rio de Janeiro 26
Genoa 25
Hangzhou 25
Bremen 24
Casablanca 24
Düsseldorf 24
Guangzhou 24
Phoenix 24
Dakar 23
Grafing 23
Hyderabad 23
Norwalk 23
Belo Horizonte 22
Denver 22
Baghdad 21
Brasília 20
Totale 26.888
Nome #
Synthesis and a- and ß-adrenergic activity of spiromorpholines structurally related to sympathomimetic catecholamines 4.648
Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells 374
4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors 332
1,2,3-Triazolo[1,5-a][1,4]- and 1,2,3-Triazolo[1,5-a][1,5]benzodiazepine derivatives: synthesis and benzodiazepine receptor binding. 332
1,2,3-triazolo [4,5-d] pyridazines-V. Preparation and adenosine receptor binding of new 4-amino derivatives. 319
1,2,3-TRIAZOLO[4,5-e]-1,2,4-TRIAZOLO[3,4-c]PYRIMIDINES 291
1,2,3-Triazolo[4,5-d]-1,2,4-triazolo[4,3-b]pyridazines 273
1,2,3-Triazolo[1,5-a]quinoxalines: synthesis and binding to benzodiazepine and adenosine receptors 270
1,2,3-TRIAZOLO[4,5-D]PYRIDAZINES. PART VI. NEW 1-SUBSTITUTED-4-AMINO DERIVATIVES AND THEIR AFFINITY TOWARDS A1 AND A2 ADENOSINE RECEPTORS 261
Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer 260
1,2,3-triazolo[4,5-d]pyridazines - Part VI. New 1-substituted-4-amino derivatives and their affinity towards A(1) and A(2A) adenosine receptors 256
Application of An Improved HPLC-FL Method to Screen Serine Palmitoyl Transferase Inhibitors 249
Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts 248
Diversity of yeast community composition in olive oil from two different areas in Tuscany 248
X-ray analisis, theoretical studies and a-adrenergic biopharmacological properties of 1-(2,5-dimethoxyphenyl)-2-aminoethanol and its morpholine analogue 243
Design, synthesis and biological evaluation of new H2S-releasing rivastigmine derivatives as neuroprotective molecules 236
Beyond the Direct Activation of Cannabinoid Receptors: New Strategies to Modulate the Endocannabinoid System in CNS-Related Diseases 234
1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors. 233
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity 232
Identification of the first synthetic allosteric modulator of the CB2receptors and evidence of its efficacy for neuropathic pain relief 230
A NEW HPLC METHOD FOR THALIDOMIDE DETECTION IN HUMAN PLASMA 227
X-Ray analysis, theoretical studies and alfa-adrenergic biopharmacological properties of 1-(2,5-dimethoxyphenyl)-2-aminoethanol and its morpholine analogue. 227
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system 227
Synthesis and antitumor evaluation of 1,8-naphthyridine-2-(1H)-on-3carboxamide derivatives as CB2 selective agonists 226
Anti-proliferative activity of oleocanthal in human malignant cutaneous melanoma cells 223
Structural optimization of 4-chlorobenzoylpiperidine derivatives for the development of potent, reversible and selective monoacylglycerol lipase (MAGL) inhibitors 222
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor 222
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors 220
Tyrosol-enriched tomatoes by diffusion across the fruit peel from a chitosan coating: a proposal of functional food 218
1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor 217
Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma 211
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands 210
Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands 205
Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: Implications for drug discovery 204
The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation 204
Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands 204
New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2 203
Rational design, synthesis, biological evaluation and labelling of selective cannabinoid CB2 receptor agonists as anticancer agents 203
