MANERA, CLEMENTINA
 Distribuzione geografica
Continente #
NA - Nord America 14.474
EU - Europa 6.685
AS - Asia 4.852
SA - Sud America 728
AF - Africa 200
OC - Oceania 17
Continente sconosciuto - Info sul continente non disponibili 6
Totale 26.962
Nazione #
US - Stati Uniti d'America 11.841
IT - Italia 2.591
CA - Canada 2.583
CN - Cina 1.530
SG - Singapore 1.171
SE - Svezia 1.067
HK - Hong Kong 912
DE - Germania 661
BR - Brasile 645
BG - Bulgaria 481
TR - Turchia 378
PL - Polonia 351
VN - Vietnam 335
GB - Regno Unito 246
RU - Federazione Russa 225
FI - Finlandia 222
UA - Ucraina 210
FR - Francia 192
AT - Austria 178
IN - India 152
CH - Svizzera 87
KR - Corea 77
CI - Costa d'Avorio 60
JP - Giappone 51
BD - Bangladesh 42
NG - Nigeria 41
GR - Grecia 33
IQ - Iraq 31
SA - Arabia Saudita 31
BE - Belgio 30
NL - Olanda 30
PK - Pakistan 27
IL - Israele 26
MX - Messico 24
AR - Argentina 20
SN - Senegal 20
CZ - Repubblica Ceca 18
AU - Australia 16
ES - Italia 16
VE - Venezuela 16
TN - Tunisia 12
UZ - Uzbekistan 12
ZA - Sudafrica 12
EC - Ecuador 10
EG - Egitto 10
KE - Kenya 10
MA - Marocco 9
NP - Nepal 9
UY - Uruguay 9
JM - Giamaica 8
PE - Perù 8
PH - Filippine 8
IE - Irlanda 7
IR - Iran 7
RS - Serbia 7
AZ - Azerbaigian 6
EU - Europa 6
ID - Indonesia 6
RO - Romania 6
AE - Emirati Arabi Uniti 5
AL - Albania 5
BJ - Benin 5
CO - Colombia 5
DZ - Algeria 5
ET - Etiopia 5
JO - Giordania 5
KZ - Kazakistan 5
PY - Paraguay 5
CL - Cile 4
HU - Ungheria 4
PT - Portogallo 4
BA - Bosnia-Erzegovina 3
BO - Bolivia 3
CR - Costa Rica 3
DM - Dominica 3
GA - Gabon 3
GE - Georgia 3
GY - Guiana 3
MY - Malesia 3
PA - Panama 3
PS - Palestinian Territory 3
TT - Trinidad e Tobago 3
ZM - Zambia 3
BB - Barbados 2
BH - Bahrain 2
BY - Bielorussia 2
DK - Danimarca 2
LB - Libano 2
LI - Liechtenstein 2
LT - Lituania 2
MN - Mongolia 2
SK - Slovacchia (Repubblica Slovacca) 2
TG - Togo 2
AM - Armenia 1
AO - Angola 1
BN - Brunei Darussalam 1
DO - Repubblica Dominicana 1
KG - Kirghizistan 1
KW - Kuwait 1
LK - Sri Lanka 1
Totale 26.949
Città #
Montreal 2.299
Woodbridge 1.518
Ann Arbor 1.287
Ashburn 1.001
Houston 982
Fairfield 950
Chandler 912
Hong Kong 905
Santa Clara 783
Singapore 604
Serra 533
Milan 530
Sofia 481
Shanghai 427
Wilmington 364
Seattle 338
Cambridge 307
Beijing 303
Jacksonville 267
Ottawa 245
Dong Ket 243
New York 243
Izmir 234
Princeton 226
Boardman 223
Lawrence 184
Pisa 181
Hefei 163
Medford 163
Vienna 151
Nanjing 147
Des Moines 109
Munich 105
Marseille 99
Istanbul 98
Los Angeles 98
Dearborn 86
Bern 82
Florence 75
Rome 75
Seoul 61
Abidjan 59
Lucca 58
San Diego 58
Boulder 54
Jüchen 53
The Dalles 53
Columbus 52
Frankfurt am Main 52
Redwood City 49
São Paulo 47
Nanchang 45
London 44
Lagos 41
Turku 40
Council Bluffs 39
Fuzhou 38
Livorno 37
Shenyang 36
Ogden 35
Pune 35
Kunming 32
Tokyo 32
Pistoia 30
Brussels 29
Jiaxing 27
Pescara 27
Falls Church 26
Dallas 25
Bremen 24
Nuremberg 24
San Francisco 24
Warsaw 24
Düsseldorf 23
Grafing 23
Norwalk 23
Hyderabad 22
Belo Horizonte 21
Dakar 20
Hangzhou 20
Pessac 20
Rio de Janeiro 20
Auburn Hills 19
Hebei 19
Helsinki 19
Quanzhou 19
Phoenix 18
Genoa 17
Guangzhou 17
Kocaeli 17
Brasília 16
Changsha 16
Orange 15
Rimini 15
Tianjin 15
Dhaka 14
Riyadh 14
Genova 12
Jeddah 12
Nürnberg 12
Totale 19.809
Nome #
Synthesis and a- and ß-adrenergic activity of spiromorpholines structurally related to sympathomimetic catecholamines 2.745
Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells 299
4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors 275
1,2,3-triazolo [4,5-d] pyridazines-V. Preparation and adenosine receptor binding of new 4-amino derivatives. 262
