MANERA, CLEMENTINA
 Distribuzione geografica
Continente #
NA - Nord America 12.343
EU - Europa 5.918
AS - Asia 1.869
AF - Africa 122
SA - Sud America 25
OC - Oceania 14
Continente sconosciuto - Info sul continente non disponibili 6
Totale 20.297
Nazione #
US - Stati Uniti d'America 9.779
CA - Canada 2.560
IT - Italia 2.401
SE - Svezia 1.063
CN - Cina 734
DE - Germania 486
BG - Bulgaria 479
PL - Polonia 339
VN - Vietnam 332
SG - Singapore 265
TR - Turchia 264
GB - Regno Unito 203
UA - Ucraina 197
FI - Finlandia 174
AT - Austria 164
FR - Francia 144
IN - India 106
HK - Hong Kong 102
CH - Svizzera 84
RU - Federazione Russa 67
CI - Costa d'Avorio 58
NG - Nigeria 41
GR - Grecia 32
BE - Belgio 27
CZ - Repubblica Ceca 18
JP - Giappone 18
SN - Senegal 18
BR - Brasile 17
AU - Australia 13
IL - Israele 13
KR - Corea 13
ES - Italia 12
IR - Iran 7
EU - Europa 6
NL - Olanda 6
RO - Romania 6
ID - Indonesia 5
RS - Serbia 5
DM - Dominica 3
IE - Irlanda 3
PK - Pakistan 3
UY - Uruguay 3
DK - Danimarca 2
DZ - Algeria 2
EG - Egitto 2
HU - Ungheria 2
SK - Slovacchia (Repubblica Slovacca) 2
AR - Argentina 1
AZ - Azerbaigian 1
BD - Bangladesh 1
BN - Brunei Darussalam 1
CL - Cile 1
CO - Colombia 1
EC - Ecuador 1
JO - Giordania 1
KZ - Kazakistan 1
LI - Liechtenstein 1
MX - Messico 1
NZ - Nuova Zelanda 1
PE - Perù 1
PT - Portogallo 1
SA - Arabia Saudita 1
TH - Thailandia 1
TN - Tunisia 1
Totale 20.297
Città #
Montreal 2.295
Woodbridge 1.518
Ann Arbor 1.287
Houston 980
Fairfield 950
Chandler 912
Serra 531
Milan 519
Sofia 479
Ashburn 439
Wilmington 363
Seattle 338
Cambridge 307
Beijing 291
Jacksonville 267
Dong Ket 243
Ottawa 242
Izmir 234
New York 232
Princeton 226
Lawrence 184
Medford 163
Pisa 151
Nanjing 147
Vienna 143
Des Moines 109
Hong Kong 100
Marseille 99
Singapore 95
Dearborn 86
Bern 82
Florence 66
Rome 65
Abidjan 58
San Diego 57
Boulder 54
Jüchen 53
Redwood City 49
Nanchang 45
Lagos 41
London 37
Shenyang 36
Ogden 35
Los Angeles 31
Pune 31
Pistoia 30
Kunming 29
Boardman 28
Brussels 27
Jiaxing 27
Pescara 27
Falls Church 26
Frankfurt am Main 26
Bremen 24
Grafing 23
Norwalk 23
Livorno 21
Hyderabad 20
Lucca 20
Pessac 20
Auburn Hills 19
Hebei 19
Dakar 18
Genoa 17
Kocaeli 17
Changsha 16
Warsaw 16
Hefei 15
Orange 15
Tianjin 15
Guangzhou 14
Rimini 14
San Francisco 13
Genova 12
Hangzhou 12
Nürnberg 12
Carrara 11
Helsinki 11
Phoenix 11
San Giuliano Terme 11
Brno 10
Grosseto 10
Zola Predosa 10
North York 9
Cerveteri 8
Dallas 8
Indiana 8
Lappeenranta 8
Talence 8
Washington 8
Alessandria 7
Bat Yam 7
Cascina 7
Chengdu 7
Mumbai 7
Perugia 7
São Paulo 7
Bochum 6
Favria 6
New Delhi 6
Totale 15.483
Nome #
Synthesis and a- and ß-adrenergic activity of spiromorpholines structurally related to sympathomimetic catecholamines 2.699
Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells 258
4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors 227
1,2,3-triazolo [4,5-d] pyridazines-V. Preparation and adenosine receptor binding of new 4-amino derivatives. 217
1,2,3-Triazolo[1,5-a][1,4]- and 1,2,3-Triazolo[1,5-a][1,5]benzodiazepine derivatives: synthesis and benzodiazepine receptor binding. 202
1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors. 183
1,2,3-Triazolo[1,5-a]quinoxalines: synthesis and binding to benzodiazepine and adenosine receptors 174
1,2,3-Triazolo[4,5-d]-1,2,4-triazolo[4,3-b]pyridazines 174
1,2,3-TRIAZOLO[4,5-e]-1,2,4-TRIAZOLO[3,4-c]PYRIMIDINES 172
Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts 167