Composition of health-promoting phenolic compounds in two extra-virgin olive oils and diversity of associated yeasts 203
CONFORMATIONALLY RESTRAINED ANALOGS OF SYMPATHOMIMETIC CATECHOLAMINES - SYNTHESIS AND ADRENERGIC ACTIVITY OF TETRAHYDROBENZOCYCLOHEPTENE DERIVATIVES 202
Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase 202
Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists 201
Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids 201
SYNTHESIS AND BETA-BLOCKING ACTIVITY OF (R,S)-(E)-OXIMEETHERS OF 2,3-DIHYDRO-1,8-NAPHTHYRIDINE AND 2,3-DIHYDROTHIOPYRANO[2,3-B]PYRIDINE: IDENTIFICATION OF BETA 3-ANTAGONISTS 199
Design, synthesis and preliminary evaluation of (18)F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor 198
Efficacy of memantine prodrug microemulsion in a Preclinical model of tendinopathy 197
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 196
4-[6-(dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor 195
Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells 194
CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides 193
Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system 193
A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress 190
Conformationally Restrained Analogs of Sympathomimetic Catecholamines. Synthesis, Conformational Analysis, and Adrenergic Activity of Isochroman Derivatives 190
Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alfa- and beta-adrenergic receptors 189
Synthetic cannabinoid receptor agonists and antagonists: implication in CNS disorders 187
Role of the benzylic hydroxyl group of adrenergic cattecholamines in eliciting alpha-adrenergic activity. Synthesis and alpha1- and alpha2-adrenergic activity of 3-phenyl-3-piperidinols and of their desoxy analogs 186
Cannabinoid ReceptorActivation Induces Apoptosis through Tumor Necrosis Factor A Mediated Ceramide De novo Synthesis in Colon Cancer Cells, 184
Conformationally restrained beta-blocking oxime ethers: synthesis and beta-adrenergic properties of diastereoisomeric anti and syn 2-(5-isoxazolidinyl)ethanolamines 183
Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology. 183
Design, Synthesis and biological evaluation of new 1,8-naphthyridin-4(1h)-on-3-carboxamide and quinolin-4(1h)-on-3-carboxamide derivatives as CB2 selective agonists 182
Cannabinoid CB2/CB1 Selectivity. Receptor Modeling and Automated Docking Analysis 182
Immuno-Modulatory Properties of a Quinolin-2-(1H)-on-3-Carboxamide Derivative: Relevance in Multiple Sclerosis 181
Conformationally restrained β -blocking oxime ethers: synthesis and β -adrenergic properties of diastereoisomeric anti and syn 2-(5-isoxazolidinyl)ethanolamines 181
Analgesici oppiodi: HPLC-FL e LC-UV-ESI-MS/MS per la determinazione simultanea del tramadolo e dei suoi metaboliti nel plasma di cavallo 180
Immunomodulatory properties of 1,2-dihydro-4-hydroxy-2-oxo-1,8-naphthyridine-3-carboxamide derivative VL15 180
Modified RP-LC of Phenylthiocarbamyl Amino Acid Adducts in Plasma Acetonitrile Extracts using Multiple Internal Standards and Photo-Diode UV Detection. 180
Stereochemistry and dynamics of the hydrobromide of 1-(aminomethyl)-5,6-dihydroxyisochroman, semirigid analogue of catecholamines 179
Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice 177
Conformationally restrained analogues of sympathomimetic catecholamines: Synthesis and adrenergic activity of 5,6- and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1(2H)-2′,5′- morpholines] 175
A2A receptor ligands: Past, present and future trends 174
Spiropiperidine strutturalmente correlate alle catecolamine. Sintesi ed attività recettoriale a- e ß-adrenergica 173
Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol 173