1,2,3-Triazolo[1,5-a][1,4]- and 1,2,3-Triazolo[1,5-a][1,5]benzodiazepine derivatives: synthesis and benzodiazepine receptor binding. 255
1,2,3-TRIAZOLO[4,5-e]-1,2,4-TRIAZOLO[3,4-c]PYRIMIDINES 238
1,2,3-Triazolo[4,5-d]-1,2,4-triazolo[4,3-b]pyridazines 228
1,2,3-Triazolo[1,5-a]quinoxalines: synthesis and binding to benzodiazepine and adenosine receptors 217
1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors. 209
Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts 208
1,2,3-TRIAZOLO[4,5-D]PYRIDAZINES. PART VI. NEW 1-SUBSTITUTED-4-AMINO DERIVATIVES AND THEIR AFFINITY TOWARDS A1 AND A2 ADENOSINE RECEPTORS 202
X-ray analisis, theoretical studies and a-adrenergic biopharmacological properties of 1-(2,5-dimethoxyphenyl)-2-aminoethanol and its morpholine analogue 195
Diversity of yeast community composition in olive oil from two different areas in Tuscany 195
1,2,3-triazolo[4,5-d]pyridazines - Part VI. New 1-substituted-4-amino derivatives and their affinity towards A(1) and A(2A) adenosine receptors 194
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system 189
Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer 189
Synthesis and antitumor evaluation of 1,8-naphthyridine-2-(1H)-on-3carboxamide derivatives as CB2 selective agonists 188
Application of An Improved HPLC-FL Method to Screen Serine Palmitoyl Transferase Inhibitors 188
A NEW HPLC METHOD FOR THALIDOMIDE DETECTION IN HUMAN PLASMA 187
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity 187
Identification of the first synthetic allosteric modulator of the CB2receptors and evidence of its efficacy for neuropathic pain relief 186
1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor 186
X-Ray analysis, theoretical studies and alfa-adrenergic biopharmacological properties of 1-(2,5-dimethoxyphenyl)-2-aminoethanol and its morpholine analogue. 185
CONFORMATIONALLY RESTRAINED ANALOGS OF SYMPATHOMIMETIC CATECHOLAMINES - SYNTHESIS AND ADRENERGIC ACTIVITY OF TETRAHYDROBENZOCYCLOHEPTENE DERIVATIVES 178
Design, synthesis and preliminary evaluation of (18)F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor 177
Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma 177
Beyond the Direct Activation of Cannabinoid Receptors: New Strategies to Modulate the Endocannabinoid System in CNS-Related Diseases 174
CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides 173
Rational design, synthesis, biological evaluation and labelling of selective cannabinoid CB2 receptor agonists as anticancer agents 170
Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists 170
4-[6-(dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor 170
Anti-proliferative activity of oleocanthal in human malignant cutaneous melanoma cells 167
Design, Synthesis and biological evaluation of new 1,8-naphthyridin-4(1h)-on-3-carboxamide and quinolin-4(1h)-on-3-carboxamide derivatives as CB2 selective agonists 166
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor 165
Conformationally restrained β -blocking oxime ethers: synthesis and β -adrenergic properties of diastereoisomeric anti and syn 2-(5-isoxazolidinyl)ethanolamines 165
Composition of health-promoting phenolic compounds in two extra-virgin olive oils and diversity of associated yeasts 164
Cannabinoid ReceptorActivation Induces Apoptosis through Tumor Necrosis Factor A Mediated Ceramide De novo Synthesis in Colon Cancer Cells, 162
Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase 160
Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: Implications for drug discovery 159
Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system 159
Stereochemistry and dynamics of the hydrobromide of 1-(aminomethyl)-5,6-dihydroxyisochroman, semirigid analogue of catecholamines 155
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands 155
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 155
A2A receptor ligands: Past, present and future trends 153
Conformationally Restrained Analogs of Sympathomimetic Catecholamines. Synthesis, Conformational Analysis, and Adrenergic Activity of Isochroman Derivatives 153
Conformationally restrained analogues of sympathomimetic catecholamines: Synthesis and adrenergic activity of 5,6- and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1(2H)-2′,5′- morpholines] 152
Cannabinoid CB2/CB1 Selectivity. Receptor Modeling and Automated Docking Analysis 152
Immuno-Modulatory Properties of a Quinolin-2-(1H)-on-3-Carboxamide Derivative: Relevance in Multiple Sclerosis 152
Conformationally restrained beta-blocking oxime ethers: synthesis and beta-adrenergic properties of diastereoisomeric anti and syn 2-(5-isoxazolidinyl)ethanolamines 151
The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation 151
SYNTHESIS AND BETA-BLOCKING ACTIVITY OF (R,S)-(E)-OXIMEETHERS OF 2,3-DIHYDRO-1,8-NAPHTHYRIDINE AND 2,3-DIHYDROTHIOPYRANO[2,3-B]PYRIDINE: IDENTIFICATION OF BETA 3-ANTAGONISTS 149
Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology. 149
Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol 149
Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alfa- and beta-adrenergic receptors 148
Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis 147
Determination of water-soluble vitamins in multivitamin dietary supplements and in artichokes by micellar electrokinetic chromatography. 147
Immune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives. 147
Structural optimization of 4-chlorobenzoylpiperidine derivatives for the development of potent, reversible and selective monoacylglycerol lipase (MAGL) inhibitors 147
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold 145
A New 4-phenyl-1,8-naphthyridine Derivative Affects Carcinoma Cell Proliferation by Impairing Cell Cycle Progression and Inducing Apoptosis 145
Role of the benzylic hydroxyl group of adrenergic catecholamines in eliciting a-adrenergic activity. Synthesis and a1- and a2-adrenergic activity of 3-phenyl-3-piperidinols and of their desoxy analogs 145
PHARMACOKINETICS OF INTRAVENOUS AND INTRAMUSCULAR PARECOXIB IN HEALTHY BEAGLES 143
Analgesici oppiodi: HPLC-FL e LC-UV-ESI-MS/MS per la determinazione simultanea del tramadolo e dei suoi metaboliti nel plasma di cavallo 142
Synthesis and evaluation of antihypertensive activity of 1,8-naphthyridine derivatives. Part X 142
Modified RP-LC of Phenylthiocarbamyl Amino Acid Adducts in Plasma Acetonitrile Extracts using Multiple Internal Standards and Photo-Diode UV Detection. 142
Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands 141
A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress 138
Immunomodulatory properties of 1,2-dihydro-4-hydroxy-2-oxo-1,8-naphthyridine-3-carboxamide derivative VL15 137
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors 137
The cannabinoid CB2/CB1 selectivity. Homology modelling and automated docking analysis 136
Structure-based virtual screening: Identification of novel CB2 receptor ligands 134
Role of the benzylic hydroxyl group of adrenergic cattecholamines in eliciting alpha-adrenergic activity. Synthesis and alpha1- and alpha2-adrenergic activity of 3-phenyl-3-piperidinols and of their desoxy analogs 133