A NEW HPLC METHOD FOR THALIDOMIDE DETECTION IN HUMAN PLASMA 158
1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor 158
1,2,3-triazolo[4,5-d]pyridazines - Part VI. New 1-substituted-4-amino derivatives and their affinity towards A(1) and A(2A) adenosine receptors 156
Diversity of yeast community composition in olive oil from two different areas in Tuscany 155
Design, synthesis and preliminary evaluation of (18)F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor 154
Application of An Improved HPLC-FL Method to Screen Serine Palmitoyl Transferase Inhibitors 154
Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer 154
Synthesis and antitumor evaluation of 1,8-naphthyridine-2-(1H)-on-3carboxamide derivatives as CB2 selective agonists 152
Identification of the first synthetic allosteric modulator of the CB2receptors and evidence of its efficacy for neuropathic pain relief 150
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system 148
1,2,3-TRIAZOLO[4,5-D]PYRIDAZINES. PART VI. NEW 1-SUBSTITUTED-4-AMINO DERIVATIVES AND THEIR AFFINITY TOWARDS A1 AND A2 ADENOSINE RECEPTORS 144
Anti-proliferative activity of oleocanthal in human malignant cutaneous melanoma cells 143
4-[6-(dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor 141
Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma 140
X-Ray analysis, theoretical studies and alfa-adrenergic biopharmacological properties of 1-(2,5-dimethoxyphenyl)-2-aminoethanol and its morpholine analogue. 139
Design, Synthesis and biological evaluation of new 1,8-naphthyridin-4(1h)-on-3-carboxamide and quinolin-4(1h)-on-3-carboxamide derivatives as CB2 selective agonists 138
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity 138
Conformationally restrained β -blocking oxime ethers: synthesis and β -adrenergic properties of diastereoisomeric anti and syn 2-(5-isoxazolidinyl)ethanolamines 136
Cannabinoid ReceptorActivation Induces Apoptosis through Tumor Necrosis Factor A Mediated Ceramide De novo Synthesis in Colon Cancer Cells, 135
Beyond the Direct Activation of Cannabinoid Receptors: New Strategies to Modulate the Endocannabinoid System in CNS-Related Diseases 135
Rational design, synthesis, biological evaluation and labelling of selective cannabinoid CB2 receptor agonists as anticancer agents 133
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor 133
Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists 132
Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase 131
Immuno-Modulatory Properties of a Quinolin-2-(1H)-on-3-Carboxamide Derivative: Relevance in Multiple Sclerosis 129
CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides 128
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands 127
Stereochemistry and dynamics of the hydrobromide of 1-(aminomethyl)-5,6-dihydroxyisochroman, semirigid analogue of catecholamines 126
Cannabinoid CB2/CB1 Selectivity. Receptor Modeling and Automated Docking Analysis 125
Composition of health-promoting phenolic compounds in two extra-virgin olive oils and diversity of associated yeasts 125
SYNTHESIS AND BETA-BLOCKING ACTIVITY OF (R,S)-(E)-OXIMEETHERS OF 2,3-DIHYDRO-1,8-NAPHTHYRIDINE AND 2,3-DIHYDROTHIOPYRANO[2,3-B]PYRIDINE: IDENTIFICATION OF BETA 3-ANTAGONISTS 123
X-ray analisis, theoretical studies and a-adrenergic biopharmacological properties of 1-(2,5-dimethoxyphenyl)-2-aminoethanol and its morpholine analogue 121