Determination of water-soluble vitamins in multivitamin dietary supplements and in artichokes by micellar electrokinetic chromatography. 172
Synthesis and evaluation of antihypertensive activity of 1,8-naphthyridine derivatives. Part X 170
Synthesis and antiplatelet activity of some 3-phenyl-1,8-naphthyridine derivatives 169
1,8-naphthyridine derivatives potent and selective A1 adenosine antagonists 168
PHARMACOKINETICS OF INTRAVENOUS AND INTRAMUSCULAR PARECOXIB IN HEALTHY BEAGLES 168
Role of the benzylic hydroxyl group of adrenergic catecholamines in eliciting a-adrenergic activity. Synthesis and a1- and a2-adrenergic activity of 3-phenyl-3-piperidinols and of their desoxy analogs 168
Study of the virucidal effect on Human Adenovirus type 5 of polysaccharides extracted from Arthrospira platensis and Dunaliella salina 166
Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis 166
The cannabinoid CB2/CB1 selectivity. Homology modelling and automated docking analysis 165
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold 165
Immune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives. 164
Determination of tramadol and metabolites by HPLC-FL and HPLC-MS/MS in urine of dogs 164
Structure-based virtual screening: Identification of novel CB2 receptor ligands 163
Synthesis and b-blocking activity of (R,S)-(E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3-b]-pyridine: potential antihypertensive agents. Part IX 163
A New 4-phenyl-1,8-naphthyridine Derivative Affects Carcinoma Cell Proliferation by Impairing Cell Cycle Progression and Inducing Apoptosis 163
ASSESSMENT OF THE PHARMACOKINETIC PROFILE OF TRAMADOL AND ITS MAIN METABOLITES IN PLASMA AND URINE FORM DOGS ORALLY ADMINISTERED WITH CONTRAMAL®, WITH OR WITHOUT FREEZE-DRIED GRAPE-FRUIT JUICE 162
HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF THALIDOMIDE IN PATIENTS AFFECTED BY HEPATOCELLULAR CARCINOMA 162
The Interplay between Cannabinoid Receptors and Microglia in the Pathophysiology of Alzheimer's Disease 159
Design, synthesis, and biological evaluation of 1,8-naphthyridin-2(1H)-on-3-carboxamide, quinolin-2(1H)-on-3-carboxamide and 2-oxo-1,2-dihydropyridine-3-carboxamide derivatives as CB2 selective ligands 159
(E)-(ARYLMETHYLENEAMINOXY)ACETAMIDES AS ANALOGS OF NEUROLEPTIC BENZAMIDES - SYNTHESIS AND D-2-DOPAMINERGIC BINDING-AFFINITY 159
CB1 receptor binding sites for NAM and PAM: A first approach for studying, new n‑butyl‑diphenylcarboxamides as allosteric modulators 158
Unraveling the Protective Role of Oleocanthal and Its Oxidation Product, Oleocanthalic Acid, against Neuroinflammation 157
Conformationally restrained β -blocking oxime ethers. 4. Chiral 2-(3'-(5'-p-chlorophenyl)isoxazolidinyl)ethanolamines as conformationally restrained analogs of methyloxyiminomethyl (MOIM) β -adrenergic antagonists: synthesis, configuration and β -adrenergic properties 156
PHARMACOKINETICS OF DIFFERENT FORMULATIONS OF TRAMADOL IN THE HORSE 156
Synthesis and biological evaluation of 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists 155
Synthesis of New 1,2,3-triazolo[1,2-a]benzotriazole derivatives or substituted 2,3-benzo-1,3a,6,6a-tetraazapentalenes. II” 153
IN VITRO METABOLISM OF TRAMADOL IN HORSES: PRELIMINARY DATA 152
Adenosine receptor modelling. A1/A2a selectivity 152
Totale 24.559
Categoria #
all - tutte 96.741
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 96.741


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.345 0 255 52 123 385 300 114 131 96 66 161 662
2022/20233.043 397 418 246 250 348 382 33 216 459 29 142 123
2023/20244.780 305 245 280 165 339 258 152 35 31 2.650 88 232
2024/20256.503 28 235 125 385 605 697 526 391 602 793 785 1.331
2025/20269.608 562 1.008 889 768 656 694 1.161 383 2.301 632 350 204
2026/20271.011 234 777 0 0 0 0 0 0 0 0 0 0
Totale 37.851