ASSESSMENT OF THE PHARMACOKINETIC PROFILE OF TRAMADOL AND ITS MAIN METABOLITES IN PLASMA AND URINE FORM DOGS ORALLY ADMINISTERED WITH CONTRAMAL®, WITH OR WITHOUT FREEZE-DRIED GRAPE-FRUIT JUICE 133
Indoles and Related Compounds as Cannabinoid Ligands, 133
Carbazole-containing arylcarboxamides as BACE1 inhibitors 133
Determination of tramadol and metabolites by HPLC-FL and HPLC-MS/MS in urine of dogs 133
Unusual nitration of substituted 7-amino-1,8-naphthyridine in the synthesis of compounds with antiplatelet activity 132
Synthesis and b-blocking activity of (R,S)-(E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3-b]-pyridine: potential antihypertensive agents. Part IX 132
Spiropiperidine strutturalmente correlate alle catecolamine. Sintesi ed attività recettoriale a- e ß-adrenergica 131
1,8-naphthyridine derivatives potent and selective A1 adenosine antagonists 130
(E)-(ARYLMETHYLENEAMINOXY)ACETAMIDES AS ANALOGS OF NEUROLEPTIC BENZAMIDES - SYNTHESIS AND D-2-DOPAMINERGIC BINDING-AFFINITY 130
Synthesis and antiplatelet activity of some 3-phenyl-1,8-naphthyridine derivatives 130
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists 130
Design, synthesis, and biological evaluation of 1,8-naphthyridin-2(1H)-on-3-carboxamide, quinolin-2(1H)-on-3-carboxamide and 2-oxo-1,2-dihydropyridine-3-carboxamide derivatives as CB2 selective ligands 129
Study on Affinity Profile toward Native and Bovine Adenosine Receptors of a Series of 1,8-Naphthyridine Derivatives 129
Synthesis and biological evaluation of 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists 128
IN VITRO METABOLISM OF TRAMADOL IN HORSES: PRELIMINARY DATA 128
PHARMACOKINETICS OF DIFFERENT FORMULATIONS OF TRAMADOL IN THE HORSE 128
Adenosine receptor modelling. A1/A2a selectivity 127
Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors 127
CONFORMATIONAL EFFECTS ON THE ACTIVITY OF DRUGS .13. A REVISION OF PREVIOUSLY PROPOSED MODELS FOR THE ACTIVATION OF ALPHA-ADRENERGIC AND BETA-ADRENERGIC RECEPTORS 126
Synthetic cannabinoid receptor agonists and antagonists: implication in CNS disorders 126
Synthesis of New 1,2,3-triazolo[1,2-a]benzotriazole derivatives or substituted 2,3-benzo-1,3a,6,6a-tetraazapentalenes. II” 125
18FLUORINE-LABELED NITROGEN HETEROCYCLIC DERIVATIVES AS NEW CANDIDATE FOR CANNABINOID CB2 RECEPTOR PET IMAGING 125
Tyrosol-enriched tomatoes by diffusion across the fruit peel from a chitosan coating: a proposal of functional food 125
Conformationally restrained analogs of sympathomimetic catecholamine. Synthesis and adrenergic activity of tetrahydrobenzocycloheptene derivatives 124
Synthesis of 3- or 4-phenyl-1,8-naphthyridine derivatives and evaluation of antimycobacterial and antimicrobial activity 124
HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF THALIDOMIDE IN PATIENTS AFFECTED BY HEPATOCELLULAR CARCINOMA 124
Confronto fra le affinità verso i recettori adenosinici umani e bovini di ligandi selettivi 1,8-naftiridinici. 123
Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands 123
Totale 18.523
Categoria #
all - tutte 70.717
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 70.717


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.704 131 67 97 104 124 113 127 155 175 158 85 368
2021/20222.425 80 255 52 123 385 300 114 131 96 66 161 662
2022/20233.043 397 418 246 250 348 382 33 216 459 29 142 123
2023/20244.780 305 245 280 165 339 258 152 35 31 2.650 88 232
2024/20256.503 28 235 125 385 605 697 526 391 602 793 785 1.331
2025/2026251 251 0 0 0 0 0 0 0 0 0 0 0
Totale 27.483