Conformationally restrained analogues of sympathomimetic catecholamines: Synthesis and adrenergic activity of 5,6- and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1(2H)-2′,5′- morpholines] 119
PHARMACOKINETICS OF INTRAVENOUS AND INTRAMUSCULAR PARECOXIB IN HEALTHY BEAGLES 119
A2A receptor ligands: Past, present and future trends 119
Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol 119
Determination of water-soluble vitamins in multivitamin dietary supplements and in artichokes by micellar electrokinetic chromatography. 119
Conformationally Restrained Analogs of Sympathomimetic Catecholamines. Synthesis, Conformational Analysis, and Adrenergic Activity of Isochroman Derivatives 119
CONFORMATIONALLY RESTRAINED ANALOGS OF SYMPATHOMIMETIC CATECHOLAMINES - SYNTHESIS AND ADRENERGIC ACTIVITY OF TETRAHYDROBENZOCYCLOHEPTENE DERIVATIVES 118
A New 4-phenyl-1,8-naphthyridine Derivative Affects Carcinoma Cell Proliferation by Impairing Cell Cycle Progression and Inducing Apoptosis 118
The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation 118
Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis 117
Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alfa- and beta-adrenergic receptors 116
Role of the benzylic hydroxyl group of adrenergic catecholamines in eliciting a-adrenergic activity. Synthesis and a1- and a2-adrenergic activity of 3-phenyl-3-piperidinols and of their desoxy analogs 116
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold 115
Immunomodulatory properties of 1,2-dihydro-4-hydroxy-2-oxo-1,8-naphthyridine-3-carboxamide derivative VL15 115
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors 115
Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology. 113
Immune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives. 113
Modified RP-LC of Phenylthiocarbamyl Amino Acid Adducts in Plasma Acetonitrile Extracts using Multiple Internal Standards and Photo-Diode UV Detection. 107
Design, synthesis, and biological evaluation of 1,8-naphthyridin-2(1H)-on-3-carboxamide, quinolin-2(1H)-on-3-carboxamide and 2-oxo-1,2-dihydropyridine-3-carboxamide derivatives as CB2 selective ligands 106
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors 106
Determination of tramadol and metabolites by HPLC-FL and HPLC-MS/MS in urine of dogs 106
Structural optimization of 4-chlorobenzoylpiperidine derivatives for the development of potent, reversible and selective monoacylglycerol lipase (MAGL) inhibitors 105
Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: Implications for drug discovery 105
Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands 105
Conformationally restrained beta-blocking oxime ethers: synthesis and beta-adrenergic properties of diastereoisomeric anti and syn 2-(5-isoxazolidinyl)ethanolamines 104
ASSESSMENT OF THE PHARMACOKINETIC PROFILE OF TRAMADOL AND ITS MAIN METABOLITES IN PLASMA AND URINE FORM DOGS ORALLY ADMINISTERED WITH CONTRAMAL®, WITH OR WITHOUT FREEZE-DRIED GRAPE-FRUIT JUICE 104
Unusual nitration of substituted 7-amino-1,8-naphthyridine in the synthesis of compounds with antiplatelet activity 104
Indoles and Related Compounds as Cannabinoid Ligands, 104
PHARMACOKINETICS OF DIFFERENT FORMULATIONS OF TRAMADOL IN THE HORSE 102
1,8-naphthyridine derivatives potent and selective A1 adenosine antagonists 102
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists 102
Synthesis and biological evaluation of 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists 101
IN VITRO METABOLISM OF TRAMADOL IN HORSES: PRELIMINARY DATA 101
