MANERA, CLEMENTINA
 Distribuzione geografica
Continente #
NA - Nord America 17.389
EU - Europa 9.202
AS - Asia 7.989
SA - Sud America 1.087
AF - Africa 281
OC - Oceania 18
Continente sconosciuto - Info sul continente non disponibili 6
Totale 35.972
Nazione #
US - Stati Uniti d'America 14.675
IT - Italia 2.727
CA - Canada 2.623
SG - Singapore 2.391
CN - Cina 2.205
FI - Finlandia 2.179
HK - Hong Kong 1.247
SE - Svezia 1.080
BR - Brasile 894
VN - Vietnam 727
DE - Germania 694
BG - Bulgaria 481
FR - Francia 399
TR - Turchia 390
PL - Polonia 368
GB - Regno Unito 305
KR - Corea 257
RU - Federazione Russa 236
UA - Ucraina 217
IN - India 210
AT - Austria 182
JP - Giappone 165
CH - Svizzera 94
BD - Bangladesh 63
CI - Costa d'Avorio 62
AR - Argentina 55
MX - Messico 51
IQ - Iraq 49
NL - Olanda 46
PK - Pakistan 46
NG - Nigeria 44
SA - Arabia Saudita 38
MA - Marocco 37
ES - Italia 36
GR - Grecia 36
BE - Belgio 32
ID - Indonesia 31
IL - Israele 28
EC - Ecuador 26
VE - Venezuela 25
ZA - Sudafrica 24
SN - Senegal 23
CZ - Repubblica Ceca 20
PH - Filippine 20
CO - Colombia 19
PE - Perù 19
EG - Egitto 18
TN - Tunisia 18
AU - Australia 17
IE - Irlanda 16
KE - Kenya 16
PY - Paraguay 16
UZ - Uzbekistan 16
UY - Uruguay 14
IR - Iran 11
NP - Nepal 11
AE - Emirati Arabi Uniti 9
AZ - Azerbaigian 9
CL - Cile 9
DZ - Algeria 9
ET - Etiopia 9
JM - Giamaica 9
JO - Giordania 8
KZ - Kazakistan 7
MY - Malesia 7
RO - Romania 7
RS - Serbia 7
AL - Albania 6
BO - Bolivia 6
CR - Costa Rica 6
EU - Europa 6
GE - Georgia 6
PS - Palestinian Territory 6
BJ - Benin 5
LT - Lituania 5
TT - Trinidad e Tobago 5
BY - Bielorussia 4
HU - Ungheria 4
LB - Libano 4
PA - Panama 4
PT - Portogallo 4
BA - Bosnia-Erzegovina 3
DM - Dominica 3
GA - Gabon 3
GY - Guiana 3
NI - Nicaragua 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
TH - Thailandia 3
ZM - Zambia 3
AM - Armenia 2
AO - Angola 2
BB - Barbados 2
BH - Bahrain 2
BW - Botswana 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
HN - Honduras 2
KG - Kirghizistan 2
LI - Liechtenstein 2
Totale 35.937
Città #
Montreal 2.317
Helsinki 1.964
Woodbridge 1.518
Ashburn 1.386
Singapore 1.382
Ann Arbor 1.287
Hong Kong 1.222
Houston 998
Fairfield 950
Chandler 912
Santa Clara 811
San Jose 808
Dallas 655
Milan 540
Serra 533
Sofia 481
Shanghai 435
Beijing 413
Wilmington 364
Seattle 345
Hefei 337
Cambridge 307
New York 284
Jacksonville 270
Ottawa 246
Dong Ket 243
Seoul 241
Boardman 237
Izmir 235
Princeton 226
Los Angeles 218
Pisa 187
Lawrence 184
Lauterbourg 164
Medford 163
Vienna 154
Nanjing 148
Tokyo 144
Ho Chi Minh City 135
Council Bluffs 129
Munich 117
Des Moines 110
Istanbul 99
Marseille 99
Hanoi 95
Dearborn 86
Florence 84
Bern 82
Rome 80
Buffalo 78
Redondo Beach 77
São Paulo 73
Frankfurt am Main 65
Lucca 62
Abidjan 61
Columbus 60
London 60
San Diego 59
Boulder 54
The Dalles 54
Jüchen 53
Redwood City 49
Nanchang 45
Lagos 44
Turku 42
Orem 40
Warsaw 40
Fuzhou 39
Shenyang 39
Livorno 37
Pune 36
Ogden 35
Kunming 33
Brussels 31
Pistoia 30
Chicago 28
Jiaxing 28
Da Nang 27
Nuremberg 27
Pescara 27
San Francisco 27
Atlanta 26
Falls Church 26
Rio de Janeiro 26
Hangzhou 25
Bremen 24
Casablanca 24
Guangzhou 24
Brooklyn 23
Dakar 23
Düsseldorf 23
Grafing 23
Hyderabad 23
Norwalk 23
Belo Horizonte 22
Genoa 22
Baghdad 21
Brasília 20
Chennai 20
Denver 20
Totale 26.323
Nome #
Synthesis and a- and ß-adrenergic activity of spiromorpholines structurally related to sympathomimetic catecholamines 4.645
Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells 369
4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors 329
1,2,3-Triazolo[1,5-a][1,4]- and 1,2,3-Triazolo[1,5-a][1,5]benzodiazepine derivatives: synthesis and benzodiazepine receptor binding. 323
1,2,3-triazolo [4,5-d] pyridazines-V. Preparation and adenosine receptor binding of new 4-amino derivatives. 311
1,2,3-TRIAZOLO[4,5-e]-1,2,4-TRIAZOLO[3,4-c]PYRIMIDINES 283
1,2,3-Triazolo[4,5-d]-1,2,4-triazolo[4,3-b]pyridazines 264
1,2,3-Triazolo[1,5-a]quinoxalines: synthesis and binding to benzodiazepine and adenosine receptors 261
1,2,3-TRIAZOLO[4,5-D]PYRIDAZINES. PART VI. NEW 1-SUBSTITUTED-4-AMINO DERIVATIVES AND THEIR AFFINITY TOWARDS A1 AND A2 ADENOSINE RECEPTORS 255
Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer 254
1,2,3-triazolo[4,5-d]pyridazines - Part VI. New 1-substituted-4-amino derivatives and their affinity towards A(1) and A(2A) adenosine receptors 250
Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts 246
Application of An Improved HPLC-FL Method to Screen Serine Palmitoyl Transferase Inhibitors 245
X-ray analisis, theoretical studies and a-adrenergic biopharmacological properties of 1-(2,5-dimethoxyphenyl)-2-aminoethanol and its morpholine analogue 238
Diversity of yeast community composition in olive oil from two different areas in Tuscany 238
1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors. 229
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity 228
Beyond the Direct Activation of Cannabinoid Receptors: New Strategies to Modulate the Endocannabinoid System in CNS-Related Diseases 228
A NEW HPLC METHOD FOR THALIDOMIDE DETECTION IN HUMAN PLASMA 222
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system 222
Synthesis and antitumor evaluation of 1,8-naphthyridine-2-(1H)-on-3carboxamide derivatives as CB2 selective agonists 221
Anti-proliferative activity of oleocanthal in human malignant cutaneous melanoma cells 221
X-Ray analysis, theoretical studies and alfa-adrenergic biopharmacological properties of 1-(2,5-dimethoxyphenyl)-2-aminoethanol and its morpholine analogue. 220
Identification of the first synthetic allosteric modulator of the CB2receptors and evidence of its efficacy for neuropathic pain relief 220
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor 216
Structural optimization of 4-chlorobenzoylpiperidine derivatives for the development of potent, reversible and selective monoacylglycerol lipase (MAGL) inhibitors 214
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors 213
Tyrosol-enriched tomatoes by diffusion across the fruit peel from a chitosan coating: a proposal of functional food 212
Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma 208
1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor 208
Rational design, synthesis, biological evaluation and labelling of selective cannabinoid CB2 receptor agonists as anticancer agents 201
Composition of health-promoting phenolic compounds in two extra-virgin olive oils and diversity of associated yeasts 201
Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands 201
Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands 201
CONFORMATIONALLY RESTRAINED ANALOGS OF SYMPATHOMIMETIC CATECHOLAMINES - SYNTHESIS AND ADRENERGIC ACTIVITY OF TETRAHYDROBENZOCYCLOHEPTENE DERIVATIVES 200
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands 200
Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase 199
Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: Implications for drug discovery 199
Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists 196
SYNTHESIS AND BETA-BLOCKING ACTIVITY OF (R,S)-(E)-OXIMEETHERS OF 2,3-DIHYDRO-1,8-NAPHTHYRIDINE AND 2,3-DIHYDROTHIOPYRANO[2,3-B]PYRIDINE: IDENTIFICATION OF BETA 3-ANTAGONISTS 195