Carbazole-containing arylcarboxamides as BACE1 inhibitors 101
Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system 101
Synthesis of New 1,2,3-triazolo[1,2-a]benzotriazole derivatives or substituted 2,3-benzo-1,3a,6,6a-tetraazapentalenes. II” 100
Synthesis and b-blocking activity of (R,S)-(E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3-b]-pyridine: potential antihypertensive agents. Part IX 100
A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress 100
The cannabinoid CB2/CB1 selectivity. Homology modelling and automated docking analysis 99
Synthesis and evaluation of antihypertensive activity of 1,8-naphthyridine derivatives. Part X 99
Structure-based virtual screening: Identification of novel CB2 receptor ligands 99
Adenosine receptor modelling. A1/A2a selectivity 98
Synthesis and antiplatelet activity of some 3-phenyl-1,8-naphthyridine derivatives 98
Design, synthesis, and biological evaluation of new heterocyclic azotate derivatives as CB2 selective agonists 97
Conformationally restrained analogs of sympathomimetic catecholamine. Synthesis and adrenergic activity of tetrahydrobenzocycloheptene derivatives 96
Synthesis of 3- or 4-phenyl-1,8-naphthyridine derivatives and evaluation of antimycobacterial and antimicrobial activity 96
Analgesici oppiodi: HPLC-FL e LC-UV-ESI-MS/MS per la determinazione simultanea del tramadolo e dei suoi metaboliti nel plasma di cavallo 95
Spiropiperidine strutturalmente correlate alle catecolamine. Sintesi ed attività recettoriale a- e ß-adrenergica 94
HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF THALIDOMIDE IN PATIENTS AFFECTED BY HEPATOCELLULAR CARCINOMA 94
Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors 94
Role of the benzylic hydroxyl group of adrenergic cattecholamines in eliciting alpha-adrenergic activity. Synthesis and alpha1- and alpha2-adrenergic activity of 3-phenyl-3-piperidinols and of their desoxy analogs 93
18FLUORINE-LABELED NITROGEN HETEROCYCLIC DERIVATIVES AS NEW CANDIDATE FOR CANNABINOID CB2 RECEPTOR PET IMAGING 93
SUBSTITUTED 1,2,3-TRIAZOLO[1,5-A]QUINAZOLINES: SYNTHESIS AND BINDING TO BENZODIAZEPINE AND ADENOSINE RECEPTORS 93
Rational Design, Synthesis, and Pharmacological Properties of New 1,8-Naphthyridin-2(1H)-on-3-Carboxamide Derivatives as Highly Selective Cannabinoid-2 Receptor Agonists 93
(E)-(ARYLMETHYLENEAMINOXY)ACETAMIDES AS ANALOGS OF NEUROLEPTIC BENZAMIDES - SYNTHESIS AND D-2-DOPAMINERGIC BINDING-AFFINITY 92
Study on Affinity Profile toward Native and Bovine Adenosine Receptors of a Series of 1,8-Naphthyridine Derivatives 92
Conformationally restrained β -blocking oxime ethers. 4. Chiral 2-(3'-(5'-p-chlorophenyl)isoxazolidinyl)ethanolamines as conformationally restrained analogs of methyloxyiminomethyl (MOIM) β -adrenergic antagonists: synthesis, configuration and β -adrenergic properties 90
Confronto fra le affinità verso i recettori adenosinici umani e bovini di ligandi selettivi 1,8-naftiridinici. 90
Totale 14.983
Categoria #
all - tutte 48.552
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 48.552


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.753 317 196 260 156 226 324 304 192 238 172 276 92
2020/20211.704 131 67 97 104 124 113 127 155 175 158 85 368
2021/20222.425 80 255 52 123 385 300 114 131 96 66 161 662
2022/20233.043 397 418 246 250 348 382 33 216 459 29 142 123
2023/20244.780 305 245 280 165 339 258 152 35 31 2.650 88 232
2024/202521 21 0 0 0 0 0 0 0 0 0 0 0
Totale 20.750