The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation 195
Design, synthesis and preliminary evaluation of (18)F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor 194
New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2 193
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 191
4-[6-(dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor 191
Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system 191
Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids 191
CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides 190
Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells 189
Conformationally Restrained Analogs of Sympathomimetic Catecholamines. Synthesis, Conformational Analysis, and Adrenergic Activity of Isochroman Derivatives 188
A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress 185
Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alfa- and beta-adrenergic receptors 184
Conformationally restrained beta-blocking oxime ethers: synthesis and beta-adrenergic properties of diastereoisomeric anti and syn 2-(5-isoxazolidinyl)ethanolamines 181
Synthetic cannabinoid receptor agonists and antagonists: implication in CNS disorders 181
Cannabinoid ReceptorActivation Induces Apoptosis through Tumor Necrosis Factor A Mediated Ceramide De novo Synthesis in Colon Cancer Cells, 180
Role of the benzylic hydroxyl group of adrenergic cattecholamines in eliciting alpha-adrenergic activity. Synthesis and alpha1- and alpha2-adrenergic activity of 3-phenyl-3-piperidinols and of their desoxy analogs 179
Design, Synthesis and biological evaluation of new 1,8-naphthyridin-4(1h)-on-3-carboxamide and quinolin-4(1h)-on-3-carboxamide derivatives as CB2 selective agonists 179
Cannabinoid CB2/CB1 Selectivity. Receptor Modeling and Automated Docking Analysis 179
Stereochemistry and dynamics of the hydrobromide of 1-(aminomethyl)-5,6-dihydroxyisochroman, semirigid analogue of catecholamines 178
Conformationally restrained β -blocking oxime ethers: synthesis and β -adrenergic properties of diastereoisomeric anti and syn 2-(5-isoxazolidinyl)ethanolamines 178
Immunomodulatory properties of 1,2-dihydro-4-hydroxy-2-oxo-1,8-naphthyridine-3-carboxamide derivative VL15 177
Modified RP-LC of Phenylthiocarbamyl Amino Acid Adducts in Plasma Acetonitrile Extracts using Multiple Internal Standards and Photo-Diode UV Detection. 177
Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology. 176
Immuno-Modulatory Properties of a Quinolin-2-(1H)-on-3-Carboxamide Derivative: Relevance in Multiple Sclerosis 176
Conformationally restrained analogues of sympathomimetic catecholamines: Synthesis and adrenergic activity of 5,6- and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1(2H)-2′,5′- morpholines] 174
Spiropiperidine strutturalmente correlate alle catecolamine. Sintesi ed attività recettoriale a- e ß-adrenergica 170
Analgesici oppiodi: HPLC-FL e LC-UV-ESI-MS/MS per la determinazione simultanea del tramadolo e dei suoi metaboliti nel plasma di cavallo 170
Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol 170
A2A receptor ligands: Past, present and future trends 169
Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice 169
Synthesis and evaluation of antihypertensive activity of 1,8-naphthyridine derivatives. Part X 166
Determination of water-soluble vitamins in multivitamin dietary supplements and in artichokes by micellar electrokinetic chromatography. 166
Synthesis and antiplatelet activity of some 3-phenyl-1,8-naphthyridine derivatives 165
Role of the benzylic hydroxyl group of adrenergic catecholamines in eliciting a-adrenergic activity. Synthesis and a1- and a2-adrenergic activity of 3-phenyl-3-piperidinols and of their desoxy analogs 164
Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis 163
PHARMACOKINETICS OF INTRAVENOUS AND INTRAMUSCULAR PARECOXIB IN HEALTHY BEAGLES 162
The cannabinoid CB2/CB1 selectivity. Homology modelling and automated docking analysis 161
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold 161
A New 4-phenyl-1,8-naphthyridine Derivative Affects Carcinoma Cell Proliferation by Impairing Cell Cycle Progression and Inducing Apoptosis 161
Structure-based virtual screening: Identification of novel CB2 receptor ligands 160
Immune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives. 160
ASSESSMENT OF THE PHARMACOKINETIC PROFILE OF TRAMADOL AND ITS MAIN METABOLITES IN PLASMA AND URINE FORM DOGS ORALLY ADMINISTERED WITH CONTRAMAL®, WITH OR WITHOUT FREEZE-DRIED GRAPE-FRUIT JUICE 159
1,8-naphthyridine derivatives potent and selective A1 adenosine antagonists 159
Determination of tramadol and metabolites by HPLC-FL and HPLC-MS/MS in urine of dogs 159
HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF THALIDOMIDE IN PATIENTS AFFECTED BY HEPATOCELLULAR CARCINOMA 158
Synthesis and b-blocking activity of (R,S)-(E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3-b]-pyridine: potential antihypertensive agents. Part IX 158
Study of the virucidal effect on Human Adenovirus type 5 of polysaccharides extracted from Arthrospira platensis and Dunaliella salina 157
Design, synthesis, and biological evaluation of 1,8-naphthyridin-2(1H)-on-3-carboxamide, quinolin-2(1H)-on-3-carboxamide and 2-oxo-1,2-dihydropyridine-3-carboxamide derivatives as CB2 selective ligands 156
Unraveling the Protective Role of Oleocanthal and Its Oxidation Product, Oleocanthalic Acid, against Neuroinflammation 155
(E)-(ARYLMETHYLENEAMINOXY)ACETAMIDES AS ANALOGS OF NEUROLEPTIC BENZAMIDES - SYNTHESIS AND D-2-DOPAMINERGIC BINDING-AFFINITY 155
Conformationally restrained β -blocking oxime ethers. 4. Chiral 2-(3'-(5'-p-chlorophenyl)isoxazolidinyl)ethanolamines as conformationally restrained analogs of methyloxyiminomethyl (MOIM) β -adrenergic antagonists: synthesis, configuration and β -adrenergic properties 153
PHARMACOKINETICS OF DIFFERENT FORMULATIONS OF TRAMADOL IN THE HORSE 153
CB1 receptor binding sites for NAM and PAM: A first approach for studying, new n‑butyl‑diphenylcarboxamides as allosteric modulators 153
Synthesis and biological evaluation of 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists 152
Carbazole-containing arylcarboxamides as BACE1 inhibitors 151
Sintesi e attività recettoriale adrenergica di analoghi tetraidronaftalenici di catecolamine simpatomimetiche 150
Synthesis of New 1,2,3-triazolo[1,2-a]benzotriazole derivatives or substituted 2,3-benzo-1,3a,6,6a-tetraazapentalenes. II” 150
IN VITRO METABOLISM OF TRAMADOL IN HORSES: PRELIMINARY DATA 150
Adenosine receptor modelling. A1/A2a selectivity 150
Indoles and Related Compounds as Cannabinoid Ligands, 150
Totale 23.948
Categoria #
all - tutte 89.788
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 89.788


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021453 0 0 0 0 0 0 0 0 0 0 85 368
2021/20222.425 80 255 52 123 385 300 114 131 96 66 161 662
2022/20233.043 397 418 246 250 348 382 33 216 459 29 142 123
2023/20244.780 305 245 280 165 339 258 152 35 31 2.650 88 232
2024/20256.503 28 235 125 385 605 697 526 391 602 793 785 1.331
2025/20269.265 562 1.008 889 768 656 694 1.161 383 2.301 632 211 0
Totale 36.497